INSOMNIACS place to talk in the wee hours
Comments
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Jazzy - You are so sweet! Thank you! You all have done so much for me already! Surgery is Friday at 730am
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((((HUGS)))) Deb. You know we're in your pocket.
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den, will b praying for you Friday. Hang in there
Pp, great pics. Cute kids!! Hope you have a bit more energy:)
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Rosie posie posted on the thread death and dying issues if anyone wants to read her post. About 5 hours ago I thnk
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deb. Hugs
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Thank you for the hugs! xo xo xo
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Oh Deb, I am sorry for the heavy burden you are carrying. Anxiety and fear do weigh us down. Big hug.
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Patty, your boys are big now. They look so different from the pic you posted last year. Good you are feeling a bit better. Watch for dehydration and UTI.
Kath, thank you for pointing that out. Will copy and paste the article. It is a small study, but seems interesting. More research is needed.
Goats, Charlotte looks like a fox.
Here is the article.
High-Dose Vitamin D Shows Promising Effects in MS
Patients with multiple sclerosis (MS) who took high doses of cholecalciferol (vitamin D3) had increased blood levels of 25-hydroxyvitamin D levels [25(OH)D] to those proposed to be sufficient in MS and showed promising immunologic changes, in a new study.
The study, published online in Neurology on December 30, was conducted by a team led by Peter A. Calabresi, MD, Johns Hopkins University School of Medicine, Baltimore, Maryland.
"Future studies are warranted to further elucidate the molecular mechanisms of these effects and ongoing randomized controlled clinical trials will be instrumental to establish the clinical utility of cholecalciferol as a novel immunomodulatory therapy for MS," the authors conclude.
They note that low serum 25(OH)D levels are associated with an increased risk for MS and in established disease are associated with increased disability and disease activity. In addition, animal studies of vitamin D supplementation show treatment can prevent or ameliorate experimental autoimmune encephalitis, a murine model of MS.
They conducted the current study to investigate the immunologic effects of high-dose vitamin D in patients with MS.
For the study, 40 patients with relapsing-remitting MS were randomly assigned to receive high-dose (10,400 IU) or low-dose (800 IU) cholecalciferol daily for 6 months. Baseline levels of serum 25(OH)D were 27 ng/mL in both groups, but the high-dose group had a much greater increase (mean increase of 34.9 ng/mL) compared with the low-dose group (6.9 ng/mL).
The authors explain that optimal levels of serum 25(OH)D in MS are currently unclear, but it has been proposed that levels between 40 and 60 ng/mL may be the best target for this population, which such levels being achieved with the high dose of cholecalciferol given in this study, but not with the low dose.
In terms of immunologic effects, patients taking the high dose of cholecalciferol showed a reduction in the proportion of interleukin (IL)-17 CD4+ T cells, CD161 CD4+ T cells, and effector memory CD4+ T cells, which are believed to be major contributors to the immunopathogenesis of MS. The high-dose group also showed a concomitant increase in the proportion of central memory CD4+ T cells and naive CD4+ T cells. None of these effects were observed in the low-dose group.
The researchers write: "Our finding that high-dose cholecalciferol leads to a decrease in the proportion of CD4+ IL-17+ T cells in the peripheral blood of patients with MS suggests that this may be a major mechanism underlying the possible therapeutic role of vitamin D in MS."
In terms of adverse effects, the authors report that these did not differ between the two groups, and there was one MS relapse in each treatment group, leading them to conclude that the high dose was "safe and well-tolerated."
However, commenting on the findings for Medscape Medical News, Alberto Ascherio, MD, Harvard Medical School, Boston, Massachusetts, was more cautious.
Noting that 4 (21%) of the 19 patients allocated to high-dose vitamin D had to stop (n = 3) or reduce (n = 1) the treatment because of side effects, he said, "I would be cautious to conclude that the study provides conclusive evidence that supplementation with 10,400 IU/day is safe and well-tolerated, as this statement may induce some MS patients to take this relatively high dose without appropriate supervision."
Dr Ascherio added that he thought the study was "interesting" but "the results are at risk of being overinterpreted."
"The study identifies some potential mechanisms by which vitamin D could affect the course of MS, but it does not provide evidence on whether supplementation at this high dose is beneficial to patients with MS," he noted.
The study was supported by the Kenneth and Claudia Silverman Family Foundation, Montel Williams Foundation, and National Multiple Sclerosis Society.
Neurology. Published online December 30, 2015. Abstract
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Loveroflife - thank you for understanding and for the adorable hug! That made me smile! xo
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Spookie, the spoons are sort of like a Christmas ornament - they're shiny, you can hang them up...
((Deb)) Please let us know how things go when you can. We will be with you on Friday.
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Deb- thanks for letting us know your surgery date and time. Keeping you in my prayers for all to go well on Friday and good outcomes sister.
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Susan, thank you for pointing the way to Rosevalley's post. She has been on my mind. I'm relieved to hear she is more comfortable now.
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You guys are the best! I appreciate the prayers and well wishes. I just wish this was over already.
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Loveroflife, Interesting article. The pacific northwest has the highest incidence of MS in the nation. Wonder if low vit D might be part of the problem. We generally have sunny weather in Aug & Sept, but the rest of the year it is either raining, cold, or both. I have read that people in the northwest should just take Vit D because we live here.
Deb, We know what you mean. The waiting is the hardest part. Hugs.
Susan, I thank you also for letting us know Rose posted. From what she said, her DH is totally denying how sick she is. I know someone whose DH was like that. He was talking about the cruises they were going to take a week before she passed.
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my DD with her DGD. Evie is going home tomorrow. I took DGD shopping, she hadn't bought any nursing bras yet. I ask if she was anxious to get the baby home, she said she was excited.
Deb, keeping fingers crossed. I think your pocket is going to be very crowded!
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you and your daughter are..twinzies...such great pictures!!
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DEB with you.
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I'm Baaaaaaccccccckkkkkkkk!!!!!!!!!!!!!!!!!!!!!!!!!!
Sorry to have been gone for a while but was really busy the last two months between school and other things.
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well let me be the first to welcome you back...I am the true insomniac on this thread...lol. 0 -
that's us pretty owlettes welcoming you back. Hope you had fun while you were awayThis is you coming in for a landing.
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We are watching you. 0 -
Nice! Thanks for the welcome back, I missed all you gals!
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I am a bit sleep deprived. It's 5 in the morning. I should prob just do an all nighter. 0 -
It's 6 here at my house.
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when you have time, gotta fill us in on what we missed. Welcome back
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Real life crept in and threw me for a loop. The class I was taking really got crazy towards the end, was sick with two colds back to back and assorted other junk.
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ohhhhh. Hope you are feeling better. Wish you had a cool story about being away and traveling, having the time of your life!!! But we can all dream...right0 -
Feeling good. Finally kicked the colds to the curb at Christmas. Snowfall here has pretty much been nothing. Had 60s and 70s here Christmas Eve and Christmas Day. Might see some snow this week, but right now its raining today
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Debs best wishes for surgery. XXX
Patty - what lovely boys, very handsome.
Cubbie, Arthur isn't tiny but is quite a small (compact) cat.
Smaarty your DD's love and pride are just beaming out of that photo - gorgeous! Exactly as a new grandma should look
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https://www.youtube.com/watch?v=tiljsbrL0_8