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March 2011 chemo-lounge

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Comments

  • Stilts
    Stilts Member Posts: 228

    Colodisney: glad the acupuncture is working for you...maybe I should give it another try on my poor feet !!! What kind of procedure do they use ???...when I went previously, they used a machine that gave small electrical "shocks'. I am currently working with a trainer who has special training for cancer patients and lymphedema prevention. She has me using light weights for bicep curls etc. and then I am supposed to advance to heavier weights slowly...we'll see how it goes !!!...apparently the studies out there show significant decrease in lymphedema with the weight program she teaches.

    Getting ready for the Relay for Life again this year in Burnsville, MN....hope to be able to stay up all night for it...last year I was still getting chemo and didn't last too long !!! What a difference a year makes !!! Just enjoying NOT thinking about BC every day...it is what it is..

    Happy Summer to all...

  • Colodisneylover
    Colodisneylover Member Posts: 183

    Stilts-Yes, I am getting the same kind of treatment you described. They put in the needles (lots of them) and then hook them up and I get shocked. Nothing that hurts, just a pulsating sensation. 

  • Jules59
    Jules59 Member Posts: 148

    Just checking in with you all.  It's been a while.

    I am currently doing physical therapy for frozen shoulders (both of them) 3 times a week.  It became impossible for me to get on my horse by myself, so my oncologist insisted I see a PT or an orthopedic surgeon, so guess which one I chose?  I have heard people speak about frozen shoulders, but I had no idea it was such a painful condition. Therapy is working, I have been able to mount my mare this week, but I still have a way to go before I'm back to normal.

    Mammogram and ultrasound on July 2.  I was supposed to see my BS immediately following, but cancelled my appointment after much argument with my BS's scheduler.  I just felt he had nothing to offer me at this point, and a manual breast exam would be redundant.

    Penny, have a wonderful time on your trip.  Be sure to post a picture when you get back.

  • PennyCookson
    PennyCookson Member Posts: 356

    Hi Jules - glad shoulder the therapy is working - much better option than surgery, hope it keeps getting better. 

  • Huskerkkc
    Huskerkkc Member Posts: 471

    Hi gals,

    I took a lonnnng break from the boards (7 wks?) but am back. Guess where I checked first? The Lounge, of course!

    It was kind of stressful at the end of to my school year and I was struggling to stay focused and found myself getting anxious after reading some of the other boards (never is one). I guess I got freaked out a little bit, plus had 3-month appts starting up again, which caused some major anxiety this time. Anyway, all is well and I'm on summer break until August!

    Currently I am in Minneapolis for a national conference for school counselors- came by myself just to get away. Nine hour drive from home but am enjoying the conference and have some colleagues from other towns that are here, so not completely alone!

    Lounge buddy Sue saw via FB that I was here and we are going to meet Monday for lunch! Although I've "met" lots on these boards this will be my first face-to-face, so am excited for that! Hopefully one of us will remember to take a picture so we can share with y'all!

  • Colodisneylover
    Colodisneylover Member Posts: 183

    Kristy-Glad to see you back here!  Have fun meeting up with Sue!  Sounds fun.

    Jules-Your shoulder pain sounds very painful.  I hope it improves soon!

    I read an article earlier this week about a woman in Seattle who had a double mastectomy who wanted to go topless at the local pool.  It became a big news story.  It really got me thinking how I view my body, my foobs, and my self image.  Anyone else see it? What did you think?

  • Kay_G
    Kay_G Member Posts: 1,914

    Hi all! Glad to hear from so many, and hear how well you are all doing. I finished my year of herceptin last week and get my port out on Wednesday. In early August I get my nipple reconstruction, then tattoos. Still having heart issues from herceptin, on two different meds for it. Hoping now that I am finished, my heart will get back to normal and hopefully will be able to get off the meds.



    I saw that woman in the pool. I am not quite sure what I think, I think she should wear a woman's bathing suit, but she says that is painful for her. She should be able to swim in the pool without pain. I just don't know which way to go on it.

  • ksmatthews
    ksmatthews Member Posts: 743

    I heard that on the radio too and I too am not sure what my opinion of it is....complicated situation.

    Jules so glad you checked in.  I hope they get your shoulder issues taken care of.

