Treating estrogen responsive cancer naturally
Comments
-
Couldn't bring up the article. I eat I Tbsp Kerrygold butter in my coffee w MCT oil, but no milk
My daughter is lactose intolerant (my husbands side of the family all are) could you summarize the difference between those that are and those not from article please?
Thank yoy!
0 -
I can't believe I've been here over two years and didn't read anything about IGF-1 or dairy products. I do remember asking why dairy products weren't good and didn't get much of an answer. I just bought a big 2lb container of whey protein too. I also have two thyroid nodules that I will be getting biopsies on soon. Most likely caused by radiation according to the notes. And I am afraid the results will be indeterminate too. Would like to put the thyroid issue in the rear view mirror though. I bet if I stop the daily milk and cheese I might drop some pounds on the upside. And three lumps in my good armpit - maybe they will disappear. They've been US'd with nothing showing up. But I still worry....
0 -
Here is the article about IGF-1 and vegans and dairy products whose link I posted above...I copied the whole thing for clarity.
Insulin-like Growth Factor 1 (IGF-1) is a hormone with a similar molecular structure to insulin. It's vital to childhood growth and encourages cell growth and proliferation in adults. It's naturally produced by the liver and its production is stimulated by growth hormones. The levels of IGF-1 are highest in childhood and decline in adulthood. However, IGF-1 also promotes each of the key stages of cancer development: growth of the cancerous cells, vascularisation of cancerous tissue (blood vessel growth) and metastasis. In addition, it also prevents natural cell death (apoptosis) so the effect on cells with cancer potential can be dramatic.
This influence, when applied to a large number of 'at risk' cells over many years, could ensure survival of these cells and accelerate carcinogenesis (Jenkins et al., 2006).
Melnik et al. (2011) offers a valuable insight into this issue. As both insulin and IGF-1 are growth stimulators, any food or drink that stimulates the production of these two hormones is potentially health-detrimental. Milk and dairy products contain whey proteins which cause a rise in insulin, IGF-1 and growth hormone levels and as the authors explain, a typical Western diet rich in dairy and sugar (that also stimulates insulin production) shifts growth hormone and IGF-1 balance to abnormally high levels.
An analysis by Barnard (2004) is in agreement with the above and adds that the typical Western diet also contains a variety of mutagens and carcinogens that may increase the generation of oxygen radicals and lead to the initiation of cancer as well as other degenerative diseases. Barnard highlights the link between diet, lifestyle and increased levels of IGF-1, insulin and growth hormone. He suggests that a diet high in wholegrains, pulses, fruits and vegetables not only normalises the levels of these hormones but also contains large amounts of natural antioxidants that can prevent free radical formation and reduce oxidative stress in the body.
Vegan diets are associated with lower levels of IGF- 1 and higher levels of IGF-binding proteins 1 and 2 (these proteins limit the availability of IGF-1) compared with an omnivorous or even a vegetarian diet (Tantamango-Bartley et al., 2013). As a part of the EPIC (The European Prospective Investigation into Cancer and Nutrition) study, Allen et al. (2000 and 2002) measured circulating levels of IGF-1 of British meat-eaters, vegetarians and vegans. Compared with meat-eaters and vegetarians, vegan women had 13 per cent lower levels of IGF-1 and the concentrations of both IGF-binding proteins 1 and 2 were 20–40 per cent higher. Vegan men had IGF-1 levels nine per cent lower than others and this difference was considered enough to significantly lower the risk of prostate cancer. The intake of animal protein was linked with elevated IGF-1 levels and diet explained most of the differences in IGF-1 concentration between the groups.
As milk and dairy products consumption has been suggested to play a role in the development of some types of cancer, Swedish scientists decided to do a population study and investigate whether lactose intolerant people get less cancer (Ji et al., 2015). The cancer types in question were lung, breast and ovarian. The researchers identified nearly 23,000 lactose intolerant people through health registers and compared their lung, breast and ovarian cancer incidence with that of the general population. And the results showed their predictions were correct – the risk of lung cancer was 45 per cent lower, breast cancer 21 per cent lower and ovarian cancer 39 per cent lower in lactose-intolerant individuals. The study also looked at cancer incidence in close family members of the study participants but their cancer rates were the same as in the general population. The authors of the study suggested that dairy products might be increasing cancer risk due to the high amounts of fats, particularly saturated fat, and some growth hormones, such as IGF-1 (both of which have been linked to the development of cancer).
