Ringworm drug for dogs (Fenbendazole) might also cure cancer
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I love that prayer Sonia. Amen to that.
Frisky, it is so hard to live with uncertainty. So draining. Did you post the article about high dose melatonin taken 3-6x per day? Have you considered trying it? My wife is going to take melatonin throughout the day. She started yesterday, and it didn't seem to impair her sleep.
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Husband, I did not read any article but an alternative practioner swears by melatonin. He claims that it works the same way as Marijuana but a whole lot safer. I took high dose for awhile but then it messed with my sleep. Good luck to your wife!
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I have been on 20 mg melatonin because it also has sidebar properties that are anti metastatic. Much like metformin, statins, etc do. It's another one. 20 is a high dose and ideally it is 1 x a night at the same time because part of the help is smoothing out circadian clock.
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I recently viewed a video by an MD, Dr. Frank Shallenberger who recommends stage 4 cancer patients take melatonin 3-6 x a day. He claims hormone receptive cancers don't grow in its presence, and that keeping a high level of melatonin 24 hours a day will delay progression. He says for 95% of his patients, it doesn't interfere with their sleep. He recommends 60 mg 3-6 times a day, and says there are no harmful side effects. I'll see if I can find the video. I thought it was posted on here. But it must have been somewhere else.
https://www.youtube.com/watch?v=Roh4lQXneQg&t=3170s&app=desktop
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Husband thank you for this valuable information and posting the link to the video, which I urge everyone to study.
I knew nothing about the anti cancer effects of Melatonin, except, that in the metabolic theory of cancer, the story goes that the disease starts always with melatonin disfunction.
I just ordered 100g of pure melatonin from Bulk Supplements. I plan on integrating it in my protocol, and like your wife take it throughout the day, since it doesn't cause sleepiness unless there's darkness and quantities are well tolerated without SE.
I just took 20mg.
Thank you again and God Bless you
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That bulk supplements looks like a great place to buy stuff from. We are thinking of placing an order, then driving over the border to pick it up. Its legal, and much simpler than having them mail it directly to us.
If you are interested, read some old pubmed articles by P lissoni, who did all sorts of amazing research on melatonin and cancer.
(edit, corrected spelling of lissoni)
https://www.naturalmedicinejournal.com/journal/2010-02/overview-melatonin-and-breast-cancer
In a pilot study by Lissoni in 1995, melatonin showed benefit in women who had not responded to tamoxifen (TMS) therapy alone.51 Fourteen women with metastatic breast cancer who had not had a clinical response to TMX were given 20 mg of TMX at noon and 20 mg of melatonin in the evening. A partial response, defined as CT-confirmed reduction of lesions by greater than 50%, was noted in 4 of 14 patients (28.5%) with a median duration of 8 months. Two of these 4 responders had singular lung lesions, one had pleural metastasis, and the fourth had skin metastasis. Stable disease, defined as no objective regression or increase less than 25%, was noted in 8 of 14 patients, 2 of whom had progressive disease on TMX alone. Of note, circulating levels of insulin-like growth factor (IGF-1) decreased in all patients on melatonin, with a significantly greater decrease in those who had a clinical response. Further, 6 of the patients enrolled, and 2 of the 4 responders were estrogen receptor–negative, yet had previously been given tamoxifen due to ineligibility for poly-chemotherapy approaches. This study was done prior to the advent of aromatase inhibitors, which would certainly be applied today to postmenopausal patients who have progressive disease on tamoxifen. Nevertheless, this small trial demonstrates the possible use of a nontoxic agent to enhance the effectiveness of an otherwise ineffective therapy.
The second breast cancer trial by Lissoni's group evaluated high-dose melatonin in women receiving epirubicin chemotherapy weekly, but who had to delay treatment due to the limiting toxicity of thrombocytopenia. Fourteen women with thrombocytopenia were enrolled and given 20 mg per evening of melatonin for 7 days before beginning weekly epirubicin treatments. After 4 cycles, the induction phase of melatonin normalized platelets in 9 of 12 evaluable patients. There was no further platelet decline in these patients throughout the chemotherapy treatment. Tumor regression was achieved in 5 of 12 of the patients and no toxicities were noted. This small trial suggests that melatonin may enhance platelet production and decrease thrombocytopenia in breast cancer patients receiving epirubicin. Larger trials confirming this benefit to platelet-depleting drugs, including epirubicin, are needed in order to make such a conclusion.
