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All TopicsForum: Stage IV and Metastatic Breast Cancer ONLY → Topic: Ibrance (Palbociclib)

Topic: Ibrance (Palbociclib)

Forum: Stage IV and Metastatic Breast Cancer ONLY —

A place for those managing the ups & downs of a Stage IV/metastatic breast cancer diagnosis. Please respect that this forum is for Stage IV members only. There is a separate forum For Family and Caregivers of People with a STAGE IV Diagnosis.

Posted on: Feb 25, 2015 11:21AM - edited Dec 12, 2017 04:43AM by Moderators

Romansma wrote:

A bottle of Ibrance came in the mail today. I will start taking it tonight with Femara. Hoping that others starting on this drug will join me here to talk about side effects and how to avoid or treat them. So far, I've been warned about low white counts. I run very low as it is, probably because of my extensive bone mets. Anyone currently on Ibrance?

Edited by Mods to add Mod Note: Unfortunately, Romansma passed away in 2016. Our thoughts are with all who loved Hope.

Edited by Mods to add:

For more information on this medication, see the main Breastcancer.org site's section on Ibrance for information on how it works, who it's for, what to expect, and side effects. Also, read the latest research on the Research News on Ibrance pages.

Pfizer Oncology Together is a first-of-its-kind program for patients taking Pfizer Oncology medicines that offers dedicated social workers called 'Care Champions' to help navigate the complexities that accompany treatment, such as identifying resources to help find emotional support, and workplace transition, transportation and financial assistance.

For cancer patients taking a Pfizer Oncology medicine (e.g. Ibrance) or caregivers, please visit www.PfizerOncologyTogether.com.

For live support call: 1-877-744-5675

Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Feb 13, 2018 12:11PM PatgMc wrote:

Iwrite, you are my role model! If my scans look good after 6 months at 75mg, I plan to suggest to my oncologist that I do your two weeks on, two weeks off protocol. We have discussed how subjective things are with these new drugs and agree that we will adjust to achieve the greatest quality of life. I'm all for a longer life if that is to be but I'm more about enjoying the time I'm here! It would be fun to stay around for that 25mg dose though!

Pat G. Dx 2/1994, IDC, Left, 4cm, Stage IIB, Grade 3, 0/15 nodes, ER-/PR- Dx 3/2002, IDC, Right, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2+ (FISH) Dx 3/2012, Right, 1cm, ER+/PR+, HER2- Dx 9/2016, IDC, 0/16 nodes, ER+/PR+, HER2- Targeted Therapy 10/1/2016 Ibrance (palbociclib) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap Chemotherapy FAC Chemotherapy Carboplatin (Paraplatin), Taxol (paclitaxel) Surgery Lymph node removal; Mastectomy; Reconstruction (right): Tissue expander placement
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Feb 13, 2018 01:54PM Jaylea wrote:

JunieB, ouchie is right. I hope you're getting some pain relief. I haven't read anything about bone breaks on this protocol, but many women are on bone strengthening treatment like Zometa for bone mets. Hopefully someone can chime in here soon.

CloudNine, welcome to our band of sisters.

Midwest Laura, I echo what others said about preferring to stay ahead of progressing to the extent I can. I had a scare on an early scan with a very small spot on my liver. My MO said it was too small to cause any SE's. Follow up scan showed stable, so I'm going with fatty tissue. But what if it was cancer? I'd hate to think how far it would have to go to tell me it had arrived.

cchilders, congrats on your retirement. You sound at peace with your decision. I was self-employed and loved my job, but retiring and going on SSDI was the best thing for my health and family. Should something happen to me, my DH is eligible at age 60 to get something like 70% of my benefit.

Hope everyone finds moments of joy every day.

Dx 10/2006, IDC, Left, Stage IIB, ER+, HER2- Dx 5/2017, IDC, Stage IV, metastasized to bone/lungs, ER+, HER2- Hormonal Therapy 6/20/2017 Femara (letrozole) Targeted Therapy 7/26/2017 Ibrance (palbociclib)
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Feb 13, 2018 04:01PM faheem0 wrote:

Hi Chicagoan,

Thank you very much for your reply, but I didn't get a notification of it, either on the site or by email. Did you reply to me? In general, is there any way to track replies to me? Sorry if this is obvious, but I'm not familiar with this forum.