Almost all body cells respond to IGF-1 and diets increasing its levels are not only dangerous in terms of facilitating cancer growth but can have grave consequences in the case of hormone-sensitive cancers. Eliminating animal protein from the diet naturally decreases IGF-1 levels and therefore lowers the risk of cancer.
0 -
http://www.saragottfriedmd.com/does-meat-cause-can...
The main takeaway I got from this article is that frequent exercise does more to lower cancer rates than low IGF-1. That's good news, in my opinion. I don't have time right now to read the whole article, but I wanted to share this (which contradicts the vegan article a little bit).
0 -
Brian Rigby writes a long article with no studies referenced plus a book to push by Sara Gotfried MD
0 -
Here’s one on the IGF receptors
Researchers identify specific protein that helps breast cancer to spread
Researchers from the University's Institute of Translational Medicine have found an explanation for how breast cancer spreads to the lungs, which could potentially hold the key to preventing the progression of the disease.
Breast cancer remains the leading cause of cancer death in women due to metastasis (the spread of a cancer from one organ or part of the body to another) and the development of resistance to established therapies.
Macrophages are the most abundant immune cells in the breast tumour and can both inhibit and support cancer progression.
Insulin-like growth factors
The research team, led by Dr. Ainhoa Mielgo, conducted a study to gain a better understanding of how breast cancer associated macrophages support breast cancer metastasis with the aim of developing more effective therapies against this disease.
They found that these macrophages express high levels of specific proteins called 'insulin-like growth factors' (IGFs) 1 and 2 and this helps metastatic breast cancer cells grow in the lungs.
IGF-1 and 2 are hormones found naturally in your blood. Their main job is to regulate the effects of growth hormone (GH) in your body. However, as shown in this study, tumours can also express these proteins to help them grow and metastasize to other organs.
Significant reduction in metastasis
75% of breast cancer patients examined showed activation of IGF receptors which correlates with increased macrophage infiltration and tumour progression.
In patients with invasive breast cancer, activation of IGF receptors increased to 87%.
The researchers found there was a significant reduction in tumour cell growth and lung metastasis in pre-clinical breast cancer models when IGFs were blocked in combination with paclitaxel, a chemotherapeutic agent commonly used to treat some of the most aggressive types of breast cancer.
The results of this research study have been published in Oncogene.
Improving treatments
Dr. Mielgo said: "Our findings provide the rationale for further developing the combination of paclitaxel with IGF blockers for the treatment of invasive breast cancer.
"A better understanding of the mechanisms underlying the metastatic spreading of breast cancer is critical to improve treatment and patient outcome."
Lucy Ireland, Ph.D. student in Dr. Mielgo's group and first author of this publication, said: "I am thrilled by our findings, as the combination therapy is more effective than the current treatment in pre-clinical models of breast cancer."
Explore further: Potential therapy identified for aggressive breast cancerMore information: Lucy Ireland et al. Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer, Oncogene (2018). DOI: 10.1038/s41388-017-0115-x
Journal reference: Oncogene
Provided by: University of Liverpool
0 shares
0 -
Regarding Marijen's post - this is good news for those who received Paclitaxel, perhaps. Now all they have to do is block the IGF-1. I did not have paclitaxel - I had Cytoxan and Taxotere - for IDC.
0 -
I find the findings on IGF very interesting. I, like GoKale received Taxotere and not Taxol, but considering they are both taxanes, I chose to follow Dr. Longo's fast mimicking diet with each of my treatments in an effort to drop my IGF levels at time of infusion. I have no idea if this will truly be of any great benefit, but I felt it couldn't hurt. Have you read his studies? There was enough scientific evidence for me to give it a try.