It should be noted that Lissoni's work has not been replicated to date, and larger, well-controlled trials are needed to confirm that oral supplementation with high doses of melatonin confers benefit in patients with breast cancer. Also of note is that none of Lissoni's randomized controlled trials were done in a blinded fashion. Nonetheless, a meta-analysis of 10 high-dose melatonin trials done across a variety of cancers reduced the risk of death at 1 year (RR=0.66 CI=0.59–0.73), an impressive trend for an agent with such a low toxicity profile.52
Conclusion
Melatonin's role as an oncostatic and cytotoxic agent is well established. In regard to breast cancer, the increased risk of developing breast cancer in women working night/ swing shifts is demonstrated through numerous epidemiological studies. Prospective studies, assessing the incident risk of breast cancer, have corroborated the role of low melatonin as a risk factor through measurement of urinary levels. Further, there may be an inverse association between melatonin levels and tumor size in women with existing breast tumors. From a mechanistic perspective, melatonin's net antiestrogenic effects and anti-inflammatory, immune-modulating, and antimitotic actions continue to lend credence to the potential use of supplemental melatonin as an oncostatic agent in breast cancer. While definitive clinical trials on the effects of supplemental melatonin in breast cancer patients are yet to be done, it has been well demonstrated to be nontoxic at pharmacological doses; this low toxicity profile coupled with the benefits demonstrated in patients with various cancers including breast, make it a candidate for consideration in breast cancer patients, particularly those with late-stage disease.
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Thank you Husband for the research. I remember asking my nurse Pra a year and a half ago about Melatonin. She said she had read tons of research and was not convinced it worked. Well, poo on her!
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Cross posting here because I am not sure the Ibrance thread is the most appropriate for this matter.
Has anyone ever heard of/used a plant called Devil's Claw? Apparently it helps immensely with joint pains. In Italy it's the latest fad along with curcumin in terms of holistic alternatives.
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Daniel86: I've never used it, but have heard of it. Here's a little info I found--one of which includes possible drug interaction list. . . : https://www.webmd.com/vitamins/ai/ingredientmono-984/devils-claw; https://www.verywellhealth.com/devils-claw-what-should-i-know-about-it-89445; https://www.drugs.com/npp/devil-s-claw.html. It appears it is has anti-inflammatory/analgesic properties as well as possibly lowering blood sugar levels. All things that would generally be considered beneficial to cancer treatment from a naturopathic/alternative med perspective. I can ask on my Jane McClelland/COC FB forum if anyone there has used it.
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I've never heard about that plant ... but if you believe in natural therapies you can try homeopathy. If you want, take a look at this link
http://homeopatia-salud.blogspot.com/2012/10/proto...You'll have to translate to english.
Many times I've got good results with homeopathy, but I don't know if it works for pain caused by Ibrance or antihormonal therapy. Good luck!
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Hi fenben fellows. You are all in my thoughts ... especially Goldie and her daughter.
I have a doubt ... since 3/4 days ago I have been having a lot of pain in my whole body, and taxol neuropathy seems to have returned ... (I'm not in any treatment at this time, I'm waiting for rads) I'm just taking 250 mg of fenben every day...
Today I read in Joe's blog that fenben causes neuropathy...
Anyone else who has increased the dose is noticing something similar?
Hugs to all
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Interesting... my MO was negative about me doing mebendazole when I am NED due to neuropathy possibilities. .
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Dear Frisky, I read your PET report over and over again and don't find it too negative - minor changes mean they can be reversed quickly if the right thing is done. Sure now, what is the right thing? You probably are the best C researcher I know (well, you listen to your gut too, what most of these guys never do as it is not their body that suffers), and increasing FenBen weekly doze seems very logical, as far as you don't experience some negative effects. FenBen is not only on our list but is already in our drawer.
Dear Daniel, as I know devil's claw can also be applied externally too, so I believe drug interaction would be minimal. Is that what you worry about? I know that Hyaluronic Acid complex (taken orally) is very helpful for joints but don't know anything about their interaction with other drugs:/
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thank you BSandra, I'm not concerned either, since I didn't expect anything that different from what they found. I am continuing with the protocol and will keep on adding to it as needed.
I'm not suffering from neuropathy and would love to understand more about the complaints as I find it absurd that this tiny amount of medication can cause damages normally associated with the traditional treatments.
Sonia, so sorry to read about the pain and neuropathy. I hope you feel better soon. I was wondering, did Joe himself put out a warning, or were various people complaining on FB?
Last month he debunked the issue of liver damage associated with dosage, I'm sure he will debunk this issue as well, as it doesn't make any sense at least to me as joe himself would have been the first one to suffer most from such a problem . Well...I hope it's not true...please keep on posting about this.
One more thing...the FZ at the recommended dose comes without warnings, my Doxil comes with 12 pages of warnings and the Xeloda before it around 8 pages..Humm....
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Hi Sonia, I'm so sorry that you are In pain again. I'm having my own battle battle with neuropathy. My last Taxol infusion was 7/15 and it's getting worse by the day it seems. My Onc said it's from Taxol or they possibly hit a nerve when they radiated my T10. Just last week I increased my FenBen to twice daily, one gram each time.
I have my 3mos. Nuc Bone scan and Ct this morning, so naturally I slept poorly last night and here I am awake before the birds! Have an Onc apt this Mon.. so will probably get results then
Just added two more new supplements to my arsenal. Grape Seed Extract and Ashwagandha. Besides being anti-cancer, they have high reviews for anti-anxiety and anti-depression. (last week added Beta Glucans and Serrapeptase. That's all the additions for a few weeks so that If I have a reaction, it will be easier to trace the source.