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Feb 13, 2018 04:29PM Liwi wrote:

Candy I started with 125/mg and counts dropped to low. Next moved to 100 mg and still had low count issues requiring longer breaks. My MO then changed me to stay with 100 mg but for 18 days on and 10 days off which has worked with my blood counts though I still get fatigue. She prefers that to moving me to a 75 mg dose for 21 days. My tumors shrank after my 3 month scan. I’ll scan again in late March and hope it will show this is still working for me.

It’s interesting to see the different approaches.

Dx 9/2014, ILC, Left, 4cm, Stage IIB, Grade 2, ER+/PR+, HER2- Chemotherapy 10/23/2014 AC + T (Taxol) Dx 4/2015, ILC, Left, 6cm+, Stage IIIA, Grade 2, 3/3 nodes, ER+/PR+, HER2- Surgery 4/2/2015 Lumpectomy: Left; Lymph node removal: Sentinel Hormonal Therapy 4/20/2015 Arimidex (anastrozole) Radiation Therapy 5/6/2015 Dx 7/2017, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Hormonal Therapy 8/10/2017 Faslodex (fulvestrant) Targeted Therapy 8/10/2017 Ibrance (palbociclib)
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Feb 13, 2018 05:17PM GracieM2007 wrote:

I’ve been having what I think may be tumor flare. Spent all weekend on Norco due to pain in my neck and shoulder, I have an appt tomorrow with my oncologist, don’t know whether to say anything or just wait until three month scans in another month

dx 4/11/2007, rt. mast 4/27/2007, 1.7cm IDC, stage 2, Grade 3, 1.4cm tumor in one node,, ER/PR+, Her2-, 4 DD AC, 4 DD T, Arimidex/ 2016 mets to bone, extensive. Femera, Xgeva.
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Feb 13, 2018 10:42PM JoynerL wrote:

Gracie, I'm a believer in always saying something to your onc if you have a concern.

Dx 12/1990, IDC, Left, <1cm, Stage IIA, ER+ Hormonal Therapy 6/30/1991 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 10/31/2002 Evista (raloxifene) Dx 2/9/2017, IDC, Left, 1cm, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Ibrance (palbociclib)
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Feb 14, 2018 12:51AM Iwrite wrote:

Gracie, Hope you can get the pain under control! If there is a chance your MO can help it's worth a call

Kathryn Dx 11/2/2015, ILC, Both breasts, 6cm+, Stage IV, metastasized to bone, ER+/PR+, HER2- Hormonal Therapy 11/6/2015 Femara (letrozole) Targeted Therapy 11/12/2015 Ibrance (palbociclib)
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Feb 14, 2018 02:00AM Chicagoan wrote:

Faheem,

I sent you a private message just now. We do not get notified of replies to posts on threads so we just have to keep checking to see if anyone responded. We do get notified of private messages. Peace to you and your mother.

Dx 9/21/2016, IDC, Left, Stage IV, metastasized to bone/liver, Grade 1, ER+/PR+, HER2- Radiation Therapy 9/26/2016 Hormonal Therapy 10/5/2016 Femara (letrozole) Targeted Therapy 10/26/2016 Ibrance (palbociclib)
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Feb 14, 2018 10:09AM Moissy wrote:

If you would like to be notified of replies on a particular thread, look for the heart at top or bottom of the thread and click on "Add to my Favorite Topics." Then click on the blue navigation bar that says, "My Favorite Topics." You will have the option there to "Add email notification." You'll then be emailed every time a new post appears on that thread. You can change this option if you decide later that you no longer want it. Hope this helps.

Dx 2004, IDC, 6cm+, Grade 2, 0/1 nodes, ER+, HER2- Dx 2015, Stage IV, ER+/PR+, HER2-
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Feb 14, 2018 11:01AM janky wrote:

Hi everyone, I am another 'newbie' - and yes, I would rather not be, so be it, I am grateful for this site! I have been reading the posts for the last few days and thought I would jump in with this question, is there a place (preferably on this site) that explains some of the abbreviations and terms? I have determined that MO is Medical Oncologist, bone mets is metastatic, etc., Is there such a place here so that I don't have to 'guess' the terms? If not, that is okay I am truly learning from your posts and appreciate how difficult it can be to share our journeys. I am on Day 12 of my first 21 day cycle of Ibrance 125 with Letrozole - so far so good....

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Feb 14, 2018 11:03AM Bigbhome wrote:

Hi all, I see several newbies. You are in good hands here!

I have been feeling really terrible all winter. Lots of gastric issues, greater than ever fatigue and tons of stomach pain, while fighting two viruses back to back. We are also having a tough time right now. Too much to go into here. I am on cycle 27.