I have been lactose intolerant for about 4-5 years, so my dairy has been limited for some time. My only weakness has been cheese. I tend to stick with sheep or goat milk cheeses when I do enjoy, but I am going to be mindful in reducing those as well.
I'm not sure if I will continue intermittent fasting and a monthly go at the fast mimicking diet post chemo. Need to look into that more specifically moving forward. Does anyone practice
0 -
There is a great video posted by couragement at Aromatase Inhibitor and Walking Away regarding reducing recurrence 40% by daily fasting for at least 13 hours. Must see
0 -
Hi Marijen, thanks for noting it here. I forgot to post it here which is the most obvious spot! I am putting the video up for all to have easy access. Also check out other videos by Dr. Rhonda Patrick (also originally from UCSD!) and her work on cancer fighting agents, specifically sprouting broccoli. Good stuff! I am using the app (and they get to use my info for studies) from mycircadianclock.org. This is the work being done by Dr. Panda at Salk. Dr. Patrick interviews amazing, hard working researchers on things of interest to all cancer patients and survivors. She also has interviews with Dr. Longo at USC on fasting and chemo which are really fascinating.
My very best to everyone. May we all be well.
0 -
That interview was very interesting. Thank you for posting it. I'm wondering, are C Reactive Protein (CRP) and IGF-1 levels generally tested?
0 -
Couragement, I watched the second video with Dr. Valtar Longo, it’s very good and encouraging. I think I’ve been doing two meals a day for a year now in an effort to lose weight and spend less time cooking. But I had no idea how I was helping myself. I signed up for newsletters from MyFitnessFound.com too. I cannot take an AI anymore so needed to hear this re: 40% reduction with 13 or more hours fasting. Thanks!
0 -
Enjoyed the video. What I find confusing though is that they talk about fasting for 13 hours And restricting eating to 12 hours. That's 25 hours a day. So those of you who do this, what hours do you typically start and end eating? I am trying to figure out how I can consistently do this.
0 -
Junipercat, I haven’t heard of anyone getting those tests.
0 -
Okay, thanks Marijen.
0 -
Glad you enjoyed it. I am doing a 14-16 hour fast, and as they say in the video you get the best results when you start earlier in the evening vs late. I start at 4 to 4:30 pm and end my fast around 7:15 am, but set it up to end my fast at 6:30. If I want to eat with people I end my fast a little later. My husband does it with me and we love the less cooking factor! Do note that you can cheat 2 days out of 5 and have similar results. I thought what was fascinating was it is when you eat more than what. Turns stuff on its head! Although I do find that with one less meal I really make my food choices count, in order to get the best nutrient value.I am with you Marijen. I am not taking AI's and was terrified and shut down for a bit over that, but this gives me hope and a sense that I can do something. Interesting documentary on Amazon Prime called the Science of Fasting. One has to keep with it as it seems very odd, but it ends up with Longo at USC and shows how several countries, including England and Germany have floors in their hospitals devoted to fasting for healing.
JuniperCat, those tests are definitely not routinely run, but are good for checking on inflammation. I have several co-morbidities (pre my cancer hx) and was tested for c-reactive protein routinely, but it always came up normal. So even a normal one doesn't mean that there is not inflammation and it also means that cancer isn't always inflammation driven.
Best to all!
0 -
Thanks couragement. I’ll check Prime for renforcement. For all of you, I meant 40% reduction of RECURRENCE. That’s huge, along with exercise!
0 -
Right? I love watching videos for reinforcement! Keep's me motivated. How is the weight loss going with the fewer meals? I have lost 3-4 pounds with this new eating and have been doing for 6 weeks. First I dropped close to 10 in about 2 weeks then it slowly came back to a more usual weight. I am really hoping to lose about 15-20 pounds and don't mind if it is slow going, but I almost wonder if this put my body into a starvation mode and it wants to hold on to what it has!
0 -
Well I didn’t think it was working but maybe since Christmas I’ve lost 10 lbs. i think I just got tired of extra eating, not as hungry as before. So right, I try to make my meals nutritious and almost never eat out. Too much salt for one thing. This way I know what’s in my food!