    I go July 17th for bone scan and ct scan.  Praying for all clear again.  If so they may not make me do anymore.  Fingers Crossed!!! 

  • fluffqueen01
    fluffqueen01 Member Posts: 1,801

    Hi all! Miss you.



    Mdg...Lance Armstrong has some kind of program in a partnership with the Y, that is a fitness class for cancer survivors, and it is free. There is info on his website. Might be something to check into.



    Penny...my PS told me he and his wife were taking a vacation away from the kids. I said ooh, what kind of romantic thing doyou have planned? Answer? Hiking down into and back out of the grand canyon, in June. I just looked at him with horror. Hot...desert...all I can think of is I would be one continual hot flash.



    Kay...congrats! I finished in March, had fat grafting, nips, and deporting ten days later, And just finished my tats. They are looking good! Might do one more fat grafting shot later in the year.



    KSMathews....jealous about your tests. My doc doesn't believe in them. I have worn on him though, so I am calling my insurance company tomorrow and if they tell me it is covered, then, I think He will order them....just to shut me up.



    Really, if we get mammos to find BC early, then why would we just wait around for a symptom after that? We need those baseline tests for,peace of mind.



    On the topless front....is that a public pool? If so, wear a shirt. She could wear a tshirt and be fine. You cant convince me that every swimming suit causes pain.



    With that being said though, somebody on one of the threads a couple months ago was in New Orleans, and stopped in the police station to see if the could be arrested for flashing if the didnt have real boobs. I laughed myself silly. Would have loved to see the look on the police officer's face.

  • ksmatthews
    ksmatthews Member Posts: 743

    fluff they have been doing my test every 6 months though let me go 9 months for this one, and this is first bone scan since I was first dx.  When dx they saw a small spot on liver and small spot on lung, but all my dr's are sure it is nothing.  So far no changes at all, so they said they will check this time and if all is still the same, they probably wont check anymore.

    I am praying this is the case.

    on the topless front I too think a tshirt or tank top would be fine.  I am too worried about how the kids reaction would be to the scars and appearance.   

  • Huskerkkc
    Huskerkkc Member Posts: 471

    Hi gals,

    Have been in Minneapolis for five days for national school counselor conference. Stilts (Sue) saw my updates on Facebook and invited me to lunch. We talked for two hours! Lots of fun. Wish we could all get together some time. I imagine we'd laugh and talk for hours and hours! I'm on the left, Sue on the right. We have similar hair-short, curly, and blonde!

  • divinemrsm
    divinemrsm Member Posts: 6,611

    Cool

    Huskerkkc, absolutely love the photo of you & Stilts!  You'd never know the adversity the two of you went through just a year or so ago.  How nice you got together. Thanks for posting! 

  • Colodisneylover
    Colodisneylover Member Posts: 183

    Stilts and Huskerkkc-You both look GREAT! :)  So glad you got to get together.

  • maxineo
    maxineo Member Posts: 199

    Hi all- Just checking in...I read posts more than I write them!

    Sue- you and I have the same hairstyle except yours is blonder! Now how did that happen? Wink  Really, you two look wonderful! What a great time you must have had.  I am doing Relay for Life again this year. It was the day after my last chemo treatment last year...indeed, what a difference a year makes.

    penny- I love that you are continuing to travel the world.  I hope to do more of that when the kids are grown but am doing what I can in the meantime.

    kay- Congrats on finishing the herceptin! What a long journey this has been for you.

    mdg - I applaud you for your energy! I have been pretty good about exercising, but it has NOT been as energetic as I would like. I just can't muster the stamina, and my knees and ankles are HATING tamoxifen.

    jules and ksmatthews - Good luck on upcoming scans. I have a breast MRI in early July (half-price). Not looking forward to it either!

    fluff - love the story about New Orleans! My take on it is that she probably could wear something and be comfortable, but I think it's good that she push the issue.  Hats off to her bravery.

    I have been doing pretty well.  BC is always in my thoughts, but it isn't nearly as pervasive. I am HATING hot flashes with a passion. I thought I was tolerating tamoxifen and zoladex pretty well, but I'm not. Joint pain, irritable, and wretched hot flashes.  I was in San Francisco for a few days and I LOVED it because cool weather really limited the flashes.  Any hope that they will EVER go away??  My MO says I will be on hormonals and ovarian suppression for at least 10 years...10 hot years (and not in a good way).

