Calling all TNs
Comments
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Luv and LovingMyMom - I don't post that much, but I just wanted to say that I am thinking of you both and sending all my positive thoughts and prayers your way.
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Thought this might cheer everyone up....so sorry for the mets that are still invading our lives. Be strong ladies!
Paul Newman
Only women of a certain era will fully appreciate this.... True story. (If you don't understand this, tell your mother, she'll get it!)
A Michigan woman and her family were vacationing in a small New England town where Paul Newman and his family often visited.
One Sunday morning, the woman got up early to take a long walk.After a brisk five-mile hike, she decided to treat herself to a double-dip chocolate ice cream cone.
She hopped in the car, drove to the centre of the village and went straight to the combination bakery/ice cream parlour.
There was only one other patron in the store: Paul Newman, sitting at the counter having a doughnut and coffee.
The woman's heart skipped a beat as her eyes made contact with those famous baby-blue eyes.
The actor nodded graciously and the star-struck woman smiled demurely.
Pull yourself together! She chided herself. You're a happily married woman with three children, you're forty-five years old, not a teenager!
The clerk filled her order and she took the ice cream cone in one hand and her change in the other. Then she went out the door, avoiding even a glance in Paul Newman's direction.
When she reached her car, she realized that she had a handful of change but her other hand was empty. Where's my ice cream cone? Did I leave it in the store? Back into the shop she went, expecting to see the cone still in the clerk's hand or in a holder on the counter or something! No ice cream cone was in sight.
With that, she happened to look over at Paul Newman. His face broke into his familiar,warm,friendly grin and he said to the woman,"You put it in your purse."0 -
Luvrving...i am so so sorry to hear this news...i have followed you ( secret stalker) and have always enkoyed your posts..keep fighting!
I am out of hospital after my marathon almost eleven hr surgery. They look pretty good..leftie got infection so lots of antibiotics..see doc thurs for post op...hoping all will be good to come home0 -
Annie - be brave! Think of how good peace of mind will feel.
Hopex3 - the steroids wreck havoc on my emotions. I hope you are feeling better soon.
Bernie - loved it!
Tomorrow I go for my second treatment. Last week it was gemzar/carbo this week, just gemzar. DH just picked up my neulasta shot from the Rx - he's going to give it to me Friday here at home. Not looking forward to that shot from hell.
I've ordered myself a new set of sheets, duvet and mattress topper.
Loving my new adjustable bed, just need an over the bed tray table and I'll be set!
DH bought me a new tablet to take to chemo, because I can't get my
iPod to connect In the infusion
room.
Ground chuck was on sale, so I'm making black bean & beef burritos
for dinner. Teaching DH, all my old standby dinners.
Big hugs all around!!!0 -
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Thymosin Beta 15A (TMSB15A) is a Predictor of Chemotherapy Response in Triple-Negative Breast Cancer
Br J Cancer. 2012 Oct 18;[Epub Ahead of Print], S Darb-Esfahani, R Kronenwett, G von Minckwitz, et al
TAKE-HOME MESSAGE
Investigators validated thymosin beta 15A levels as predictive of response to neoadjuvant chemotherapy in patients with triple-negative breast cancer.
Abstract
Background: Biomarkers predictive of pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) of breast cancer are urgently needed.
Methods: Using a training/validation approach for detection of predictive biomarkers in HER2-negative breast cancer, pre-therapeutic core biopsies from four independent cohorts were investigated: Gene array data were analysed in fresh frozen samples of two cohorts (n=86 and n=55). Quantitative reverse transcription polymerase chain reaction (qRT–PCR) was performed in formalin-fixed, paraffin-embedded (FFPE) samples from two neoadjuvant phase III trials (GeparTrio, n=212, and GeparQuattro, n=383).
Results: A strong predictive capacity of thymosin beta 15 (TMSB15A) gene expression was evident in both fresh frozen cohorts (P<0.0001; P<0.0042). In the GeparTrio FFPE training cohort, a significant linear correlation between TMSB15A expression and pCR was apparent in triple-negative breast cancer (TNBC) (n=61, P=0.040). A cutoff point was then defined that divided TNBC into a low and a high expression group (pCR rate 16.0% vs 47.2%). Both linear correlation of TMSB15A mRNA levels (P=0.017) and the pre-defined cutoff point were validated in 134 TNBC from GeparQuattro (pCR rate 36.8% vs 17.0%, P=0.020). No significant predictive capacity was observed in luminal carcinomas from GeparTrio and GeparQuattro.
Conclusion: In TNBC, thymosin beta 15A, TMSB15A gene expression analysis might help to select patients with a high chance for pCR after NACT.
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Karen - Good luck teaching DH how to cook. My efforts to do that were a disaster. Your bed setup sounds wonderful. I sure hope all your chemo tx are easy on you.
Heidi - Thanks for the information. I wonder how this will be applied to ca patients.
I check in on the web site Positives about Negatives. She often has interesting TNBC tidbits.
