Ladies in their 30s
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hi
a small question. how many of you have got your brca1 brca2 reports.
the doc said since i got breast cancer while in my 30s, this testing makes sense.
i got this funny "unknown" variance in brca2...it seems if not brca1 or brca2, then something else...but cancer under 40, is typically due to a mutation acquired from birth.
pls share your experiance and opinion
thanks.
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BanR - I will have the test in January. How long did it take you to get your report?
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Jianchi..it took 4 weeks
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My BRCA was negative so there was no questions. My test also took 4 weeks. With an unknown variance, do they recommend a follow up or a different gene mutation test? I would ask either my surgeon or MO.
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BanR - I have BRCA1 deleterious mutation (a very common one). Did you speak with the genetic counselor afterwards? My understanding is that with an "unknown" variant they do not know yet if it raises your risk on BC. Somebody else on the BRCA board said that they had a rare mutation and the company offered to test her family for free. You could check back in a year or two with the genetic counselor to see if they know more about your mutation then.
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yes inks..did consult him. its just that no action to be taken till it is proven
what i understand veronica and inks is ..we who have developed cancer at such an early age, have definitely got this mutation from birth.
if not brca1 then brca2..if not brca1and 2 then something else, which has not yet been discovered...but we have definitely got one round of mutation before our birth...we were just born with it, else in no circumstances can so many mutations followed by cancer happen so young.
sporadic cancers happen due to somatic mutations and lead to cancers post 50, but we unfortunately are part of inherited mutations, be in in our family or not..after all somebody in the family has to be a first. ..Sad..feel helpless actually.
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BanR, you should check with your genetic conselor. My BRAC1 & 2 was negative, so i have no BC family history . Sounds like I am one of the unlucky one to have this BC at my age.
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I'm in a young survivors group (under 40) and out of six of us, four were positive for the BRCA mutation and the other two of us had significant family history but tested BRCA negative. Two other women with BC under 40 I met at the cancer center both had significant family history as well. One had a sister who died of BC a few years earlier, also under 40. Of course, this is only anecdotal but it does seem that in many cases there is some kind of genetic component going on. I was told by the genetic counselor that only about 75% of the genetic mutations have been discovered and it was likely that I carried an unknown mutation, as both my grandmother and I had breast cancer in our 30's. My oncologist agreed that I had likely had a predisposition for BC that had been passed down the family line but there is no way to know at this time if it is related to a specific mutation or not. Here is something that kind of explains the differences: http://cancergenetics.wordpress.com/2007/08/01/characteristics-of-hereditary-familial-and-sporadic-cancer-syndromes/
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Thank you for the link. I tested negative for BRCA 1 and 2 and was told I probably had a genetic cancer, but not one that is on the known list. My Ki-67% was high too, so goodie. I had conflicting results on the oncotype and mammaprint for chemo, hence me doing chemo now. I"m also reading that women under 40 that do rads can develop a secondary cancer, so now I'm trying to get out of the 7 weeks of radiation. I'm looking at a partial breast radiation.
Maternal side:
Mother, 33, breast cancer, gave her 3 months to live lived for 20 years died of heart attack.
Grandmother, 58, breast cancer stage IIIB still living has lymphedema her left arm looks like a elephants leg.
1st cousin, 60 breast cancer spread to lungs died
1st cousin, 60 breast cancer died
1st cousin, 58, prostrate cancer died
Great Uncle, 60, lung cancer died
Paternal side:
Uncle, 58, prostate cancer
Grandfather, 60 skin cancer, died
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hi ladies
i developed bc at 34. Mum to a 4 year old (turning 4 xmas day)
I developed BC from hodgkins disease i developed when I was 18 radiation caused bc!
My onc told me many young ladies develop bc due to the contraception pill also.
So many factors. Heard vit d also plays a factor.
arent we just lucky!!
Merry Xmas all. Off for our xmas eve dinner than church.
Here is to a healthy 2014 ahead:) x
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checked with counsellor Soriya . Going by what Gildedcage wrote ....a lot of genes and mutations have not been studied. So our mutations come under them..I clearly have one in my brac2, it's called g1711443A>C, this is an unknown mutation,if someone has this too then may be it's related to breast cancer
Thanks for the link Gildedcage ..
Fairdogmother.you do have strong familial history of cancer. If brac is negative then maybe tp53 gene could have a harmful mutation in your case.
Trail, even I heard radiation causes Bc and lung cancer. Sorry to hear that you got one because of it. In fact the chemo drug cyclophosphamide I am taking might cause acute myeloid leukemia to me later.. Small chance. But then the fact we got cancer in our 30s was also a small chance
Lots of love to all... Have fun on Christmas Eve!
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traii - happy birthday to your lo. My oldest turns 8 today.
Since we're talking about it, I'm BRCA 1&2 negative and have no family history. I blame 9 years of birth control pills. Those are nasty little things.
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McKatherine: Just 9 years did so much damage!!! I am yet to figure out what could be my cause..as of now that variant of uncertain significance in my brca2 gene is freaking me out. If only i could take my case somehow to Myriad or to any higher lab. Will have to talk to my hospitals lab about it. A very distant relative of mine, got dx with ovarian cancer at 30. I tried to convince her to get her brca1 and 2 done...just in case we both share the same variant then maybe some conclusion can be drawn..but people generally are not too keen when it comes to knowing future risks.
