Active Topics

See what others are discussing and join the conversation.

Join a current conversation

Ribociclib/Kisqali with Letrozole - Any one on this combo?
I am starting this new forum for all those who are on this newly approved drug combo. I started on Kisqali/Letrozole combo 6 weeks ago and so far it has been tolerable. Letrozole gives me joint pain and low back pain. My oncologist has asked me to take this on alternate days. Would love to hear from others about their…
Bodily feelings (side effects?) that are difficult to put into words
I was diagnosed with stage 2 breast cancer with a high oncogene score. I finished chemo and surgery and am now on letrozole and Kisquali (been about 6 weeks). I wonder how many others feel like "their body is dealing with something" but don't know how to put it into words. I do have some digestive issues, some joint pain,…
Early Stage Breast Cancer - anyone on Letrozole and Ribociclib?
Wondering if anyone has been diagnosed with Early Stage Breast Cancer and on AI/Ribociclib regimen? I’m going to start after radiation and wondering how your treatment is going and if there are any tips out there! Thanks in advance!
Nervous about switch from Letrozole to Exemestane
Hi - I have been on Letrozole for 2 years (invasive ductal carcinoma, node positive, did chemo and radiation, double mastectomy and oophorectomy...was diagnosed right after my 46th bday). Recently I've had neuropathy for the first time (it moves around/switches which limbs it affects...strangest thing). Ruled out…
Letrozole
Hi, I have been taking letrozole for 1.5 years and have decided to stop. I had stage 1 invasive ductal carcinoma. Treatment involved partial mastectomy, 20 treatments of radiation and letrozole 10 mg daily for 5 years. The hot flashes, insomnia and fatigue is really affecting my quality of life. I’m curious how many of you…
Doing Well on Aromatase Inhibitors (AIs)
I read a suggestion that someone should start a topic for women who are NOT experiencing severe SEs while taking Arimidex, Femara, or Aromasin. I'm about to start taking Arimidex and when I read about the potential SEs I get discouraged. Maybe others would also like to hear about positive experiences. We would love to hear…
AIMSS: How Aromatase Inhibitors Can Affect Hands and Wrists
AIMSS: How Aromatase Inhibitors Can Affect Hands and Wrists January 13, 2026 If you’re taking an aromatase inhibitor, you may have pain in your hands and wrists. Dr. David Bozentka explains the syndrome. Float RightMediumAccessibilityDelete Bone and joint pain are some of the most common side effects of aromatase…
Letrozole and Tendonitis?
Hello all! I am coming up on 6 years of AIs with Letrozole being the most recent one. I had been on Arimidex but developed trigger thumb and fatigue over time so I switched to Letrozole. I have been okay for the most part but I now have tenosynovitis in my left wrist which won't go away and a new tendon issue on the top of…
Aromatase Hormone inhibitor “5 year pill” side effects?
Has anyone used these? what were your experiences as far as side effects? cardio-muscular-bone damage?
Giredestrant Reduces Recurrence Risk More Than Tamoxifen, Aromatase Inhibitors
Giredestrant Reduces Recurrence Risk More Than Tamoxifen, Aromatase Inhibitors Dec 22, 2025 Results from the lidERA trial suggest that giredestrant could be a new standard of care for early-stage hormone receptor-positive breast cancer. Read more…
Zoladex/Goserelin + Letrozole + Kisqali
hello! I was diagnosed with Stage 2 ER/PR+ HER2- lobular breast cancer late last year and have completed surgery and preventative chemo as there was no sign of spread post-surgery. I started hormone therapy consisting of monthly injections (Zoladex) and daily Letrozole in July and will add Kisqali this month. My hair is…
ILC LFET SIDE 46 MM , RIGHT SIDE 5MM IDC
I have diagnosed with ER/PR + HER2 negative on April 21st 2025. Bilateral mastectomy done with reconstruction ,tissue expanders in place . I will start radiation soon my left side . DXoncotype 16 Worried for the side effects of radiation .On Letrozole and lupron since May 2025
Verzenio & Letrozole
Second bout with breast cancer: I am a 61 Year Old woman diagnosed February 2025 Her 2 Positive 8 cm x 6 cm (large) breast tumor with metastatic skin cancer on ribs (considered stage 4) being treated with Letrozole and Vernizio I was first diagnosed in 2021 with a similar tumor but no metastases at that time. I received…
Stopped Letrozole for One Month
I am curious if anyone has taken a break from hormone inhibitors for a month. I had surgery in January 2023 for invasive lobular cancer of the left breast and had a mastectomy. My oncotype was 13% and I had radiation therapy for 5 weeks. One lymph node was positive. I have been on and off hormone inhibitors since last…
PET-CT scans after node recurrence (and while on Verzenio)?
Hi everyone. Looking for some advice from all you wise, brave folks. I had IDC 18 years ago; ER+, PR+, HER2 neg/double mastectomy/chemo/tamox/negative sentinel nodes. A year ago was diagnosed with an aggressive axillary node recurrence; surgery to remove 8 nodes, 4 pos, 4 neg. Went on letrozole, had radiation, now 9 months…
Switching from AI to Tamoxifen - Bone loss
Hi, I just met with a new oncologist after the retirement of my previous one. I have been on an Aromatase Inhibitor for six years with worsening bone loss. Taking Fosamax. The new oncologist suggests switching to Tamoxifen. Total treatment time would be 8 years vs. target of 7 if I stay on AI. Has anyone had or considered…
Pre-Menopause Oophorectomy Side Effects Worse With Letrozole?
I had a bilateral salpingo oophorectomy (BSO/ovary removal) on March 4th. I had not begun menopause (based on MO ordered hormone tests). The side effects I've had since that surgery are debilitating. I'm supposed to start taking Letrozole tomorrow. I'm trying to find out (no response from SO or MO) if the symptoms will…
Are you dealing with infections or bandaging during palliative care??
Hi everyone. I'm starting this topic because I haven't found a similar one to help answer questions and offer me advice. I know I'm a rare case managing my own palliative care, in Asia, while under the care of a great doctor who's using both eastern and western medical traditions. I'm on hormone therapy (Tamoxifen then…
Break from Letrozole for 2 1/2 months
I will be going back on letrazole after a break after 2 1/2 months due to sudden onset of constant palpitations and one short episode of a/fib. I had to get a cardiac work up and getting that done has taken time. Getting in to see a cardiologist, wearing a zio patch for two weeks, waiting for the results and then scheduled…
Did women who had an easy menopause and periods, have an easy time with IA?
I'm supposed to start Letrozole. I just got over chemo and RT and just waiting to get back on my feet before starting this poison. Trying to talk myself into it. I can't seem to get straight answers that satisfy me. Get tired of the Standard of Care or One Size Fits All. Why isn't a hormone test done at the beginning and…

