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Topic: Ibrance (Palbociclib)

Forum: Stage IV/Metastatic Breast Cancer ONLY —

Please respect that this forum is for members with stage IV/metastatic breast cancer only. There is a separate forum for caregivers and friends: Caring for Someone with Stage 4 or Mets.

Metastatic breast cancer (MBC; also called stage IV) is breast cancer that has spread to other parts of the body, most commonly the bones, liver, brain, or lungs. Metastatic breast cancer can be treated but not cured. Metastatic disease is NOT hopeless. There are a wide variety of treatment options for metastatic breast cancer, and new medicines are being tested every day. More and more people are living life to the fullest while being treated for metastatic breast cancer.

Note: Please contact your doctor for any specific concerns about symptoms you are experiencing or your course of treatment.

Learn more about living with MBC.

Intro medically reviewed by: Brian Wojciechowski, M.D.
Last review date: November 22, 2020

Posted on: Feb 24, 2015 02:21PM - edited Dec 11, 2017 07:43AM by Moderators

Romansma wrote:

A bottle of Ibrance came in the mail today. I will start taking it tonight with Femara. Hoping that others starting on this drug will join me here to talk about side effects and how to avoid or treat them. So far, I've been warned about low white counts. I run very low as it is, probably because of my extensive bone mets. Anyone currently on Ibrance?

Edited by Mods to add Mod Note: Unfortunately, Romansma passed away in 2016. Our thoughts are with all who loved Hope.

Edited by Mods to add:

For more information on this medication, see the main Breastcancer.org site's section on Ibrance for information on how it works, who it's for, what to expect, and side effects. Also, read the latest research on the Research News on Ibrance pages.

Pfizer Oncology Together is a first-of-its-kind program for patients taking Pfizer Oncology medicines that offers dedicated social workers called 'Care Champions' to help navigate the complexities that accompany treatment, such as identifying resources to help find emotional support, and workplace transition, transportation and financial assistance.

For cancer patients taking a Pfizer Oncology medicine (e.g. Ibrance) or caregivers, please visit www.PfizerOncologyTogether.com.

For live support call: 1-877-744-5675

Hope Dx 10/22/2010, ILC, Right, 6cm+, Stage IIIB, Grade 2, 9/10 nodes, ER+/PR+, HER2- (FISH) Chemotherapy 11/1/2010 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Taxotere (docetaxel) Chemotherapy 4/1/2011 Abraxane (albumin-bound or nab-paclitaxel), Cytoxan (cyclophosphamide) Radiation Therapy 6/8/2011 Whole-breast: Breast, Lymph nodes, Chest wall Surgery 11/29/2011 Prophylactic ovary removal Dx 8/2013, ILC, Stage IV, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 9/17/2013 Faslodex (fulvestrant) Targeted Therapy 1/25/2014 Afinitor (everolimus) Radiation Therapy 2/11/2014 External: Bone Chemotherapy 12/6/2014 Xeloda (capecitabine) Hormonal Therapy 2/20/2015 Femara (letrozole) Targeted Therapy 2/20/2015 Ibrance (palbociclib)
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Jan 9, 2021 09:07AM aprilgirl1 wrote:

BevJen - let us know how it goes and I am sending you all the best for the Keytruda treatment.

Jaycee - that is chilling AND my docs don't seem to communicate with each other, either .

Katrose - in your pocket for 1/20 scan!

RRabbit - hope your appt and zometa infusion were both painless and good.

Update on my petscan yesterday. I asked my "team" to call me with any results - petscan was at 9am (check in at 7am ). I got the call at 4:59pm from a nurse that the preliminary report was no uptake in FDG noted. She was reading notes to me and I am pretty sure she said "No evidence of active disease" but also said this is preliminary and my oncologist will review it at our appt on Monday. Of course, the report is "locked" and won't be in my online medical chart until after my oncologist meeting but I am relieved and so very thankful for Ibrance, Fulvestrant and science. I had my first NEAD pet in June, same in September and looks like i have NEAD still.

Sending you all good vibes for a great weekend!

recurrence in lymph nodes (superclavicle/mediastinal)"You can do it like it's a great weight on you, or you can do it like it's part of the dance." Ram Dass Dx 11/7/2008, IDC, Left, 1cm, Stage IB, Grade 2, 0/3 nodes, ER+/PR+, HER2- Dx 11/13/2019, IDC, Left, Stage IV, metastasized to other, ER+/PR+, HER2-
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Jan 9, 2021 09:15AM candy-678 wrote:

Aprilgirl- Sounding good!!!! Of course, you need to hear final report from MO, but WOOHOO.