I’m going for more lbs off too
0 -
Well done on the 10! Yes, our home cooking can keep us healthier for certain. Steady on! I am right there with you.
0 -
Thanks, couragement... this is all so interesting.
0 -
Wednesday night into Thursday, I fasted from 6:15pm to 6:15am. That went really well, but it was only a 12 hour fast. Last night, I fasted from 7:15pm to 8:15am. I survived that but found it difficult to do my walk/run on the treadmill without coffee, and then I had to carry my breakfast and coffee to the office, spilled some of the coffee on my walk from the parking lot. So I will try to restrict the eating from 5:15pm to 6:15am so that I can at least drink coffee before the gym. Will be tough on the nights I have to cook because I get home about 4:45pm - so I am thinking it will be a VERY simple dinner - some raw broccoli and a few nuts and seeds. Lucky for those whose husbands who are willing to forgo dinner. My husband is extremely compliant with whatever I prepare for dinner that fits my new nutritional requirements - but no dinner is not an option for him.
0 -
GoKale, I usually manage to leave 13 hours between dinner and breakfast. It takes a bit of practice, but isn't that hard once you get used to it.
As far as dinner, I make a big batch of something and eat it 3 days running.
0 -
Interesting about the fasting. Guess I have been somewhat "naturally" doing around a 12 hour fast almost daily. Does juice count as breaking a fast? Most days, I have some juice with a daily powdered supplement I take in the AM along with meds, around 7:45 - 8 AM. Try not to eat after 7 pm and breakfast when I get to the office around 8:45 to 9 am.
0 -
-
I am on a nearly all raw vegan diet with a few exceptions: my breakfast is the Budwig cottage cheese with flaxseeds and oil, and here and there I have a bone broth. No red meat, no any other daily products. I am also entirely sugar free cutting even on fruit intake.I juice veggies, sprout all kinds of seeds and beans, and grow my own wheatgrass for juicing. I try to go to the gym 2-3 times/week. I am on the following supplement regimen prescribed by my naturopathic oncologist:
- Vit C
- Vit D
- selenium
- systemic enzymes
- vit b complex
- vit e complex
- cod liver oil
- chlorella
0 -
0
-
As far as breaking the fast, I googled whether vitamins count as breaking the fast, and found an opinion stating "no, it doesn't count". It's whether something you ingest has calories. This includes black coffee and straight tea. I also read online opinions on the benefits of fasting and the dangers of fasting. My only concern is whether fasting increases cortisol which would increase inflammation, I think.
Cholesterol - Yes, I think high cholesterol is a problem regarding cancer. I've had years of high cholesterol which may have contributed to my cancer along with birth control pills. But I don't think high fat foods such as olive oil, avocados, etc. negatively impact cholesterol. I really think sugar, refined carbs have a huge impact (negative) on cholesterol.
0 -
I just received my IGF-1 levels after a 13, if not 14 hour fast ---- through the roof!!!
50-190 ug/L is the parameter and mine are 256 !!!
I had zero sugar the night before.
Now I am concerned...
Has only else gotten levels tested?
Edit: in my state of extreme panic my husband reminded me that my bloods were taken after 3 days of Zarzio injections so I’m assuming (and hoping) levels were off due to that. I’ll have levels tested at another date but interesting to see how many days levels would return to normal.
0 -
I have only had fasting insulin levels tested, not IGF-1. These were pretty low. High insulin stimulates the release of IGF-1 in the liver. I do have dairy products as I need the calcium but avoid sugar and processed carbs enough to keep my blood glucose and insulin low. I have been on some kind of intermittent fasting regime for many years. I started out with a 17-hour fast which lasted a year. Then dialled down to 12-13 hour fast. My CRP (inflammation marker) is also pretty low as well as cholesterol levels. I try to get 7 portions of fruit and veggies and exercise daily along with taking Tamoxifen.
Dr. Longo's new book is out on Amazon: The Longevity Diet.
0
