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Sep 14, 2017 10:47PM
I begin Abraxane tomorrow Friday Sept 15th. My MO already lowered the dosage a bit to start and we will do weekly infusion with a 2 or 3 week duration to see if we can affect the bumpy rash on my neck, it's so superficial we can see if the chemo is working or not. I begin the prednisone taper today coming down from 100mg to 80mg that she put me on for the immuno related pneumonia that Keytruda spawned a month ago. She said it will be a little bit like driving a car with abraxane and the steroids, gas and brake, gas and brake, the immune system got too revved up and then we damped it a bit too much with prednisone now we add the chemo and it's like a dance. I'm hoping the abraxane helps a bit with the ascites too. That's really been my main problem, the swelling in my gut is such that I have no room to breathe or eat well. and peeing and pooping is a real chore just so much pressure my body isn't used to. And it's not typical ascites it's all little pockets of swelling in and around my nodes in the mesentery. They tried to drain for pathology two weeks ago and only got a 30 ml sample. Not enough to "characterize". Although the fluid didn't abjectively "appear" malignant. I do have a little pleural effusion still on bottom of my left lung but it is so much better and my pneuomonia cough is probably 99% gone. Just soooooo slow to make a turn.
The rashy bumps on my neck actually turned up in July they are like mosquito bites combined with a pimple, itch sometimes, leak fluid under the skin like blisters sometimes, probably just some rogue TNBC cells that leaked out of the lymph nodes in my neck that have been inflamming, swelling, going up and down since last fall. My recurrence really has been kept to the lymph nodes I have a PET from August 3 and a CT from August 17th that still show no speck of cancer in liver, lungs, or other organs. GO figure.
The Keytruda trial was interesting. Early on it looked like it was working, the nodes in my neck went down, but then other nodes in chest and gut started to inflamme this spring. Then I got hives for 2 months. Then I got fevers for two months. Then the gut node pain increased and now I have basically lymphedema in my gut that matches the lymphedema in my left arm (two sentinal nodes removed 4 year ago and the supraclavicular nodes that got my stage 4 diagnosis in Oct 2016) I'd be happy to answer any specific questions about keytruda that anybody has. I did it concurrantly with xeloda. Sometimes it's hard to know what drug was causing what. Incidentally, this trial had the option of doing xeloda by pill with keytruda OR weekly abraxane infusions. Guess I get to try the abraxane now afterall. Here's hoping fingers crossed, it helps me turn a corner. And soon. ~Nichole
spread your wings and show the world your stuff. Don’t be afraid to be who you are – each peacock feather is flawed and imperfect, but collectively they create something of great beauty. Your flaws are what make you PERFECT!
7/18/2013, IDC, 2cm, Stage II, Grade 3, 0/2 nodes, ER-/PR-, HER2-
8/9/2013 Lumpectomy: Left; Lymph node removal: Left, Sentinel
11/8/2013 Taxol (paclitaxel)
10/10/2016, IDC, Stage IV, metastasized to other, Grade 3, 1/1 nodes, ER-/PR-, HER2-
12/17/2016 Xeloda (capecitabine)