Triple Negative Stage IV
Comments
-
I also have good results to announce: my quarterly pet/ct scan continues to show stable disease in my bones and nothing in the organs. Yippee! I'll take that. I wish the bone SUVs were going down instead of slightly climbing, but I've had to redefine my definition of stable disease.
Congrats, hartrish.
0 -
winning: wonderful news
0 -
Excellent news Hartrish! So glad you're having great results!!
Katherine
0 -
Glad to hear all the good news on this thread! Keep it coming!
I finished a 20 day treatment of radiation to my chest 2 weeks ago. It wasn't too bad, other than fatigue. My oncologist is moving me on to Keytruda. Anyone have experience with this drug? My insurance has refused to cover it so tomorrow I'm filling out the forms to submit to Merck the manufacturer to see if I qualify for assistance. I sure hope so!
0 -
Minxie, I started a discussion on Keytuda and Havalin...I take both, but beside the neuropathy I think most of my symtoms are from the keytruda since they happen after I receive it and not so much with the Havalin. I'm on the way to bed, we took 10, 10 yr olds to a water park today for a late birthday party....if you don't get your answers there feel free to private message me.
KPW3
0 -
minxie: I have not been on keytrude yet. Hoping to include immunotherapy in next set of drugs when/if carbo and Gemzar quit working. Keep us informed how you are doing on it
0 -
Here is a research study that included TNBC participants. EMBRACA trial: "The trial found that talazoparib provides a significant clinical benefit to all patient subgroups, including those with hormone receptor-positive and triple-negative disease. The results of this trial are quite exciting and indicate talazoparib is a novel treatment option for patients with metastatic breast cancer and BRCA mutations."
The median progression-free survival was 8.6 months for patients in the talazoparib arm, vs 5.6 months for those in the physician's-choice arm, and this difference was statistically significant (hazard ratio [HR] = 0.542, P < .0001). Patients in the talazoparib arm were 45.8% less likely to have disease progression, compared with those in the physician's-choice arm (http://www.ascopost.com/News/58335).
Overall response rate and clinical benefit rate at 24 weeks showed a statistically significant improvement for those in the talazoparib arm compared with those in the physician's-choice arm: The overall response rate was 62.6% for patients in the talazoparib arm, vs 27.2% for those in the physician's-choice arm (HR = 4.99, P < .0001). Twelve complete responses were observed in the study, all in the talazoparib arm. The clinical benefit rate at 24 weeks was 68.6% for patients in the talazoparib arm, vs 36.1% for those in the physician's-choice arm (http://www.ascopost.com/News/58335).
PARP Inhibitor Improves Progression-Free Survival in Patients with Advanced Breast Cancers
http://www.hopkinsbreastcenter.org/artemis/201809/...
Is anyone on a PARP inhibitor? If so, can you share your experience with us?
Thank you
Tricia
0 -
Very interesting....I’d be interested, but don’t have the BRACA Mutations.
0 -
how is everyone doing?
0 -
I just got my post-rads CT report. The area in my lung that they radiated did quite well - went from 7 cm down to 2. But the area at the bottom of my lung that they didn't radiate continued to grow, and now some new masses have popped up in the lymph nodes by my kidney
My radiation oncologist is going to talk to my regular onc and decide if we do more radiation to the rest of my lung. Right now I'm scheduled to start Keytruda next Tuesday. For those of you who have done Keytruda alone, without any other chemos - how did your hair hold up? Thanks KPW3, I'll post on that thread as well!
0 -
minxie: glad the radiation worked well on the one tumor. Why did they decide to just give you keytrude without chemo? Just curious. I hope the radiologist and onc decide about more radiation or the next steps. Hugs and prayers your way.
Tricia
0 -
my tumor marker CA29.27 was stable this week. 54.4. Praise the Lord. Next mri and scan is oct 17th.
0 -
Copied from Lumpie from another thread Just in case your are not on that thread
Sep 20, 2018 11:02AM Lumpie wrote:
Long-Term Clinical Outcomes and Biomarker Analyses of Atezolizumab Therapy in Metastatic Triple-Negative Breast Cancer- Study published in: JAMA Oncology
- https://www.practiceupdate.com/C/73363/56?elsca1=e...
0 -
Hi Hartrish, thank you for copying that post from Lumpie. Some great info there. I'm glad you're doing well on carbo/gemzar! That's great news!
Mom will find out if she's eligible for a double blinded study for immunotherapy (atezolizumab or placebo and paclitaxel) on Wednesday. Not sure about the paclitaxel for stage iv tnbc. There's a 2:1 ratio she receives the immunotherapy, really hoping we get it. Always thinking about the next step here.
Minxie, I wish you all the very best with Keytruda. I asked our trial onc about keytruda and she said that a single session cost thousands of dollars, we're in Toronto Canada.
Has anyone heard of the immunotherapy Maraba? Or had experience with it?
Prayers and peace,
Katherine
0 -
kcan: I have not heard of using Maraba as immunotherapy. I did look it up after your post. Here is a link to some info.
https://medicalxpress.com/news/2018-01-viruses-cancer-immunotherapy.html
Was that a trial your mom was looking at? Is there one for TNBC?