Where is RK2020????? She had MO appt before Christmas and no word. Unless I missed it.

Found mets on CT for unrelated issue. I only had 2 treatments with IV chemo for the Stage II, then found Stage 4 and switched to hormone therapy/targeted therapy. I consider myself de novo. Also using Xgeva injections for bone mets Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole), Zoladex (goserelin) Chemotherapy AC Surgery Lymph node removal: Sentinel; Mastectomy: Left
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Jan 9, 2021 02:31PM RhosgobelRabbit wrote:

aprilgirl, wooooo!! So happy for you. Day after the Zometa, feel like I got hit by a truck but I'll be better tomorrow, usually takes a day or 2 afterwards to bounce back.

Where is RK, Ciaci, Philly, etc? Checkin ladies if you can, your missed :)

Mets @ Rads planning. Mets to Pelvis, Femurs, Shoulders, Ribs, T. Spine, L. Spine, Sternum, Sacrum/SI Joints. MyRisk neg. KEAP1 "Courage of the heart is very rare, there's a power when its there" 37yrs old @ IV DX. lifeandirises.home.blog/ Dx 7/30/2018, IDC, Right, 4cm, Stage IIB, Grade 2, ER+/PR+, HER2- Chemotherapy 9/27/2018 AC + T (Taxol) Hormonal Therapy 9/27/2018 Zoladex (goserelin) Dx 4/19/2019, IDC, Right, 3cm, Stage IIB, Grade 2, 5/16 nodes, ER+/PR+, HER2- (IHC) Surgery 4/19/2019 Lymph node removal: Right, Sentinel, Underarm/Axillary; Mastectomy: Right Hormonal Therapy 5/14/2019 Zoladex (goserelin) Dx 5/17/2019, IDC, Right, Stage IV, metastasized to bone, ER+/PR+, HER2- (IHC) Surgery 10/2/2019 Prophylactic ovary removal Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Aromasin (exemestane)
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Jan 11, 2021 08:51AM snooky1954 wrote:

Bev Jen all the best on your new treatment plan. I am one of those rare girls that A/A works on. Shrinkage in first 3 months. But it's dropped my hemo to 10. Neve been under 11.5 in over 3 years. Only other side effect is extreme muscle aches, heating pad helps alot. The reason I'm telling you all about my treatment is cause there isn't a soul on A/A page

Dx 7/2017, IDC, Right, 4cm, Stage IIB, Grade 2, ER+/PR+, HER2- (FISH) Dx 8/2018, IDC, Right, Stage IV, metastasized to lungs Targeted Therapy 8/14/2018 Ibrance (palbociclib) Dx 11/1/2018, IDC, Right, Stage IV, metastasized to bone/lungs Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Arimidex (anastrozole) Chemotherapy Xeloda (capecitabine) Chemotherapy Taxol (paclitaxel) Radiation Therapy Bone
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Jan 11, 2021 10:14AM Nkb wrote:

Snooky- I am glad it is still working for you. so far my easiest therapy-

Cheers!!

Dx 1/2012, ILC, Stage IIIC, Grade 2, ER+/PR+, HER2- Surgery 2/4/2012 Lymph node removal: Left, Right, Underarm/Axillary; Mastectomy: Left, Right Chemotherapy 2/28/2012 AC + T (Taxol) Radiation Therapy 9/11/2012 Hormonal Therapy 10/21/2012 Arimidex (anastrozole) Dx 5/2017, Stage IV, metastasized to bone/other, ER+/PR-, HER2- Hormonal Therapy 6/1/2017 Faslodex (fulvestrant) Targeted Therapy 6/1/2017 Ibrance (palbociclib) Targeted Therapy 3/13/2019 Afinitor (everolimus) Hormonal Therapy 3/13/2019 Aromasin (exemestane) Chemotherapy 3/10/2020 Xeloda (capecitabine)
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Jan 11, 2021 07:03PM annadou wrote:

Hi All

Hope you are all ok

Any info on what to expect with Ibrance and Falsodex would be extremely welcome good or not so good
I will be starting these within a few days and I wonder if taking at night or morning is better just some things you have experienced and how you dealt with them

I really am dreading this bunch of meds

Keep well

Ann

Dx 3/13/2009, IDC, Left, <1cm, Stage IIB, Grade 2, 4/21 nodes, ER+/PR+, HER2- (SPOT)
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Jan 11, 2021 07:29PM Cure-ious wrote:

Hi Ann,

These drugs are excellent, you might need to eventually reduce the dose of Ibrance due to low neutrophils, but in the beginning expect a lot of fatigue that will dissipate quite a bit as your body adjusts. Are your mets only in the mediastinal node? In this case radiation could be really effective also..