  • mdg
    mdg Member Posts: 1,468

    The effexor has helped my hot flashes quite a bit...fyi.



    Husker and stilts....I see two beautiful and healthy women. There is NO trace of what you have been through. I wish we could all meet up sometime.

  • Silia
    Silia Member Posts: 265

    Gorgeous photo of the two of you, Husker and Stilts.  It's awesome that you two got together.  I've so enjoyed meeting up with Kay a couple of times!  I'm so frustrated by my hot flashes.  Carry a fold up fan in my purse at all times (frequently have to use when in front of a roomful of people - ugh...)  Bought nightgowns that are supposed to wick the moisture away.  They don't work.  Good news is that I was in a foul, down mood yesterday but went to my acupuncturist and am much better today.  Thanks goodness.  Wish me well with my flap surgery on Friday.  I just keep saying "a week from today, I'll be" and fill in the blank with "out of surgery" or "out of ICU" or "home from the hospital" etc.  At this point I'm sorry I didn't do this surgery at the front end and I'd be well over it by now (hindsight, ya know?!)  BTW, my top hair and eyebrows are still quite thin.  I have to use a toupee on top which thankfully blends well.  Final comment - Divine, your kitten is adorable!!  Sending hugs all around.  Putting Katy Perry's Fireworks on the jukebox.  Happy summer and safe travels to all.  (Penny, compared to you, I feel like a complete couch potato!!!)

  • PennyCookson
    PennyCookson Member Posts: 356

    Great picture - you both look so well.

    Good luck Friday Silia 

    Lovely to hear from everyone - ehugs to you all

  • ksmatthews
    ksmatthews Member Posts: 743

    Love the picture!  Both you ladies look great!

    Sillia will be thinking of you on Friday.  Good luck!!! 

  • Silia
    Silia Member Posts: 265

    Thanks for all the good wishes!  Here's my dilemma du jour:  I'm self-employed and just got a call about a possible project which would have me presenting/facilitating at an all-day meeting on August 1 (4 1/2 weeks post surgery).  For those of you who have had flap surgery (mine will be bilateral), do you think this will be do-able or should I not try to get this gig?  Any advice appreciated!  I just posted on the DIEP thread but you know you (collectively) are my "go to" gang!!

  • Stilts
    Stilts Member Posts: 228

    Kristy: thanks for posting our picture !!! It was so great to meet you in person...hope to be able to meet more of our "loungers" sometime in the future so here's an open lunch invitation if any of you are in the Twin Cities area !!!

    I am really enjoying having my"real" hair back...it grew back in very curly with LOTS of body...quite a change !!!

    Glad to hear you all are doing so well !!!

  • fluffqueen01
    fluffqueen01 Member Posts: 1,801

    Stilts....did you get your letter from Mayo clinic on the trial? I took my name out as I am doing a phase 2 vaccine trial that the army has spear headed.



    Ks...Insurance said scans would be covered, so he has thrown in the towel, although he strongly disagrees. I am thinking I will get the bone scan and then think about the petscan a little and maybe get it at the end of the year.



    Loved the pic. That is pretty much where my hair is too.

  • Jules59
    Jules59 Member Posts: 148

    Just saying, isn't it so great that so many of us are still checking in, keeping track of each other, giving support.  We are a great group.Laughing

    I'll have to update my photo soon.  My hair is very short.  Salt and pepper.

  • ksmatthews
    ksmatthews Member Posts: 743

    Jules can't wait to see a picture of you.  I am so happy we have this group also!  I don't know what I would have done through all of the cancer stuff without you ladies!

  • Colodisneylover
    Colodisneylover Member Posts: 183

    Silia-How is your recovery going from your flap surgery? I hope you are doing well!

  • Silia
    Silia Member Posts: 265

    Hi Colo and all - got home from flap surg on tues afternoon. Yesterday was first full day home. I'm on a high because I'm home, thank goodness. Kay visited me in the hospital bearing a fruit basket - she's as sweetheart as you all already know!!! I wasn't in good shape for the visit but still so appreciated. I still have 4 of 6 drains. Have call into nurse to see if 2 can come out tomorrow. Made a mistake tomorrow trying to cut down pain meds. Will stick to 2 every 4 hrs for a while longer! Haven't pooped since last thurs so something's gonna have to give soon. I didn't eat much of anything until tues so I'm keeping calm that I've only started to put stuff in in the last 2 days... Wish me luck! Live to all. PS has lilylady checked in lately? Chemo is such drudgery...