Finding joy today.......Jan
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I, like some of the other wonderful ladies on here don't post much, but stalk often and I constantly think of all of you during the day. I don't belong to a support group in person, this site and all of you are my support group.
My heart was saddened with Luv's news, but please know, you are in my heart and thoughts. You have always given so much of yourself. I am sending positive thoughts, hugs and emotional support your way for you and your family.
Dawn the same goes to you too...Fight with every ounce of your being and all of us will be beside you all the way...
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Inmate I remember having nightmares about roller coasters while doing chemo. No dreams..
Luv so sorry to hear of your dx, I am praying that radiation zaps those little mets! And thank you to your daughter for posting and keeping us all up to date.
ruth so sorry to hear about your mouth pain, praying it is nothing cancer related
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Luv - thinking of you.
Inmate - so glad to hear from you.
Ruth - thinking of you and praying there's nothing serious going on with your jaw.
Hello everyone....just wanted to check in to see how everyone's doing.
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Hi ladies!
Haven't posted in awhile but I am always reading your posts! My thoughts and prayers are with everyone facing recurrences. I know you will give your all to beat ca's ass!!
Just wanted to say that although I don't post often I find comfort in reading your posts and feel like I am not fighting this alone. I don't think I could have gotten through this year without having you all there. And now tomorrow I close a really difficult chapter in this journey as I am having my last taxol treatment and will be done with chemo! 16 treatments done... Never thought I'd say that. Seemed so far ahead looking back to June when treatments started. But it's finally here and I pray I never have to face it again :-).0 -
Melissa - wonderful news! I hope it's an easy one.
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Melissa, congrats on reaching the end of this chapter- onwards and upwards!
Hopex3, I suffered from terrible depression during AC treatments, just filled with doom and gloom. I had to remind myself not to speak to my mom during a certain time period after infusions. I wasn't sure if it was the chemo, or the early onset of chemopause (although one rather bitchy friend keeps reminding me that I am 45 so it is not really early in her opinion!), or a combination of the 2. The depression got a lot better with the switch to taxol, even though I didn't tolerate that regimen for other reasons and have since been changed to taxotere.
OBXK and Luv, the new regimens are going to blast those mets into oblivion! Stay strong lovely ladies! xo
YoungMom, welcome to the board. Sorry you are here, but happy you found us!
Mags, congrats on the new girls! Fingers crossed your leftie has a speedy recovery from the infection.
Inmate, sorry you are missing your sleeping dreams. Keep on believing you can fly and visualize it during your daydreams instead. xoxo
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Inmate: I remember having some pretty "steamy" dreams while on chemo.....could have been the steroids or could have been that I was reading 50 Shades?! Hard to say. Hope you're in dreamland again soon my Dear.
I am friends with Mags on FB and she wrote that her left one did not take so she's back in surgery today. Thoughts and prayers that this one goes better.
Melissa: Ring that bell loud and proud. Congrats on being done.
Gentle hugs to you all today. Off to make lunch for my JK kid and head to work. LOVE xo
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Well leftie did not make it. The flap has failed and must b removed today. Doc says we can try again in three months...sad turn of events but what are ya gonna do
Maggie0 -
aww,Maggie,that just sucks!!!!! you have had a hard time,were they able to do anything about the le? stay strong!!!
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Maggie darling, we are all thinking of you
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One day while jogging, a middle-aged man noticed a tennis ball lying
by the side of the walk.
Being fairly new and in good condition, he picked the ball up, put it
in his pocket and proceeded on his way.
Waiting at the cross street for the light to change, he noticed a
beautiful blond standing next to him smiling.
"What do you have in your pocket?", she asked.
"Tennis ball,? the man said smiling back.
"Wow," said the blond looking upset. "That must hurt. I once had
tennis elbow and the pain was unbearable!"0 -
Melissa and Tooky--congrats on getting to the end of chemo!
Luv--thinking of you and your family. You are such a source of wisdom and comfort on this thread.
OBXK--hoping the chemo is beating those mets in to submission.
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Maggie - sorry to hear about the flap. That stinks!!! Thoughts and prayers to you!!
Got my port installed today. Wasn't as bad as I imagined.
Hugs to everyone
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Inmate Saw your post about dreaming and wow...what timing for me. I just started dreaming again , like 3 nights ago. Just had this conversation with DH, chemo really messed with my mind for sure.
I always was a dreamer, and like you really enjoyed them for the most parts. Of course BC sent a few doozies but then once I started DDAC, they stopped. I just finished #10/12 Taxol and the dreams started again. I too found it weird not to dream at all.
Best wishes for cool dreams again.
ETA: LUV, sending healing energy waves your way , I always appreciated your responses
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Ok! So officially done with chemo! And now onto follow-ups every 3 months. There's where the anxiety comes in. But for now I am going to enjoy the holidays and my birthday in January!! First follow up in February.