Dx 10/2003, IDC, Stage IIB, ER+/PR+, HER2- Dx 7/2015, Stage IV, metastasized to bone, ER+/PR-, HER2-
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Jan 12, 2021 01:25AM annadou wrote:

Thankyou for the iinfo.

As far as I know it’s only in the mediastinal nodes but things get lost in translation . My report is in Greek but that’s what it appears to be. I am fairly confident that everything possible is being done because we have good doctors here but not so good nursing

He mentioned radiation but it’s too near the heart and big vessels for now- will see how it goes as he said ...

Drugs have been approved do now have to psych myself up to this fuckfest. Sorry if I offend

Warm hugs

Anna

Dx 3/13/2009, IDC, Left, <1cm, Stage IIB, Grade 2, 4/21 nodes, ER+/PR+, HER2- (SPOT)
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Jan 12, 2021 01:40AM BevJen wrote:

Annadou,

You should review as much of this thread as you can -- especially look at the beginning -- there are a lot of tips here from people who have bee on these drugs. They are very powerful and good for most people. For me (I've been on Ibrance and faslodex for about 18 months) the most common side effects I've had are fatigue (no predictability on that), stuffiness like a head cold some of the time, some bloody discharge some months from my nose, some nausea (again, no rhyme or reason to when) and some appetite changes. These are all manageable.

Good luck to you.

Microwave Ablations of the Liver: 7/2019; 10/2020; 12/2020 Dx 11/2003, ILC, Left, Stage IIIC, 13/18 nodes, ER+/PR+, HER2- Dx 6/2006, ILC, Stage IV, metastasized to other, ER+, HER2- Dx 5/2019, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Surgery 7/4/2019 Targeted Therapy 7/31/2019 Ibrance (palbociclib) Immunotherapy Radiation Therapy Surgery Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Chemotherapy TAC Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Hormonal Therapy Femara (letrozole)
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Jan 12, 2021 02:17AM Simone80 wrote:

Hi Ann,

I used to get bad mouth sores. There is a mouthwash you can get a prescription for which will help with those. Those will diminish as your body gets use to the meds. It's been 2 years on I\F for me now and the only SE that I have now is fatigue.


Dx 7/2001, IDC, Right, 1cm, Stage IIIA, Grade 3, 7/13 nodes, ER+/PR+, HER2- Dx 1/2019, IDC, 1cm, Stage IV, metastasized to bone/other, ER+/PR+, HER2- (FISH) Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole)
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Jan 12, 2021 04:19AM Chicagoan wrote:

Ann,

Welcome to our Ibrance dance although I'm sure you would rather not be here. I've been on Ibrance for over 4 years and love it! The first few months were hard, as others noted-my hair thinned, I was very tired and my skin was quite sensitive. Now I barely notice that I am taking a drug. I have been able to stay at 125 mg the entire time and feel very good.

My tips for new users:

1. Drink lots of water-try for 72 oz a day.

2. Exercise as vigorously as you are able-outdoors if possible. Also incorporate yoga/stretching.

3. Eat Greek Yoghurt to help protect your mouth from sores and keep your stomach healthy (this tip is stolen from our beloved PatMcG). You have an edge here living in Greece!

4. Try to get lots of sleep at night-consider giving up caffeine and alcohol to help with this. Take naps only on days when you are exhausted.

I was very worried about starting Ibrance too but it has been a life giving drug for me.

Best wishes!