  • lilylady
    lilylady Member Posts: 478

    First of all some advice for all of you--DO NOT GO SEE THE MOVIE "TED" WITH YOUR 2 TWENTY SOMETHING NEPHEWS!! And sit right between them. Very raunchy and not really all that funny-they disagreed-they kept punching each other and laughing hilariously. I told them if Mark Wahlberg had taken his shirt off at least once I would have been way happier.

    Gosh so many neat postings but if I don't take notes I will miss individuals so I will just generalize or hit on what I remember. I have been off for a while-working way too many hours in the last month and trying to keep my gardens alive has kept me off the computer.

    Silia-so glad you have your surgery done and it went well. Thanks for the PM-I am going to write you back tonight. Pain meds are good for you-it can retard your healing if you are in too much discomfort. Sorry about the bowel thing-pain meds are infamous for the Big C. Mine always goes the opposite direction no matter what it seems. Way easier to regulate it.

    Kristy and Sue-What a great picture of you two and how wonderful you got to meet. I keep scrolling back up to it because it makes me smile. Putting a face to a name makes it more real.

    Jules-I keep reading about this frozen shoulder stuff. I am seeing it on lots of threads. what causes it or what can you do to not get it? I am glad your therapist is helping. I know how you treasure your riding-I hope they can get you "back in the saddle" again (by yourself)real soon. No groaning please-I just couldn;t resist that!!

    Fluff-I am glad you are getting your scans. Problem with them is we all have this random crap floating around in us so if they see something there isn't a real way of knowing if it's cancer or crap unless they scan again to see if it changed size or shape. I have lots of lung mets and when i get my results they are always on the fence on what is cancer and what isn't. The scoring for cancer activity is a subjective thing so even with the Pet they aren't always sure. I hope it gets you the peace of mind you crave and i hope i am not being a total wet blanket. I haven't gotten a bone scan since my first one and I would love to do a brain one because the Her2 loves the brain and I already have cancer in my neck lymph nodes but for now the 3month PET is all he thinks I need. I am certainly in favor on knowing instead of not knowing but it really is a double edged sword. I would love to hear more about that trial you are in also.

    As far as the topless bathing lady. I have a real personal interest in this because I am a non recon person-I might be the only one in the lounge. I did some topless sunbathing at a private pool while on Vac with my girlfriends. The rest of the time I wore some very nice $14 Catalina swimsuits from WalMart that I had cut the shelf bra out of. These girls were pretty horrified so I can imagine the general publics reaction. My reason for doing it was I had always wanted to try it and I also saw it as an educational lesson for these ladies -who aren't always doing their mammos and gyn visits when they should.I should mention we have been best friends for 45 years and very little i do shocks them after all this time.I look like an adolescent boy but my scars are pretty fierce. I am thinking this ladys motivation for doing this at a public pool may be more about the publicity and less about her rights. If her scars bother her that much how can she wear any kind of clothing? She could do many things suit-wise and still enjoy her swim. Thinking she is trying to cash in somehow-hate to say that about a sister but it just doesn't ring true. I encourage all of you to check out a web site called "The Scar Project". It is 3 survivors who agreed to be photographed for a traveling art exhibit. I saw it in Cicinnati last summer right after my BMX. It is both moving and scary and so emotional. Some of the photos are extremely larger than life-right in your face-and the majority of the exhibit go-ers gasped when they first walked in. Ties right in with this lady wanting to be "in your face" with her scars in a public place. In a museum it is art-in public it is what?

    Penny-did I miss your report on how your trip went? You lead such a neat life and have been so many places. You seem like a real dynamo.

