Breaking Research News from sources other than Breastcancer.org
Comments
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seems like the evidence so far is pointing to higher BMI = less taxane effectiveness
Well, I was in the high overweight BMI when I did Taxol and I had a great response, then again I was also on Herceptin and Perjeta so maybe that matters.
This definitely needs further study.
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This is interesting:
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Lumpie, How're you doing? We who appreciate this thread thank you and wish you a happy new year!
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Hi santabarbarian! I am ok, thank you for checking....and I am very glad that you and others appreciate the topic/board. I have a couple of things I need to post. The new-ish med I am on is doing a job on my digestive system and I feel like I am always behind/moving in slow motion. Hope you are well and.... at this point, I am almost reluctant to speculate about how the year might ging.... but hope you ... and eveyone else, too!.... have a healthy and happy new year!
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I say thank you too. This is the thread I check on nearly every day. Often the only one I check. I appreciate the work it takes to aggregate this information.
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Me too - Thanks Lumpie.
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Lumpie,
I hope you’re feeling better. I wanted to chime in and agree with the rest of the group that I definitely appreciate all the effort you put into this topic. Thank you
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Yes. Thank you, Lumpie!
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Me, too, Lumpie...thanks so very much! A much-needed forum!
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Thank you for the post on gut health. We are complex animals and many things seemed to get overlooked, dismissed, or are poorly understood. The bacdterium mentioined, Bacteroides fragilis, normally in the colon wrecks havoc elsewhere, unsurprisingly. But does it escape unnoticed? Lifestyle is so important. Is kimchi, sour kraut, yogurt etc enough for a healthy gut?
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Thank you Lumpie for your tending of this post! I too sometimes come to the site just to read the latest updates on this post
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Adding my voice to the choir thanking Lumpie. I also follow this thread closely.
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NCI aims to track BC recurrenceSharing this - long overdue -
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As always Lumpie, you know we appreciate you! And also the growing group of folk who regularly post here...you’ve inspired them!
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I will add my thanks Lumpie. I check this thread at least once a day!
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Thank you Lumpie!
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t Lumpie- glad to “see” you - we missed you while you were out recuperating .
Recommended treatment graph for metastaticDee
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thanks Lumpie and all who contribute. That flow chart for metastatic BC was very interesting thanks Dee.
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Thank you so much, everyone, for your kind and encouraging comments! You have made my week and I truly appreciate it.
-Lumpie
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Shorter radiotherapy promising in breast cancer
Women with early invasive breast cancer who underwent one-week high- or low-dose hypofractionated adjuvant whole-breast radiotherapy regimen had similar five-year ipsilateral breast tumor relapse rates and safety outcomes, compared with those who received the standard three-week regimen, according to a study presented at the European Society for Radiology and Oncology 2020 Online Congress and published in The Lancet. The findings suggest the safety and efficacy of hypofractionated radiotherapy regimen as the new standard for early invasive breast cancer, said researcher Joanne Haviland.
https://www.mdedge.com/hematology-oncology/article...
https://www.thelancet.com/journals/lancet/article/...(20)30932-6/fulltext
DOI:https://doi.org/10.1016/S0140-6736(20)30932-6
{Report courtesy of AANP Smart Brief; Lancet article appears to be available w/o charge.}
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COVID-19 Vaccine & Patients with Cancer
ASCO commentary on the covid-19 vaccine for cancer patients.
In short...
Are there people who should not be vaccinated?
At this time, only those with contraindications to a specific vaccine component should not be offered vaccination with that specific product. These contraindications are described in detail on the CDC's vaccination clinical considerations page.
... patients undergoing treatment may be offered vaccination against COVID-19 as long as any components of the vaccine are not contraindicated.
https://www.asco.org/asco-coronavirus-resources/co...
{I believe that this page is publicly available. If not, let me know and I can post details.}
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Older women with early breast cancer may be able to avoid radiation after surgery
The omission of radiation therapy after breast-conserving surgery did not affect survival among certain older women with early breast cancer, according to results presented at the virtual San Antonio Breast Cancer Symposium.
Radiation therapy reduced the rate of ipsilateral breast tumor recurrence among women aged 65 years or older with hormone receptor-positive disease who underwent wide local excision and were receiving adjuvant hormonal therapy.
However, radiation therapy receipt did not affect rates of distant metastases, contralateral breast cancer or OS, 10-year data from the randomized phase 3 PRIME II trial showed.
https://www.healio.com/news/hematology-oncology/20...
Source: Kunkler IH, et al. Abstract GS2-03. Presented at: San Antonio Breast Cancer Symposium (virtual meeting); Dec. 8-11, 2020.