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I too wonder what could have caused me to be diagnosed at 37, as I really don't have much family history to speak of - just one grandma. I have questioned my use of birth control pills, I have questions my eating and exercising habits. I have questioned everything. Truth is - that doesn't do me any good and get me anywhere - expect to cause me to worry about all my future choices. We got it. It stinks. But we did. Can't go back and change it or undo any of our past behaviors. Trying to contribute to genetics research in the hopes of one day eradicating this awful disease is one thing. But spinning your wheels and stressing yourself to figure out how you personally got cancer seems like a not so mentally healthy idea. Give yourselves a break. We all got dealt a monumentally crappy hand. How we deal with it now and moving forward is what defines us. Sorry if I'm being too harsh, but I've been watching this current line of conversation continue on and felt like I needed to express my two cents... Wishing you all a happy and healthy holiday season and a fresh new year ahead of us!
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ramols-Love the attitude.
I knew my cancer was coming. I started to lose weight and get into shape for my battle. I just hoped it would come when I was a little older not at 36. I hope there can be more genetic testing for those with a family history. I also read that not having children is a factor for BC. We don't have kids. Who knows? All I know now is the only thing I can control is what I wear and my attitude on this journey.
Merry Christmas to all.
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what about ivf ? . I am braca negative and got this after 2 attempts ?
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FairyDog, what do you mean not having kids is a factor? You mean it increases your risk of bc? Because it seems to me that a lot of young women (at least on this board) do have kids?
I have no family history and no gene mutations. I do however have 14 years of birth control at 29. (My periods were awful so my mom had her obgyn put me on them so I wouldn't be miserable for days every month). Plus I was awful about remembering to take them!
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having kids after 30 or not having any is both a risk factor known for breast cancer.
S
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Hello 30 somethings!! Thanks for being here because under 40 is a rarity compared to all bc diagnosed each year....I read somewhere out of 198,000 bc diagnosed yearly only 4% are under 40. I feel so special....not! Thank you God for thinking I could carry this with 3 young children, 4 including the hubs, and a new nonprofit. Besides the feeling of failing my jobs for the next year, twp, three, whatever...I'm great:))
Anyways, sorry you are all in this similiar boat...I couldn't understand the hoopla about the walks but since this bitch came along, I get it....totally effin get it, lol!
Steph
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Steph, question, how did your surgery go? I did neoadjuvant (sp?) chemo so I don't have surgery until February and I don't get to see my PS until the 9th.
My last day of chemo will be your first. I didn't have Adriamycin though so I don't think we will have similar experiences? I heard that's harder?
Are you heading the non-profit? What does your non-profit do?
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Hello! Ladies! I am new here. I am 33 yrs old and TNBC. I just done with my lumpectomy on Dec 16th. I am going to Chemo from Jan 9th!
I hope you all will have A Happy New Year! I really need to have better year!!!! 2013 wasn't the good year for me....
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candy,
We live pretty close to each other. I am 34 TNBC, diagnosed in October.
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candycandy- I'm sorry you've had such a hard year. I hope 2014 is a better year for you and all of us. I know how heart breaking it is to be planning for treatment when you had hopes of planning for a baby. We had just starting trying for our second when I found the lump...I'm glad I didn't get pregnant right away cause I think it would be a lot harder worrying about harming a fetus while trying to fight cancer. My chemo treatments are slated to start in late January so I'll probably catch up with you on the Jan chemo thread...
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welcome candy- I hope 2014 is a better year also, 2013 has been very stressful to say the least! I go for my third chemo this Friday and am already dreading it. I will be glad when I'm finished so life can return to normal or at least a new normal! Here's to a happy and healthy new year!
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sunshower- I noticed you live close to me, we probably share some of the same docs. I am 2 mo ahead of you, let me know if I can help in any way.
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Veronica37...thank you! Maybe we could even get together sometime. It helps to have support from other young women who are going through the same things.
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sunshower- that would be nice sometime! While at chemo, I ran into a girl I used to work with going through the same thing. Its amazing how many of us in our 30's are going through this. Let me know if you have any questions that I may be able to help. You can private message me also.
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Hey there, my surgery was a success?! Lol, it was fine when I first came out cuz they numb you in the tissue along with morphine, dilated, all of it...its been a long recovery for me and im blaming all 3 of my little ones completely. Ha! I do too much...just hit 3.5 wks out still have nerve pain in my arm and armpit...and then there's my old friend the drain. Most women have their drains out in two weeks but this lil guy is like an orphaned child. Instead of tantrums he hooks onto cabinet handles and gives me a good yank as I work the kitchen during dinner.
Lots and lots and lots of icing....had a couple nights I woke up with pain and hubby ran for ice and meds immediately then I was fine. I only had mastectomy but happy to just take one off at a time with so many lil kids home for the holidays. Oh, and the worst day was my anesthesia headache 4 days out...wow! Hit me with an iron pan, so bottom line, it hurts so have tons of help. If you dont have family use friends...if I had it to do over I may have stayed at a friends house with no kids. However, you will get through it fine, one day at a time girl! Xo. Ste
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Oh, our nonprofit provides a brilliant emotional wellness class to middle and high school kids in schools. We are in the middle of our second research and pilot programs...serving almost 300 students this year. The #13 gifted program in the nation just trained with us during November...
Its my 4th baby...I came from a very tough childhood, horrible divorce, and was just so broken. I did so much therapy, antidepressants, self medicated, etc but until I started using the techniques taught in this curriculum I was still pretty broken. No longer though! I feel blessed every day and I have mastered many of the concepts, however not perfect and always a work in progress:)
Steph
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I have learned that there is no planning allowed during this battle! Chemo delayed Friday due to high liver enzymes from taxotere. This happened in round 2 also. I am such a planner and trying to work and deal with sports with the kids, this sucks! Oh well guess I need my liver, I have plans for it when chemo is done,lol!
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