I have decided that I am taking a break from Ibrance and possibly from Letrozole. I have 3 more days and then I am stopping until... I meet the Mo on March 6, he is not going to be happy with me but I need a break. My whites and reds need to get back to normal for awhile. I need to have some energy, I need to enjoy my life for awhile! I'm thinking one to three months off. Scans in April, then I can rethink everything.

Good luck to everyone here! I hope that each of you get a long time on this drug.

Hugs and prayers

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Feb 14, 2018 11:28AM - edited Feb 14, 2018 11:31AM by PatgMc

BigbHome, I'm so sorry you're having a hard time. I'm glad you've decided to take a break and I don't think you'll regret it. I had promised myself a break anyway but then got the flu/pneumonia which made it a bit longer. I took around 2 months and then went down from 100mg Ibrance to 75mg. I'm so thankful for the good month I've had on that and I look forward to hearing about the nice changes you see. I'll be praying for you.

Pat G. Dx 2/1994, IDC, Left, 4cm, Stage IIB, Grade 3, 0/15 nodes, ER-/PR- Dx 3/2002, IDC, Right, <1cm, Stage IA, Grade 1, 0/3 nodes, ER+/PR+, HER2+ (FISH) Dx 3/2012, Right, 1cm, ER+/PR+, HER2- Dx 9/2016, IDC, 0/16 nodes, ER+/PR+, HER2- Targeted Therapy 10/1/2016 Ibrance (palbociclib) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap Chemotherapy FAC Chemotherapy Carboplatin (Paraplatin), Taxol (paclitaxel) Surgery Lymph node removal; Mastectomy; Reconstruction (right): Tissue expander placement
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Feb 14, 2018 11:29AM IntoLight wrote:

Hi Janky. Welcome to our little group. If you will scroll below all of the dark blue bars at the top (All Topics, Active Topics, etc.) you will find a separated blue bar that says "Help with Abbreviations". Click on that and that should help you. I am glad you are doing well so far. Some of us are able to stay with 125 but others are not. Whatever happens, I hope you find the help you need.




Shining the light of God's grace to the world. Dx 5/20/2016, Left, 3cm, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole)
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Feb 14, 2018 11:38AM janky wrote:

Thank you - just what I was looking for...I will keep you posted and just being able to read/share these posts is great therapy'!

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Feb 14, 2018 01:36PM CloudNine wrote:

Hi Janky - sounds like we're starting down the Ibrance road together at the same time. I'm also on Ibrance 125 mg with letrozole and so far I haven't had any major issues either these first few weeks. Had my first bone builder infusion of Zometa today and no pain or reaction yet. Thanks everyone on your advice to take Claritin - I think it helped a lot, even though my onc nurse had never heard of it before.

Dx 1/7/18 de novo stage IV w/bone mets on spine and skull. ER+PR+Her2- Grade 2. Hormone Therapy 2/2/18 - Femara. Targeted therapy -2/10/18 - Ibrance. Zometa - 2/13/18.
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Feb 15, 2018 01:34AM CloudNine wrote:

Zometa kicking my butt today. Every bone aches, chills, dizziness, nausea, headache. Guess the Claritin didn't work for me after all - bummed. Supposed to be 40 today - birds are happy. Happy Valentines Day to all of you. Hope someone's love blessed your day

Dx 1/7/18 de novo stage IV w/bone mets on spine and skull. ER+PR+Her2- Grade 2. Hormone Therapy 2/2/18 - Femara. Targeted therapy -2/10/18 - Ibrance. Zometa - 2/13/18.
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Feb 15, 2018 01:54AM GracieM2007 wrote:

I saw my oncologist yesterday got the results of my blood work up. All of my blood counts are down, and my tumor markers continue to rise. I’m on my second round of Ibrance. The oncologist is concerned, so I’ll have a MRI and two weeks and then a CAT scan and a bone scan. He said my pain should not be increasing that should be going down by now, that and the increasing tumor markers has him concerned. I’m just really scared that Ibrance is not working. He did reassure me that I Brandts works very slowly and I already knew that but that with the new extreme pain in my neck has him very concerned. So I guess we’ll see. I’m really bummed out, I was really hoping this would be my drug that would give me 34 years. Femara only lasted a year. I was hoping for three years from it but no such luck. Will let you all know when I figure something out

dx 4/11/2007, rt. mast 4/27/2007, 1.7cm IDC, stage 2, Grade 3, 1.4cm tumor in one node,, ER/PR+, Her2-, 4 DD AC, 4 DD T, Arimidex/ 2016 mets to bone, extensive. Femera, Xgeva.
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Feb 15, 2018 04:30AM IntoLight wrote:

Gracie, I am so sorry to read that you are struggling on Ibrance. I will pray it is only a flare as the Ibrance is working (happens sometimes) and that your scans will look better.