Dx 9/21/2016, IDC, Left, Stage IV, metastasized to bone, Grade 1, ER+/PR+, HER2- Radiation Therapy 9/27/2016 Hormonal Therapy 10/5/2016 Femara (letrozole) Targeted Therapy 10/27/2016 Ibrance (palbociclib)
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Jan 12, 2021 04:20AM aprilgirl1 wrote:

Annadou,

Welcome to the Ibrance thread, I am glad you found us. I was dx with stage IV breast cancer in my superclavical node(s), mediastinal nodes and a few other nodes in my chest. So far, no mets in bones/organs. I have been on Ibrance and Fulvestrant for a bit over a year (started in November 2019). Like Cureious mentioned, it is common to have the Ibrance dose reduced due to low neutrophils at the end of a cycle. I just started on 75 mg last night (cycle 14 or 15?) It seems that every couple of months I needed to take an additional week off between cycles to allow my neutrophils to come back up and start a new cycle.

I did consult with a Radiation Oncologist when I was dx and their opinion was that radiation was not a good option due to the locations of the nodes, similar to what you have heard. I have received a petscan every 3 months since starting (first pet was technically 4 months after starting Ibrance/Faslodex). My petscans have shown no evidence of active disease and no FDG uptake since my June of 2020 petscan. I know this won't last forever but I am extremely thankful that I am responding well.

Side effects: In my case, I have had minimal side effects and feel really good. Initially, I did have a couple of mouth sores (like canker sores) and mouth wash helped. I did have fatigue. I contribute some of the fatigue to symptoms from my cancer and I felt really, really sick. I had no voice (paralyzed vocal cord from lymph nodes, and a significant pressure on my windpipe that made it hard to sleep). As I started treatment, these symptoms started to go away which helped me sleep better and also helped me emotionally. On the 125 mg I had some constipation, which is unusual for me. It was less on 100mg, as was the fatigue. Every cycle is a bit different. I had constipation one month, but didn't have it again for 3 months. So it is hard to say if it is Ibrance, Faslodex or ? I have lost hair - not sure which med is to blame. Normally I have very thick hair. I can tell it is thinner due to seeing it all over my floors (ha) and when I put my hair in a pony tail I have to wrap the rubber band 3 or 4 times when normally I could barely wrap it twice. My hair stylist has also noticed. I don't think the average person would think my hair is thinning but I sure can tell.

I work full time. I am self employed (residential real estate broker) and I was initially concerned if I could continue to work, would I feel ok etc. I am happy that it has not been an issue and for me work is a good distraction. I can set my own hours but selling real estate is not a 9 to 5 job and I consistently worked more than 40 hours a week. I have been selling for 10 years and ironically, 2020 was my best/highest amount of sales to date.

Keep in touch, definitely read through this thread and don't hesitate to reach out. I have so much gratitude to all who have helped me as I started this treatment and continue to help me as we all navigate our cancer treatments and life.


recurrence in lymph nodes (superclavicle/mediastinal)"You can do it like it's a great weight on you, or you can do it like it's part of the dance." Ram Dass Dx 11/7/2008, IDC, Left, 1cm, Stage IB, Grade 2, 0/3 nodes, ER+/PR+, HER2- Dx 11/13/2019, IDC, Left, Stage IV, metastasized to other, ER+/PR+, HER2-
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Jan 12, 2021 08:42AM SondraF wrote:

If you can find Colgate Peroxyl in a pharmacy that works real well on those mouth sores.


Dx 9/27/2019, IDC, Right, 5cm, Stage IV, metastasized to bone, Grade 3, ER+/PR+, HER2- Targeted Therapy 11/29/2019 Ibrance (palbociclib) Hormonal Therapy 11/29/2019 Femara (letrozole), Zoladex (goserelin)
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Jan 12, 2021 12:03PM snooky1954 wrote:

Nkb, you are correct very easy therapy. I will find out Fri. if it's still working. Best to you


Dx 7/2017, IDC, Right, 4cm, Stage IIB, Grade 2, ER+/PR+, HER2- (FISH) Dx 8/2018, IDC, Right, Stage IV, metastasized to lungs Targeted Therapy 8/14/2018 Ibrance (palbociclib) Dx 11/1/2018, IDC, Right, Stage IV, metastasized to bone/lungs Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Arimidex (anastrozole) Chemotherapy Xeloda (capecitabine) Chemotherapy Taxol (paclitaxel) Radiation Therapy Bone
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Jan 13, 2021 10:22AM annadou wrote:

Thankyou all for taking the time to reply

I get the first injections tomorrow after an ECG and triplex which I presume will be ok and will become an “Ibrancer “on Monday