    I am having my scan on Friday the 13th-I was dxed on Fri/13 also. My April scans weren't all good news but we decided to stay the course on current meds for another 3 months. We discussed what we will move on to if we don;t get absolute stable or some real regression. I did post abut the new Her2 stuff that got approved on June 6. We will probably try for that pending insurance approval. I am hoping to get some more life out of my current stuff because I can function fairly well on it. The new stuff Pertuzumaub or I think they are going to call it Perjeta (sounds cute/like something you would name your kid or puppy) has to be paired with a Taxol-a name most of us are familiar with from last summer. Glad that we have this exciting new drug but dreading the whole hair loss/neuropathy/nail thing. Maybe without the other 2 drugs i took with it last summer it won;t be so bad. Anyway focusing on the positive-I feel great and I look great too. I am strong and have energy (thanks to ritalin) and am out there doing as much as I can!! I will certainly report my results-praying for NED of course but Regression or Stable will work also.

    As usual I can always make a short story long...thanks for your tolerance. You ladies really are the best

  • Huskerkkc
    Huskerkkc Member Posts: 471

    Silia & Lilylady,



    So good to hear your updates an know you're still checkin in and staying in touch. I is hotter than HELL here. Heat index of 108 today. Yikes. I was outside watering flowers (starting to be a lost cause) and tslkinvo neighbor. Have mild sunburn on neck/upper chest after 20 minutes!

    Miserable.

    Will be going to Germany in two weeks. Goin o stay with ou foreign exchange student and her family from2 years ago. Excited but nervous. Leaving DS (16) w/older sisters. They will be just fine but lots to do it seems to get organized.

    Hope you are staying cool and collected. I hope you get to do some of the things you were unable to do last year or that you have plans to do so soon. One year Ago started rads, driving 95 miles one way for a10 minute procedure, 33 times. How did we do all we did and are still doing? We. Are. AWESOME!

  • fluffqueen01
    fluffqueen01 Member Posts: 1,801

    Lily...it is great to hear from you. I hope your scans are good on the 13th. The onc says if I get a Pet scan, I don't need to get a bone scan. Since I had to fight like crazy for the pet scan, I think I will go with that. Does a pet scan not cover your brain? I just assumed it was your whole body. Guess I better do a little more research.

     Here is an article that my oncology nurse for the trial I am in sent me. It is really interested. I am heading out for my fourth session tomorrow evening. Two more two go in the next eight weeks, and then a break for 6 or 7 months. Sorry about the way it inserted.

    Hope everyone is doing well. Tonight is finally a smidge cooler. It has been so hot, I couldn't tell my hot flashes from the normal heat!  LOL