{Access to coverage should be free of charge. Registration may be required.}
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Symptoms often underrecognized among patients receiving radiotherapy for breast cancer
Symptoms such as pain, fatigue and pruritus often went underrecognized among patients with breast cancer treated with radiotherapy, according to study results presented at the virtual San Antonio Breast Cancer Symposium.
Black patients and younger patients appeared at significantly higher risk for symptom underrecognition, results showed.
"We were disappointed to find that physicians frequently didn't recognize the severity of the symptoms patients themselves reported they were experiencing," Reshma Jagsi, MD, DPhil, Newman family professor and deputy chair of the department of radiation oncology and director of Center for Bioethics and Social Sciences in Medicine at University of Michigan, told Healio.
"Because physicians cannot help patients if they don't know who is suffering, improving symptom detection appears to be a way to improve the quality of care and to reduce disparities in cancer treatment experiences and outcomes," Jagsi added. "The findings also suggest that clinical trials should not rely on physician reports alone to evaluate the side effects of treatments; patient-reported outcomes provide an important complement to physician evaluations."
https://www.healio.com/news/hematology-oncology/20...
Source: Jagsi R, et al. Abstract GS3-07. Presented at: San Antonio Breast Cancer Symposium (virtual meeting); Dec. 8-11, 2020.
{Access to coverage should be free of charge. Registration may be required.}
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LilyisHere.. This is the study my MO told me about. I am currently in year 7 with the end being this December. She and I agreed to extending two years instead of 5 with us discussing it at the end of 7. Reading your link I fall into the high ER and low grade tumors giving me an "excellent prognosis" which would explain the positive attitudes of all my doctors. I'm debating whether to continue to year 10. I wonder if there is any place you can see just how toxic the AI's are. That would help in my decision. Has anyone seen this ?
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HHS Tells States to Open Vaccine Access to Vulnerable Adults
— Given healthy vaccine supply, second doses will no longer be withheld, says HHS Secretary
January 12, 2021
...Azar said it was time to broaden the scope of eligible recipients, and to expand the number and type of delivery sites. He outlined the administration's plans to carry out the following actions:
- Direct states to expand the populations eligible to receive COVID vaccine doses to those ages ≥65 and those ages <65 with comorbidities as validated by medical documentation (the latter will be determined by state governors)
Azar outlined the reallocation of vaccine doses to those states that are most effective in administering them, based on self-report, and to those states with the greatest numbers of adults who are over age 65. In 2 weeks, allocations will no longer be determined simply by a state's population but by the percentage of vaccines administered compared to the allocation a state received, he explained.https://www.medpagetoday.com/infectiousdisease/cov...
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Lumpie,
Thanks for posting. I just wrote to our governor and our county executive about this (I live in Maryland) -- so far they are sticking to their guns about the original distribution schedule. Hope this changes.
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After 48 Years, NCI Aims to Track Breast Cancer Recurrences
Change to SEER Eventually Planned
January 08, 2021
Patients with breast cancer want accurate information on the risk of their cancer recurring once they have completed treatment.
But those statistics have not been available from a robust population-based source.
Now, there is hope that they will ― at last ― be collected.
A new pilot project at the National Cancer Institute (NCI) is setting out to collect that information, although the researchers say it is a "long-term goal" that will take a few years.
But it has already been a long time coming. The mother lode of all US cancer data, the NCI's Surveillance, Epidemiology, and End Results (SEER) Program, started collecting cancer data in 1973.
{The SEER} database has never included information on cancer recurrence.
The NCI now has a "long-term goal" to implement additional "data elements" into SEER that will allow calculation of breast cancer recurrences...
Breast cancer advocates have long been calling for SEER to count recurrence, including metastatic recurrence.
https://www.medscape.com/viewarticle/943796?fbclid...
{Free access to reporting. Registration may be required.}
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Lumpie - thank you for posting NCI starting to track/examine recurrence probability. Increadible that this is not being done. It seems like it could really influence treatment. I've been told that even if tumor from time 1 to time X were compared, cancer mutates so much, that it might be difficult to know if it is recurrence, a new cancer, or maybe even if the original cancer was not irradicated the first time. I wonder to if monitoring would be more rigorous and able to catch cancer recurrence/new cancer sooner.
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Have you seen this? A clinical trial with your own MO.
Thanks Christine Hodgdon at https://thestormriders.org/ for posting this on Twitter
If you have the SF3B1 mutation, you may be eligible for the PRISMM trial which allows you to receive immunotherapy at your local cancer clinic without ever having to travel! https://clinicaltrials.gov/ct2/show/NCT04447651
Dee0