Hope you are all having the best day you can have!! Thinking of you all. Anyone bravo g this nor'easter hope all is well and it is nothing like sandy! They was horrible. My parents have a place at the jersey shore that they cannot even get to yet. So sad. My kids are debated. But we will rebuild and it will be even better.
Have a great night!... When can I have a little celebration drink!! Lol0 -
Hello Ladies, I don't post often but do keep up on the thread. I'm so sorry to hear of Luv's spread but think radiation will zap them into oblivion. I do think and pray for everyone everyday.
Got my BRCA test results back today, turns out I'm BRCA1 positive, on to more surgery. A little pissed off at the world right now and scared of the double mx - afraid I won't be able to get reconstruction since righty was radiated after lx.
Hope everyone is doing well, it sucks that you have to be here but Welcome to all the new ladies, your in a wonderful support group. I wouldn't have made it thru without these ladies and congrats to the ladies finishing up chemo, life will slowly start to get back to normal.
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Luah, Thanks My scans were yesterday..I had a breast MRI...wow so uncomfortable..lol, but very greatful that my Dr. understands my worries and considers them! I also had the x-ray, but the dr. did not see anything with that...we are waiting on the official reports from the radiologist..I wonder if i should ask for more or should i go to a general dr. for my hip? Dr. thinks it just joint pain..arthritis...he did tell me to take advil.. I'm eager to hear results, and relieved that I had the opportunitiy to have these scans...
Luv---praying..praying...praying..
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Moe - hope the radiologist concurs!
Have you had chemo? Like rada it is the gift that keeps on giving. So sorry you are worried about your hip. I hope the Advil helps. Have you had a bone scan?
Heather - knowledge is power! I know it may not seem like that now, but those deadly gyn cancers, don't make themselves known, until it's way too late. We're all here to hold your hand, make you laugh and let you cry.
Melissa - hugs from hurricane alley. I feel your pain. I hope your parents shore home, dodged the bullet. Waiting is so hard! Raising a bottle of water to toast the end of your chemo!
Bernie - love it!
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Free to good home - a pair of C cup Knockers and 6 40c bras. I only wore them twice - I'd rather be a flat top.
So far, this treatment is not as bad as the last. Today was gemzar only.
Hugs all around...0 -
Heather - so sorry you have to endure more surgery but I am sending hope that this will keep you safe from further trouble.
OBXK - hoping your treatment knocks out the mets for good!
Dawn - thinking about you and sending hugs!
Stay warm and safe, ladies!
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Melissa...Congratulations on being done with chemo! And if your up to it, have that celebration drink!
Mags, I'm so sorry about your flap. Be strong and hang in there!
Txjunebug, glad your port was successful. I forget I even have mine.
Obxk..glad your treatment went well. I know someone from my home town that is on Gemzar and is having great success with it. I pray you do too.
I've been so tired this week but I'm not going to let the little f er get me!
Sweet dreams,
Erin0 -
Karen - I'm with you --- I'm totally flat on top, but have a muffin top middle. Glad you are able to tolerate your new chemo tx.
Luv - Good to hear from you today. Hope your rads aren't too rough on you.
I had an other 3 month check with MO today. Found out I'm 1% Estrogen positive! Never was told. MO says 1% is same as 0. Anyone told differently? She also tried to talk me out of taking Metformin. Not sure where I stand.
Special warm thoughts for those in path of the nor'easter. Jan
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Heather - I'm sorry you're BRCA1+. It definitely changes your tx options. I agree with Karen - its better that you know so you can do everything possible to prevent recurrence and ovarian cancer. I can honestly say I know how you feel. The day the MO called me, I fell apart. But I'm giving it all I got and hope its enough. We're all here to help you through this.
Mags - thinking of you and sending you healing vibes for a quick recovery. Sorry the leftie didn't make it. Another reality of BC that most people don't know.
Luv - good to see you!
Karen - keep kickin' cancer's ass!
To everyone new - sorry to see you here but glad you found us.
And finally to all - thanks for helping me get this far. This is the time for cancerversaries and I don't know what I would've done if I hadn't found such a wonderful group of ladies. ((((Hugs to you all))))
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Hi all, been awhile since I posted though I've been checking in on you all. Inmate, I hope you are feeling better - I think about you a lot. OBXK and LuvRVing, I am so sorry to hear of the mets, you are both in my thoughts as well - stay strong.
Me, no real BC news - I'm in limbo as I can't reconstruct my half-boob until next year. I occasionally have the usual recurrence anxieties, but I've been so busy I can't spend much time on them. My main issue is that my job has been making me utterly miserable and horribly stressed out, and we know stress leads to cancer... but I'm the primary breadwinner and if I up and quit I don't think we can stay afloat. I feel like my job has not been at all sympathetic to my situation... I've had BC not once but twice, I have lots of doctor appointments, I have kids, they get sick... and work fights me tooth and nail about every hour I miss. Not sure if I'm asking for "special" treatment or not, but I feel like I deserve... something? Some compassion, sympathy, understanding because of what I've been through? Anyone else ever feel this way, that you were... owed?
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