    Evidence that HER2 Peptide Vaccine Can

    Delay Recurrence in Early Breast Cancer

    CHICAGO-A HER2 peptide
    vaccine called AE37 triggers
    strong immune responses in patients
    with early breast cancer,
    researchers reported here at the American
    Association for Cancer Research Annual
    Meeting. Preliminary data also suggest the
    vaccine may prolong disease-free survival,
    although the difference between the vaccine
    and control groups has not reached
    statistical significance in the randomized
    phase II trial (Abstract LB-218).
    In a previous phase I study, researchers
    found that the AE37 peptide vaccine
    plus granulocyte-macrophage-stimulating
    factor (GM-CSF) was safe and triggered
    activation of CD4-positive T cells with
    anti-tumor activity. In the current study, investigators
    randomly assigned 217 women
    with early breast cancer to either AE37 plus
    GM-CSF or GM-CSF alone. All patients
    had completed standard therapy and were
    disease-free at the time of enrollment, but
    were at high risk of recurrence.
    With a median follow-up of 22 months,
    90% of patients in the vaccine arm remain
    disease free compared with 82.6%
    of the controls. When the investigators
    restricted their analysis to just those patients
    with low-HER2 expressing tumors,
    the trend for benefit with the vaccine was
    even greater, although still not statistically
    significant (88.6% remaining disease free
    compared with 69% in the control arm,
    p=.134). "There is approximately a 40% reduction
    of recurrence for those [low-HER2]
    patients specifically," said Diane F. Hale,
    MD, a research resident in general surgery
    at Brooke Army Medical Center,
    who presented the study. "We have seen
    similar benefits for low expressors in
    our other vaccine studies as well." That
    pattern is important because it means a
    vaccine might be useful in a larger proportion
    of patients with breast cancer
    than currently available drugs that inhibit
    HER2. "Whereas Herceptin is available
    only to about 20% of breast cancer patients,
    this vaccine could be used in 50 to
    60 percent of patients."
    When asked during a news conference
    at the meeting about the lack of statistical
    significance in the disease-free survival
    data, she noted that the current followup
    is still relatively short. "We will follow
    these patients to three years after therapy,
    so we still have time to see if there is a
    significant difference." Furthermore, the
    Phase III trial is set to enroll 700 patients,
    and is designed to detect difference in clinical
    outcomes.
    Toxicities Mostly Low Grade
    All of the toxicities thus far have been low
    grade, with the exception of one patient
    who developed Grade 3 flu-like symptoms,
    Hale said, adding that there has not been
    any evidence of cardiotoxicity, as has been
    associated with trastuzumab treatment.
    Vaccination also correlated with
    changes in the immune system. In a
    delayed-type hypersensitivity skin test,
    women immunized with AE37 plus
    GM-CSF were significantly more like to
    have a 5 mm or greater response compared
    with those who received GM-CSF alone
    (86% vs. 27%). Additionally, women who
    received the vaccine were more likely to
    have a substantial drop in the number of
    regulatory T cells, compared with women
    in the control group. Because regulatory
    T cells suppress immune responses, the
    decline detected after immunization suggests
    that the vaccine may help overcome
    immune tolerance.
    "Their results are more impressive
    than I expected," said the news conference's
    moderator, Olivera Finn, PhD,
    Distinguished and Chair of Immunology
    at the University of Pittsburgh School of
    Medicine. "I am usually very pessimistic
    because, to me, even early disease is
    still cancer that may have been there for
    quite a while influencing the immune system.  However,
    my expectations have been
    mostly theoretical since we are just now
    beginning to test vaccines in early disease.
    "Up until now [nearly all of the vaccines
    have] been tested in more advanced
    disease," she continued. "From a limited
    number of examples, we are confirming,
    with data, that early is better than late. The
    question now will be ‘How early?'"
    Unlike other immunotherapies that
    have gained FDA approval in recent years,
    which are very expensive (e.g., sipuleucel-T
    at $93,000 and ipilimumab at $120,000
    per course), the cost of AE37 should be
    much more affordable, according to Eric
    Von Hoffe, PhD, President of Antigen
    Express, the company developing the vaccine:
    "It is fully synthetic. There are no
    biological reactions necessary to generate
    it, so it is much more cost effective than
    cellular-based therapies." O
    T

  • fluffqueen01
    fluffqueen01 Member Posts: 1,801

    Lily...it is great to hear from you. I hope your scans are good on the 13th. The onc says if I get a Pet scan, I don't need to get a bone scan. Since I had to fight like crazy for the pet scan, I think I will go with that. Does a pet scan not cover your brain? I just assumed it was your whole body. Guess I better do a little more research.

     Here is an article that my oncology nurse for the trial I am in sent me. It is really interested. I am heading out for my fourth session tomorrow evening. Two more two go in the next eight weeks, and then a break for 6 or 7 months. Sorry about the way it inserted.

    Hope everyone is doing well. Tonight is finally a smidge cooler. It has been so hot, I couldn't tell my hot flashes from the normal heat!  LOL