All of your experiences and comments are helpful

SondraF

I too am a Brit but just changed to Irish nationality so that I can be an EU citizen here in Greece and avoid a whole bunch of admin that will be created with Brexit

I see that things are getting very serious in the Uk and USA with COVID-19 I do hope you are all coping and staying safe I asked my oncologist if I should have the vaccine and his reply was there is no protocol atm for my situation

Best wishes to you all

Anna


Dx 3/13/2009, IDC, Left, <1cm, Stage IIB, Grade 2, 4/21 nodes, ER+/PR+, HER2- (SPOT)
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Jan 13, 2021 10:50AM SondraF wrote:

Anna - ah, was wondering as your English was very good, although I know plenty of Greeks with excellent english. Actually I am an American in the UK, but here under EU rules (Swedish partner), so we can at least get out when its time to go. No faith at all in this goverment!

Dx 9/27/2019, IDC, Right, 5cm, Stage IV, metastasized to bone, Grade 3, ER+/PR+, HER2- Targeted Therapy 11/29/2019 Ibrance (palbociclib) Hormonal Therapy 11/29/2019 Femara (letrozole), Zoladex (goserelin)
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Jan 13, 2021 12:42PM BlueGirlRedState wrote:

Has anyone ever experienced a rash on chest that may or may not be related to the various drugs, or surgery? Maybe something going on with lymphedema on that side? Radiation was on left side (opposite side) 11 years ago, so it is probably not radiation. Have been taking Ibrance, on cycle 17, and Arimidex. Had bilateral in 2016 for cancer on left side, 2 nodes removed on left, negative. The left side healed a lot better than the right side. I am now fighting a "new" cancer in the R-axilla. The CT 12 days ago identified a "thickening" in R-axialla, but did not say anything about the tumor. There is definitely thickening shoulder area and neck with a loss in range of motion, but no pain. Oncologist had me see a dermitologist for punch biopsy last week, waiting for results. I am worried and scared. have been fighting this cancer for 11 years. It is BC 3. I have one of those "bucket list" trips, rafting the Colorado through the Grand Canyon planned for April and will not let cancer or any treatment plan interfere. Last year's trip was cancelled because of Covid.

2009 ER+ left breast. 52 yrs. Lumpectomy, Sentinel node removal, negative. Radiation 6 weeks, tamoxifen 5 years. Dense lumpy left breast, normal right.

2016 ER+ left breast. Probably a new cancer, but unknown. 4 rounds TC Aug-Oct 2016, Bi-lateral (my choice) Nov 2016, no reconstruction. 2 sentinel nodes remove, negative. Anastrozole 1 mg starting May 2017. Joint issues noticed immediately. Stopped Anastrozole after 3-4 months due to joint stiffness in. After several months of no AIs, fingers were feeling better. Started tamoxifen March 2018.

2019 ER+ R-axilla. This presented itself as swelling in right arm. Ultrasound found lost of fluid but no clot, referred to lymphaphic therapist who immediately recognized that something was very wrong since on opposite side of node removal. Cancer Dx'd after more imaging and biopsy. PET showed no metastasis. Started Ibrance and Arimidex. At first regular CTs suggested tumor shrinking, but it get very confusing. Seeing lymphatic therapist and using pump. Could pump spread cancer through lymph system?

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Jan 13, 2021 02:53PM - edited Jan 14, 2021 02:16AM by cowgal

BlueGirl - is it an actual "rash"? The reason that I ask is that my recurrence of cancer was diagnosed with a punch biopsy of my collarbone on the side I had cancer the first time. I did not have a rash but rather a lot of swelling and some pain. I thought it was related to the lymphedema getting worse on that side and yes, I had radiation on the chest wall back in 2010 when I was IIB. I am trying to remember if it was discolored at all.

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Jan 14, 2021 01:52AM Tanya_Djamila wrote:

Blue girl I did get rashes. I’ve been on Ibrance 44 cycles. I had rashes not with every cycle. Onc told me to take Benadryl and if it didn’t work we could try steroids. Thankfully the Benadryl worked.

Tanya

Tanya Dx 8/19/2003, ILC, Right, 6cm+, Stage IIIA, metastasized to bone/other, 28/28 nodes, ER+, HER2+ (IHC) Dx 4/19/2017, Stage IV, metastasized to bone/other, 0/0 nodes, ER+, HER2+ (IHC) Hormonal Therapy 6/19/2017 Faslodex (fulvestrant)
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Jan 14, 2021 02:20AM candy-678 wrote:

Well ANC yesterday was 700 (after my 2 days off on the 5/2 scheduling). So holding Ibrance couple more days and rechecking lab. Maybe 5/2 schedule is not helping my counts. I have struggled with the counts the whole time, but more in the last 9 months. Sigh....