Polls, Announcements, Requests

From the team

In Treatment for Early Stage Disease (I-III)? Join us on Zoom, Tues & Thurs weekly!
Join our weekly virtual support group for all who are planning or going through active treatment for early stage disease (I-III). If you've just been diagnosed and are planning surgery, chemo, or radiation, join our weekly Zoom Meetups. We have two meetings for you to register for: Register here: Tuesdays at 1:00 PM…
Connect with others by creating your profile! Here's how.
We know this community is so important, so we’ve made it even easier for you to connect with others. With this update, you can: ✅ Share more about yourself so others can get to know you ✅ Find members with similar experiences using profile searches ✅ Get personalized support and resources from our community team How to…
How to use member profile search to find others like you
Using the information you and others share, you can find others based on: 📍Location (ex: lives in Philadelphia, Pennsylvania) 🌍Demographic (ex. is Black or African-American) 🧬Diagnosis (ex: diagnosed in the last year with stage II, ER+, PR+, HER2- breast cancer) 💊Treatment (ex: has been treated with a unilateral…
Were you diagnosed young (under 45) with breast cancer? We'd love to hear from you!
Were you diagnosed with breast cancer at age 45 or younger? Or are you caring for someone who was? Navigating this experience can be lonely — it can sometimes feel like no one gets it. What do you wish others knew about having breast cancer at a young age? What do you wish you had known? Your answers may help others. Click…
How has a nurse helped you through breast cancer?
At Breastcancer.org, we often hear how much nurses mean to people going through breast cancer. It’s the nurse who often explains the diagnosis and treatments to you in simple language, helps manage your side effects, offers you reassurance, and connects you with the care you need. Nurses are also a source of emotional…
What topics/experts would you like to see on The Breastcancer.org Podcast?
Hello, I'm Jamie, senior editor at Breastcancer.org and host of The Breastcancer.org Podcast. I'd like to make sure the podcast is answering questions that Community members have. Are there topics you'd like to see covered? Experts you think I should talk to? Do you want to share your story? Questions you want answered?…
Poll: What's the one piece of advice you'd give to someone newly diagnosed with breast cancer?
Getting diagnosed with breast cancer can be scary. If you had a chance to share with a newbie one piece of advice to get them through, what would it be? Choose from the options below or add your own in the discussion to give new folks a sense of calm and understanding.
Your Voice Can Shape Clinical Trials | Participate for $100 gift card!
Researchers at Mass General Brigham, Dana-Farber, and Harvard Medical School are exploring how AI chatbots can make clinical trial consent easier to understand. They’re inviting adult cancer patients across the U.S. to join a virtual focus group and share their ideas. Participants will receive a $100 gift card. Spots are…
Managing the Holidays and Breast Cancer - how are you coping?
The holidays can bring lots of emotions — and lots of people. How do you handle gatherings, conversations, ongoing check-ins, or expectations from loved ones this time of year?
Poll: This time of year, what are you prioritizing?
The holidays can be overwhelming — what matters the most to you this year? Take a moment to answer our poll and elaborate in the thread below. Happy holidays to you each, no matter what or how you decide to celebrate!

Upcoming events

It’s OK To Ask: Breast Cancer and Breaking Taboos
Think back to a time in your doctor’s office when you really wanted to ask a question — but didn’t. Maybe you built up the courage and then changed your mind because it felt insignificant or you didn’t want to feel judged or be a burden. There are a lot of valid reasons why people hold back on asking for what they need. We…

View all

Welcome!

It looks like you're new here. Sign in or register to get started.

Unanswered posts

These posts are awaiting responses - can you help?

Check them out