Topic: Sacituzumab Govitecan (Trodelvy)

Jan 28, 2021 07:58AM DoubleBloom wrote:

It's nice to hear from you, Libby. Good to know that nothing is growing... now I pray for you that things start shrinking. Glad to know your side effects are in control. It must give you at least some relief.

Jan 28, 2021 08:35AM DoubleBloom wrote:

HUGE CONGRATULATIONS Sharon!! That is something beyond special to look forward to. I'm very happy for you.

Feb 13, 2021 09:26PM - edited Feb 13, 2021 09:27PM by NorCalS

Texaslaughter,

Thanks for checking in and sharing your good news. It's very helpful to know that Trodelvy is effective.

Anornurse, congrats to you and your family. Great news

Feb 16, 2021 01:12PM - edited Feb 16, 2021 01:14PM by moth

sac321, I've only seen it recommended for TNBC. My copy NCCN guidelines lists it for tnbc. Keytruda (another immunotherapy) recently got FDA approval for ER+ tumors with high tumor mutation burden &/or microsatellite instability (established by genomic tests such as Foundation One) but I've not seen trodelvy recommended for that. Maybe I missed something ... hope someone else wades in with evidence for this

ETA: link to FDA running updates on approved cancer treatments. Trodelvy is only listed for TNBC in April 2020. So I think this would be offlabel use?

https://www.fda.gov/drugs/resources-information-ap...

Mar 10, 2021 10:54AM Wanderingneedle wrote:

Unfortunately I may be moving off of Trodelvy. ☹️ My skin mets have returned - they are small bumps under my arm. I will have a scan in two weeks but in the meantime we’re returning my dosage to full strength for this cycle to see if it makes a difference since the skin mets almost completely disappeared after just the first cycle. After 3 cycles at full strength it was reduced because of side effects and that’s when the cancer stopped shrinking and stayed the same size. I just had a scan in January and showed nothing was growing or shrinking so I guess the cancer is pushing back now. My doctor ordered the blood test for circulating tumor cells dna and she has my last biopsy results and she clinical trials beginning soon and she researched TNBC. Almost all of her patients are metastatic. I’m in good hands. As much as I don’t like the side effects I’d like to get some more time out of this treatment before moving on because none of them seem to last long.

I hope everyone else is doing well! Spring is coming and so much to look forward to! 🌸🌼🌷🌱

Mar 10, 2021 06:32PM Wanderingneedle wrote:

Thanks, moth,

She didn’t mention radiation or surgery. I had radiation there last year and these showed up about halfway through and I thought it was possibly from the radiation. Because of COVID my oncologist at the time was only doing online appointments even after he knew about the new skin mets (he never saw me). He offered me gemzar as a single agent and went to a second opinion about that treatment and I stayed. My current oncologist is looking for mutations and the scan will tell us if everything else is also growing. My first two oncologists would not be so proactive - just throw something else out there and see if it works.I asked to go back to the full dose to see if it would work because I hate to just give up. I’m so heavily pretreated now I hate to get rid of anything that’s working. It’s just the side effects that are hard.

Mar 26, 2021 09:31AM thrivingmama wrote:

Hi. I am adding a bit more detail to my question, in case anyone has thoughts :). I also posted on the liver mets and enhertu threads.

I am wondering if anyone has been on Trodelvy at a lower dose and then increased it with success? Also, does anyone have experience with both Trodelvy and Enhertu?

I was on Trodelvy June 2020-Jan 2021. I was on a 50% dose the entire time, and I had a really spectacular response, but unfortunately had progression in January. We debated going up in dose, but decided instead to try Abraxane. While I had one of the larger liver tumors respond to Abraxane, the rest have increased in size and activity, so I need to move on. I am again thinking about going back to Trodelvy, but at a higher dose. I am also looking into access to Enhertu. So, curious if anyone has any experience or words of wisdom.

I am heavily pre-treated and the Phase I trial world seems quiet right now....

Thanks for any thoughts :)

Mar 26, 2021 10:14PM thrivingmama wrote:

Thank you for the tip! I've actually seen Dr. Shatsky and could probably reach out to her through myChart too. I'll check out her twitter. Thanks!

Mar 29, 2021 05:34AM anornurse wrote:

Texaslaughter, Way to go! We are all rooting for you! Sharon

Apr 13, 2021 09:49AM DoubleBloom wrote:

I was on Trodelvy from Sept to Dec 2020. My treatment was every other week and I also had intrathecal topotecan every month.

In Dec, my brain and spine were clear of any tumors so my doctor said I could come off all the chemo and take a break from all the side effects. Unfortunately my most recent MRIs in March showed three new tumors in the brain. I had gamma knife radiation last week and will go back on Trodelvy starting this Friday.

How long have some of you been on Trodelvy without a break and what are your worst side effects.

Thanks in advance.

Apr 14, 2021 01:45AM anornurse wrote:

Hello, I have been on trodelvy since 5/20. when it first came out. I am taking a break from 3/21 til present. I have tnbc, brain, spine and both lungs. I received the cyber knife for both lungs which is working well. I believe in trodelvy very much. Please read Gilead Science's press release from 7/7/21. It has received full FDA approval. I think you will believe as well. Sharon

Apr 14, 2021 05:59AM DoubleBloom wrote:

S3K5... It's nice to have you in the group. I didn't need steroids while on Trodelvy though the nurses gave me one pill as a part of my premeds. I did develop a severe rash and became neutropenic which required a 5 day hospital stay. After that I took Zarxio injections to keep my blood counts up. I had a week of constipation followed by a week of diarrhea. Fatigue was always an issue.

Anornurse... Thanks to mentioning Gilead's press release. Congrats for getting off the Trodelvy. Your good response is encouraging.

Apr 15, 2021 11:05AM DoubleBloom wrote:

S3K5...I was on Trodelvy for four months from last Sept to Dec. Tough side effects plus negative scans made my MO advise a break from all chemo. I think he was very surprised to see the tumors come back so quickly. The skin rash only happened once, after my 2nd infusion, and I was admitted to the hospital. Because my WBC was only 0.04 I could not be put on steroids at that time since steroids can increase the risk of serious infection. I was placed on all sorts of antibiotics and discharged when my blood counts improved. I only receive dexamethasone as one of my premeds on the day of infusion. I start back on Trodelvy and intrathecal topotecan tomorrow. My doc doesn't think the rash will recur.

Let me know if you have any other questions.

Apr 15, 2021 11:30AM anornurse wrote:

I received cyber knife to my brain and both lungs and get monitored by a cat scan of my chest and an MRI of my brain. I have been off the trodelvy since 3/21. That’s my story and I’m sticking to it, lol! Sharon

Apr 20, 2021 05:33PM Grannax2 wrote:

I’m new to this thread. Just trying to educate myself in case I need Trodelvy in the near future. I have a long, complicated history of BC and MBC. Yes, I’m heavily pre treated, etc. My MO said after so many different chemos, Ibecome resistant and my odds are low for my cancer to respond

At this point, I have diffuse liver mets and very few choices left for chemo. I’ve been on BCO since 2017. I’ve exhausted all options for local TX to liver. I also have lung mets. It’s a long story.

I’m on Navelbine right now. I just started it after Eribulin failed. I post mostly on the liver mets thread.

So, I’m curious to hear about your experiences on Trodelvy. 💞