Found mets on CT for unrelated issue. I only had 2 treatments with IV chemo for the Stage II, then found Stage 4 and switched to hormone therapy/targeted therapy. I consider myself de novo. Also using Xgeva injections for bone mets Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole), Zoladex (goserelin) Chemotherapy AC Surgery Lymph node removal: Sentinel; Mastectomy: Left
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Jan 14, 2021 05:09AM KBL wrote:

Candy, that sucks. I'm sorry. I know you've struggled back and forth for a very long time. I hope this was something that will correct itself quickly.

Dx 5/1/2019, ILC, Stage IV, metastasized to bone/other, ER+/PR+, HER2- (FISH) Hormonal Therapy 6/24/2019 Femara (letrozole) Targeted Therapy 6/24/2019 Ibrance (palbociclib)
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Jan 14, 2021 06:08AM SondraF wrote:

Candy, how is your water intake and exercise? I was told that taking the stairs before my bloods can usually crank out a few more points on the ANC scale, but also last month I took a very long walk of an hour and a half the day before bloods and was over 1, while it was. 7 the month before. I also pushed three big glasses of water about 4 hues before. Not sure if they helped but it can't hurt, and both times ive been low its because I've slacked on water.

Dx 9/27/2019, IDC, Right, 5cm, Stage IV, metastasized to bone, Grade 3, ER+/PR+, HER2- Targeted Therapy 11/29/2019 Ibrance (palbociclib) Hormonal Therapy 11/29/2019 Femara (letrozole), Zoladex (goserelin)
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Jan 14, 2021 06:48AM candy-678 wrote:

Sondra- My water intake overall needs to be more. I usually drink 1 liter or so each day, my doctors have said a person needs 2 liters a day. On Wednesday, the day of the blood test, I went to the lab earlier in the day before my day's worth of water. So, maybe not as hydrated for the test, but should have been somewhat hydrated from the days prior. I do not think about doing anything different before the lab draw-- to skew the results. Just my normal routine. Exercise is nil. Always has been. Maybe guzzle water and jog in place before the next blood draw?? Hahaha. No I will just do my normal routine.

Found mets on CT for unrelated issue. I only had 2 treatments with IV chemo for the Stage II, then found Stage 4 and switched to hormone therapy/targeted therapy. I consider myself de novo. Also using Xgeva injections for bone mets Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole), Zoladex (goserelin) Chemotherapy AC Surgery Lymph node removal: Sentinel; Mastectomy: Left
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Jan 14, 2021 07:49AM - edited Jan 14, 2021 07:52AM by SerenitySTAT

BlueGirl - I had a bad rash shortly after starting Ibrance/Xgeva. It began at the back of my neck and spread towards one side of my upper back/shoulder. I was already on a daily antihistamine, but had just missed a dose. I added Benadryl at night because it was itchy. It took several months for it to heal. I continue to take my daily antihistamine (desloratidine).

Just remembered that the rash did appear on my upper legs, lower back, and non- lymphedema arm. Fortunately those disappeared fast and weren't itchy. ???

"Do not overlook the little joys!" (Hesse, 1905) 🐶☕️🛀🖼🥐🌲🎭 Dx 11/2015 IDC Left IIIC 10/11 nodes ER+PR+HER2-, 12/2015 Left Mast, 2/2016 4 AC+12 Taxol, 9/2016 Rads Nodes Chest wall 15+4 boosts, 10/2016 Tamox, 4/2019 Exemestane, 12/2019 Ibrance/Xgeva
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Jan 14, 2021 08:13AM - edited Jan 14, 2021 08:17AM by Cure-ious

Candy, I felt better on the 5/2 schedule but it didn't help my low ANC levels. Now I'm starting to have trouble with them even on the 100mg dose (latest was 510), altho fatigue is much improved. I tried the walking up and down the stairs for an hour before the draw and that didn't help either. Have not tried hydration, and I definitely will because that is always an issue with me in blood draws. I may move to Verzenio over this

Now for first time I have developed a sensitive (raw) area on the roof of my mouth- is this a response to Ibrance also? I took the capsule for years never had this but now I take the tablets, could it be due to contact? Am stopping Ibrance for a few days to see if this improves- is regular mouthwash helpful?