    Evidence that HER2 Peptide Vaccine Can

    Delay Recurrence in Early Breast Cancer

    CHICAGO-A HER2 peptide
    vaccine called AE37 triggers
    strong immune responses in patients
    with early breast cancer,
    researchers reported here at the American
    Association for Cancer Research Annual
    Meeting. Preliminary data also suggest the
    vaccine may prolong disease-free survival,
    although the difference between the vaccine
    and control groups has not reached
    statistical significance in the randomized
    phase II trial (Abstract LB-218).
    In a previous phase I study, researchers
    found that the AE37 peptide vaccine
    plus granulocyte-macrophage-stimulating
    factor (GM-CSF) was safe and triggered
    activation of CD4-positive T cells with
    anti-tumor activity. In the current study, investigators
    randomly assigned 217 women
    with early breast cancer to either AE37 plus
    GM-CSF or GM-CSF alone. All patients
    had completed standard therapy and were
    disease-free at the time of enrollment, but
    were at high risk of recurrence.
    With a median follow-up of 22 months,
    90% of patients in the vaccine arm remain
    disease free compared with 82.6%
    of the controls. When the investigators
    restricted their analysis to just those patients
    with low-HER2 expressing tumors,
    the trend for benefit with the vaccine was
    even greater, although still not statistically
    significant (88.6% remaining disease free
    compared with 69% in the control arm,
    p=.134). "There is approximately a 40% reduction
    of recurrence for those [low-HER2]
    patients specifically," said Diane F. Hale,
    MD, a research resident in general surgery
    at Brooke Army Medical Center,
    who presented the study. "We have seen
    similar benefits for low expressors in
    our other vaccine studies as well." That
    pattern is important because it means a
    vaccine might be useful in a larger proportion
    of patients with breast cancer
    than currently available drugs that inhibit
    HER2. "Whereas Herceptin is available
    only to about 20% of breast cancer patients,
    this vaccine could be used in 50 to
    60 percent of patients."
    When asked during a news conference
    at the meeting about the lack of statistical
    significance in the disease-free survival
    data, she noted that the current followup
    is still relatively short. "We will follow
    these patients to three years after therapy,
    so we still have time to see if there is a
    significant difference." Furthermore, the
    Phase III trial is set to enroll 700 patients,
    and is designed to detect difference in clinical
    outcomes.
    Toxicities Mostly Low Grade
    All of the toxicities thus far have been low
    grade, with the exception of one patient
    who developed Grade 3 flu-like symptoms,
    Hale said, adding that there has not been
    any evidence of cardiotoxicity, as has been
    associated with trastuzumab treatment.
    Vaccination also correlated with
    changes in the immune system. In a
    delayed-type hypersensitivity skin test,
    women immunized with AE37 plus
    GM-CSF were significantly more like to
    have a 5 mm or greater response compared
    with those who received GM-CSF alone
    (86% vs. 27%). Additionally, women who
    received the vaccine were more likely to
    have a substantial drop in the number of
    regulatory T cells, compared with women
    in the control group. Because regulatory
    T cells suppress immune responses, the
    decline detected after immunization suggests
    that the vaccine may help overcome
    immune tolerance.
    "Their results are more impressive
    than I expected," said the news conference's
    moderator, Olivera Finn, PhD,
    Distinguished and Chair of Immunology
    at the University of Pittsburgh School of
    Medicine. "I am usually very pessimistic
    because, to me, even early disease is
    still cancer that may have been there for
    quite a while influencing the immune system.  However,
    my expectations have been
    mostly theoretical since we are just now
    beginning to test vaccines in early disease.
    "Up until now [nearly all of the vaccines
    have] been tested in more advanced
    disease," she continued. "From a limited
    number of examples, we are confirming,
    with data, that early is better than late. The
    question now will be ‘How early?'"
    Unlike other immunotherapies that
    have gained FDA approval in recent years,
    which are very expensive (e.g., sipuleucel-T
    at $93,000 and ipilimumab at $120,000
    per course), the cost of AE37 should be
    much more affordable, according to Eric
    Von Hoffe, PhD, President of Antigen
    Express, the company developing the vaccine:
    "It is fully synthetic. There are no
    biological reactions necessary to generate
    it, so it is much more cost effective than
    cellular-based therapies." O
    T

  • deedee2
    deedee2 Member Posts: 78

    Hi ladies,

    It's been awhile since i've checked in, but i think of you all often.

    Kristy and Sue what a lovely photo. You ladies look great. I'm like Lily i keep looking at the photo and smiling. That had to be so much fun and exciting for you two to meet. I wish we could have some type of reunion where all of us get together and share stories, laugh and just have a good time with each other.

    Kristy enjoy your trip to Germany.

    Lily, i pray that you get good results from your scan on Friday.

    Silia glad your surgery went well and i hope the pain is easing up. i need to schedule another recon surgery. I think my implant is to big because it hurt quite a bit, i don't know if that is healing pains or if the darn thing is just to big. I'm not sure if the insurance will pay for me to get a smaller implant. I have to schedule surgery on side that was lifted so it will match a little more. Right now i am visibably lopsided.

    Fluffqueen thanks for the article, i was her2 positive so i try to stay up on reports and studies on it.

    Well ladies i wanted to say hello to everyone,  I haven't had a chance to catch up with what's going on with all of you, but i did want to say hello to you all.

    Take care!!