0 -
Maraba is an oncolytic virus (sorry, my mistake). Maraba delivered in combination with a checkpoint inhibitor has shown promise in mice.
Here is the article
https://news.oicr.on.ca/tag/maraba/
Mom is still interested in Maraba however, I consulted with Cancer Commons and they suggested enrolling in clinical trials involving different immunotherapies as Maraba is still very new. Here is a clinical trial in Toronto Canada, she was not able to participate in this trial at the time.
0 -
What treatments have you used after captibine (zelota) stopped working after almost 4 years? Triple Negative, metastatic
0 -
Suzitozer: I have only been on carbo and gemzar so can not address your question. Hope someone on the thread can answer your question.
Take care
Tricia
0 -
My wife's ER/PR+ turned triple negative some 2 years back with extensive mets to the spine and hips. She was on Capecitabine(Xeloda) for about 18 months. It slowly began to fail until there was major bone progression. Her oncologist had good luck with patients that had a previous fail on Capecitabine and prescribed eribulin (Halaven). My wife has been on eribulin for 4 months or so (2 push injections for 2 weeks then one week off cycle).
She just got the results of her recent PET/CT scan yesterday, her birthday. NED!, cancer is gone! OMG! She was triple negative stage 4, not a good diagnosis now NED or cPR to some. Doing happy dance now.
0 -
Mike, first and foremost congratulations on your wife and families beautiful blessing. That’s tremendous news! I hope that your wife is NED for as long as it takes for a more permanent answer to this crappy disease comes along.
I was curious about how you guys discovered that her receptor status had changed? Is it normal to keep doing biopsies?
More broadly, do people usually get their mets biopsied? My mom had scans after her primary biopsy, but I feel that i read on here a lot about people getting distant mets biopsied...0 -
My wife's case is very complex. At one point she had 3 different breast cancers at once. In her breast was a large ER/PR+, 100% estrogen, Grade 1. Inside that was an ER/PR+ 30% grade 3. In 9 of her 19 lymph nodes removed was triple negative metaplastic breast cancer. Lifetime AC and radiation got rid of that mess. Estrogen blockers failed to stop the cancers return. A biopsy was done on a met to her hip which showed it 2% ER/PR+ and the rest TNBC.
0 -
Mike3121 - congrats to your wife on being NED, and getting the news on her birthday - hurrah! What is her medical team saying about her treatment plan? Is she going to continue with eribulin until her next scan? I was diagnosed with 2 liver mets in January, then started GemCarbo. I had an NED scan in April and again in July. My next scan is in a couple of weeks, and if it's NED, then plan is to stop chemo. I too had a very ER+ cancer that became TN when it metastasized.
Skyfly - Only speaking from my own experience... I was initially diagnosed stage 3 with highly ER+ IDC. I was on faslodex/ibrace/lupron when we discovered the liver mets. My oncologist ordered a biopsy and we found out the mets were TN. Based on what I read on boards, it does seem that people have recurrences biopsied from time to time, especially if there is reason to suspect that receptor status may have changed due to an unexpected response to treatment, for example.
0 -
thrivingmama. "What is her medical team saying about her treatment plan?"
She has an appointment this coming Thursday.
0 -
I haven't been on in quite sometime. I am currently NED. I have been for around 9 months. My questions is who on here has been NED the longest?
0 -
mike3121: congratulations to you and your wife. Wonderful news.
Skyfly: people will usually get re-biopsies after treatment failure. The thought is the cancer has mutated and may have changed status. Also some do Gemonictesting from Caris or Foundation One to see if any target drugs are identified for treatment.
Tricia
0 -
ksmatthews, there is the topic: Stage 4 NED crew, let’s support each other. There are other NED stage 4 community members there.
0 -
I have come here several times but could not write any word because I thought may be there are ways to revert what has happened. She is out there and if I say it out loud, she will leave. Truth is so harsh and reality is so spontaneous, they always leave us to admit the most difficult things in easiest way, No matter how hard we try to avoid it.
My mother has passed away on last 17th of September at evening. Everyone in the family is devastated with her untimely demise. We are trying to find peace thinking that all of her sufferings came to an end and she is in a better place now. She was brave and fought valiantly for last 2years.
Thank you everyone in here for your constant support each time I was here with my queries. Your Love and support made this difficult cancer journey easier for us.
0 -
Sharjin, words cannot express how sorry I am for you, your family and your dear mom. This disease is so cruel. You were with your mom every step of the way, provided her with comfort, unconditional love and were such a strong advocate.
I followed your posts adamantly, you have given me such strength and courage to do the same for my mom. You are not alone, my heart and prayers are with you and your family. Thank you for posting. I am always hear to listen.
Gentle hugs and prayers,
Katherine
0 -
Sharjin, I'm very sorry to hear that your mother passed away. I'm sure you're heartbroken, but am glad that she had someone so loving to care for her as her health declined.
With Sympathy, Lyn
0 -
Sharjin, I'm too so sorry to hear of your mother's passing, it's so hard to lose a parent. You and your family will be in my prayers.
0