Dx 10/2003, IDC, Stage IIB, ER+/PR+, HER2- Dx 7/2015, Stage IV, metastasized to bone, ER+/PR-, HER2-
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Jan 14, 2021 01:43PM - edited Jan 14, 2021 01:44PM by KBL

I have to say I had a lot of mouth sores in the beginning, but I hadn't had any for quite a while. This past weekend I had some strawberries and blueberries. Bam, I have one on each side of my cheek. I haven't had fruit in quite a while. It does make me think that could be the cause of mine. I will experiment now. Regular mouthwash did not work for me.

Dx 5/1/2019, ILC, Stage IV, metastasized to bone/other, ER+/PR+, HER2- (FISH) Hormonal Therapy 6/24/2019 Femara (letrozole) Targeted Therapy 6/24/2019 Ibrance (palbociclib)
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Jan 14, 2021 01:46PM BlueGirlRedState wrote:

Rash or inflammation? Is it casued by Ibrance? There is redness on the right side of chest and some swelling next to armpit. On cycle 17 of Ibrance. Lymphedema is on right. Still waiting results of punch biopsy. Tumor is in the R-axilla. Also loss of range of motion with right arm. I've noticed the loss in range for a couple of months, but attributed it to an injury to the right shoulder 40 years ago catching up with me, getting older, and not working out at the gym. The redness is new. I walk/hike/x-country ski winter almost daily. Usually stretch at home, but not as much as I was at the gym. Hoping biopsy comes clean. So if any of you did get a rash from Ibrance, where was it, how long did it last, were you taken off of Ibrance.

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Jan 14, 2021 04:40PM Tanya_Djamila wrote:

Blue girl I had a rash some cycles. The rash was on my chest legs torso and some times back.

Cureious I used a prescription mouthwash. Many on here have suggested a particular brand. I hope you feel better.

Candy sorry to hear of your low numbers again. Sometimes I have taken an extra day or two off at the end of my cycle. It depends on how much fatigue I feel. Sometimes I feel ok and just slog through but it’s a real grind bc of the amount of months. I think we’ve both been on this regimen for about 3 years or so.

Tany

Tanya Dx 8/19/2003, ILC, Right, 6cm+, Stage IIIA, metastasized to bone/other, 28/28 nodes, ER+, HER2+ (IHC) Dx 4/19/2017, Stage IV, metastasized to bone/other, 0/0 nodes, ER+, HER2+ (IHC) Hormonal Therapy 6/19/2017 Faslodex (fulvestrant)
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Jan 15, 2021 06:57AM - edited Jan 15, 2021 06:57AM by Tinkerbell107

Re Covid Vaccine. Another nuisance with scheduling. I was planning to obtain the Moderna vaccine at work on 1/21. This is my off week from Ibrance. Suppose to obtain lab work before the vaccine to review ANC. I receive a message that my MO wants me off ibrance for two weeks after receiving the vaccine. This will screw up the cycle for the 2nd dose. So basically I will only be on ibrance for one week each month for two months. This sounds crazy but I understand the reason behind it for she wants me to have the best response. However I'm not sure of my comfort level. So I decided to wait another month after my scans in February.

Dx 8/23/2019, IDC, Left, 2cm, Stage IV, metastasized to bone, Grade 3, 5/6 nodes, ER+/PR+, HER2-
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Jan 15, 2021 07:24AM candy-678 wrote:

Tinkerbell- I get it. Nervous with being off Ibrance for so long.

I have an opportunity to get my Covid vaccine later this month (thru a volunteering situation). My MO says OK. But I need to be off Ibrance 1 week before and 1 week after the vaccine. And with the Covid vaccine being in 2 shots a month apart, I will be off Ibrance more than on over the next couple of months. But... would I rather not be vaccinated against Covid? NO. So I pray that the AI alone will hold the cancer at bay.

Found mets on CT for unrelated issue. I only had 2 treatments with IV chemo for the Stage II, then found Stage 4 and switched to hormone therapy/targeted therapy. I consider myself de novo. Also using Xgeva injections for bone mets Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole), Zoladex (goserelin) Chemotherapy AC Surgery Lymph node removal: Sentinel; Mastectomy: Left

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