CloudNine, I am also sorry you are struggling on Zometa. My first one was rough also, but the rest have been much better. Stay well hydrated.


Shining the light of God's grace to the world. Dx 5/20/2016, Left, 3cm, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole)
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Feb 15, 2018 07:48AM Jaylea wrote:

Gracie, don't give up hope on the Ibrance just yet. My first couple of months were hard, all kinds of weird pains in met- and non-met sites. My first scan showed irregular activity and I was convinced it was failing me. But in month 3 things settled down and my next scan was stable. Looking back, the pain was likely from healing. My TM's were never reliable so I don't test them, but I've heard from others that healing activity can cause them to rise, too. I was just on another thread where the topic was how the cold weather affects bone mets. Sending prayers your way.

Janky, welcome. You'll get great advice and support here on just about any topic.

Bigbhome, at cycle 27, yes, dear one, take a break. Let your body rest and your counts recover. Hugs to you.

Hoping everyone enjoys a little indulgence and some 'me' time this Valentines Day.

Dx 10/2006, IDC, Left, Stage IIB, ER+, HER2- Dx 5/2017, IDC, Stage IV, metastasized to bone/lungs, ER+, HER2- Hormonal Therapy 6/20/2017 Femara (letrozole) Targeted Therapy 7/26/2017 Ibrance (palbociclib)
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Feb 15, 2018 08:01AM janky wrote:

Jaylea - where is the thread on cold weather and bone mets? I live in Alberta and it has been sooooo cold :) ...My hubby (43 years married in March) and I are going out for a surf and turf meal for Valentine's - I too wish everyone indulgence and 'me' time today and always. One of these days I will get out my diagnosis/treatment stuff and put it in my profile, thanks for such a great, supportive site.

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Feb 15, 2018 08:26AM - edited Feb 15, 2018 08:28AM by Blueshine

Gracie, your neckpain reminded me on mine earlier this year. It was so severe that I couldn't ride in the car and driving was impossible. What helped me was professional massage. The MRI should show where is the problem. I just did my first PET scan after almost 3 cycles on I/F. No SE so far

Dx 9/2011, IDC, Right, 2cm, Stage IIB, Grade 2, 1/18 nodes, ER+/PR-, HER2- Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole) Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Arimidex (anastrozole) Surgery Lymph node removal: Sentinel, Underarm/Axillary; Mastectomy: Right
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Feb 15, 2018 08:27AM NettaGER wrote:

janky: I asked the question in the Bone Mets thread, because we are currently having a cold weather period in Germany and since about then I also experience increased bone pain. I hurt all over and feel like an old woman. My physiotherapist said that there might be a correlation. It appears that other bone met sisters also experience the same issue.

Dx 8/31/2017, IDC, Right, 6cm+, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2- (FISH) Hormonal Therapy 9/15/2017 Femara (letrozole), Zoladex (goserelin) Targeted Therapy 9/15/2017 Ibrance (palbociclib)
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Feb 15, 2018 08:41AM - edited Feb 15, 2018 08:41AM by Blueshine

Hi to all newbies! Sorry that you are here, but this group will support you in any way. You ll see that you are not alone . This tread was a lifesaver for me and I learned more than I could imagine.

Prayers and hugs to all of you

Dx 9/2011, IDC, Right, 2cm, Stage IIB, Grade 2, 1/18 nodes, ER+/PR-, HER2- Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole) Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Arimidex (anastrozole) Surgery Lymph node removal: Sentinel, Underarm/Axillary; Mastectomy: Right
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Feb 15, 2018 12:24PM Midwest_Laura wrote:

I received all of the details from my 2nd opinion.  Basically ... stay the course.  I guess that's good.  All of the scanning this past weekend found a previously unknown met in my femur.  The new MO thinks that it has been there the whole time, but my minimalistic scanning never showed it.  So, the current plan is to sit tight and keep going with the 125 mg of Ibrance.  Regarding my fatigue - the new MO thinks that my exceedingly poor sleep may be the culprit.  I wake throughout the night with hot flashes and then can't get back to sleep.  So, we'll try resolving the hot flashes first before considering a lower dose.  This seems counter to what so many of you have reported here with regards to feeling better on 100 or 75 mg.  I'm willing to give it a try for another month or two.  If I don't see any positive effects on the hotflashes, I'm going to ask for a change.  Lower Dose  = QOL ??

Oh, and regarding those tumor markers that have never been tested before... my aren't too high, are they?  I know, a number doesn't mean anything until you compare it to something else.  It's the trends that matter, right?  But, still....

CA 15-3 = 27
CA 27.29 = 27.0
CEA = 4.5

One final note - just wanting to brag a bit - my Abs. Neutrophils were at 2.14.  Yup.  That's right.  A whopping 2.14.  They haven't been this high since before big-guns chemo back in 2016.  Can I get a WooHoo!?!?! 


Dx 11/25/2016, IDC, Right, 6cm+, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2- Chemotherapy 12/21/2016 AC + T (Taxol) Hormonal Therapy 5/2/2017 Femara (letrozole) Targeted Therapy 5/27/2017 Ibrance (palbociclib) Surgery 7/13/2017 Prophylactic ovary removal
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Feb 15, 2018 12:49PM IntoLight wrote:

Midwest_Laura, good job on the markers, although sometimes they fluctuate and some oncs do not pay attention to them too much. Your blood levels, though, are great. Take a big breath, and relax. Give the Ibrance some time to work and your body time to get used to it. I am on cycle 21 of 125 mg and actually feel pretty fair most days, but it has taken me time. Don't jump ship too early.

Shining the light of God's grace to the world. Dx 5/20/2016, Left, 3cm, Stage IV, metastasized to bone/liver, ER+/PR+, HER2- Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole)
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Feb 15, 2018 01:02PM janky wrote:

Whoot! Whoot! Yayyy!

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Feb 15, 2018 01:23PM Midwest_Laura wrote:

IntoLight: 21 cycles at 125?  Wow!  You've given me a new target.  If you can do it, then I can too.  Just need to breath and relax.

Dx 11/25/2016, IDC, Right, 6cm+, Stage IV, metastasized to bone, Grade 2, ER+/PR+, HER2- Chemotherapy 12/21/2016 AC + T (Taxol) Hormonal Therapy 5/2/2017 Femara (letrozole) Targeted Therapy 5/27/2017 Ibrance (palbociclib) Surgery 7/13/2017 Prophylactic ovary removal
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Feb 15, 2018 02:54PM GracieM2007 wrote:

I’m probably just feeling the fear that this may last way less time than the Femera. And tonight my mouth hurts...badly! I have a sore spot on the roof of my mouth and the back of my tongue! Geesh..if it’s not one thing it’s another

dx 4/11/2007, rt. mast 4/27/2007, 1.7cm IDC, stage 2, Grade 3, 1.4cm tumor in one node,, ER/PR+, Her2-, 4 DD AC, 4 DD T, Arimidex/ 2016 mets to bone, extensive. Femera, Xgeva.
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Feb 15, 2018 08:13PM JoynerL wrote:

Midwest, YAHOO on the markers!! Gracie, I've never had the mouth sores, but there are lots of suggestions on this string for help with that. I recall that Patgmc uses a particular yogurt to great success. Just do a search; I think that you can find specific posts that way.

Dx 12/1990, IDC, Left, <1cm, Stage IIA, ER+ Hormonal Therapy 6/30/1991 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 10/31/2002 Evista (raloxifene) Dx 2/9/2017, IDC, Left, 1cm, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Ibrance (palbociclib)
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Feb 16, 2018 12:20AM Frenchhorn654 wrote:

Got results of my pet scan yesterday, no new mets, disease is stable, and since starting ibrance TM has quit rising and leveled off, onc is saying stay the course but since I've been feeling so sick on the 125 to bump it back down to 100. I feel relief and hope that I have can settle into this treatment for a long time!

Dx 6/2006, Right, 2cm, Stage IIB, 3/13 nodes, ER+/PR+, HER2- Dx 6/2011, Right, Stage IV, metastasized to lungs Dx 5/2017, Stage IV, metastasized to lungs Hormonal Therapy 10/9/2017 Faslodex (fulvestrant) Surgery Hormonal Therapy Aromasin (exemestane), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy Whole-breast Chemotherapy AC Surgery Lymph node removal: Right; Mastectomy: Right

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