Goldie, honey, Praying for you and your daughter. Let us know how she is doing when you have the time.
warm wishes and HUGS to all.
Oh, Sonia, just had a thought! As you probably know if our bodies are too acidic (from the cancer) sometimes baking soda water mix will kill the pain. Yesterday, my back and shoulders were just aching/throbbing and I took the Baking soda. It helped a lot.
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Snooky I hope everything goes smoothly today and you get great results on Monday. Sorry to read about the neuropathy, I hope it goes away as the Taxol is cleared out of the body.
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Snooky good luck, praying as well for good results.
Snooky and Sonia, sorry about the neuropathy crap. I have not had it, I don't think, but occasionally my right hand and a little in my arm tingles, it doesn't hurt per se.
Frisky, glad you are ok with your results. I always set myself up that things will be worse, then I'm not disappointed. If it weren't for TM's being done, I wouldn't even think I had cancer!
My daughter is doing better every day. She see's a doctor on Friday for a follow up, and I believe she is headed back to her rock on Tuesday. I told her, no way are you to lift your suitcase, ask someone to help you. I don't like the looks of her scar, but it is not that old and she looks very swollen to me. As for me, I am good, just worried about her. May try a dose of FZ on Monday. I will tell you, I'm scared! We leave on Wednesday of next week for Kanab Utah. So if I do get another fever, hopefully it will be gone by then.
Edited to remove picture
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Goldie, I’m so happy to read your daughter is doing much better, I hope she gets the help she needs while traveling back home and that she experiences a complete healing.
Maybe you should listen to your body and stop taking the FZ for a while, it could be negatively interacting with something you’re taking
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Frisky and Goldie, Thank you for the well wishes. Had new results in my portal today.
My CA15-3 was 17.6 on July 29 that's up a couple of points which I know is no big deal.
Frisky, I asked my nurse about the compatibility test for Zeloda. She sent a message back to me, this is my Onc Prac talking to the nurse
"
per Carla there is a test to make sure that they do not have a gene that makes them super sensitive to 5FU. Not sure of the name. We can see if her insurance will cover it. It is not always a covered service.
please be patient with authorization process. Your insurance may take 15-30 days to respond once I can send it in. I will be in another office for a couple of days and Edie is off."I don't know how ins. could refuse if the manufacturer recommends it.
Well, have to go get ready!
Have a good day all
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Goldie glad your daughter is better wow at that incision
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Snooky...you’ll know right away if you’re allergic to X. It doesn’t happen frequently. When I asked to be tested my MO said it wasn’t necessary. I think insurance companies don’t pay for it, otherwise, the hospitals would do it. I don’t know of any tests hospitals won’t do as long as they get paid
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Hi there! Goldie, I'm so glad to know that your daughter is getting better! I hope everything is well and you don't have a fever anymore!
Frisky, I made a mistake, I didn't read that in Joe's blog, I read it in facebook, it was commented by user Jeff B (the one we know from the good results of his wife) Maybe it's just a coincidence, and my problem is not related to fenben. I don't know. Anyway, I will finish my 3 weeks of fenben daily and return to my old 3/4 schedule. Will see...
Santabarbarian: thanks for posting your MO's opinion. I have not told mine that I take fenben, I am sure she would also object.
Snooky: I'm going to try baking soda ... Lately I've been a bit lazy with my supplements. Sorry about your pain too... I wish you the best in your scans today👍
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Sorry to hear you are experiencing the return of neuropathy Sonia. My wife had terrible neuropathy on taxol back 8 or 9 years ago. I really hope the fenbendazole doesn't trigger it to return. I can see some commonality between the two drugs, as they both are microtubule inhibitors. Some people are more prone to neuropathy than others. My wife had it so bad, all she could do is lie in bed and cry. She said that even the foot steps of others caused her jolts of pain. About all you can do is figure it out by process of elimination. Stop using the fenben and see if it goes away, then once it goes away, restart and see if the neuropathy starts again.
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Sonia, I think husband's advice is very wise....that's what I would do in your position, and would not take it 7 on 7 but less 3 or 4 days off I think are necessary to detox the liver.
Damages from the traditional therapies is what I'm really worried about. Assuming the FZ will work for me, what good will it do if Doxil permanently damages my heart? We are all between the rock and the hard place here....
I'm truly sorry to read about all the women suffering from neuropathy....what you all have in common, including that woman on FB, seems to be theTaxol, but suspending the FZ and checking on the results will help determine the culprit.
As far as pains are concerned, my right arm and shoulder pains are greatly affected by magnesium citrate intake. I'm taking 400mg in the morning and 400mg at night with the calcium. Less than this and I'm in a lot of pain
Also, there’s a lot of research posted even on the MSK portal that Melatonin helps control and reverse some of the SE of chemotherapy and radiation and prolongs the effectiveness of medications...I’ve started taking it around the clock and its definitely affecting me, I don’t know about the cancer cells, but I feel different, more relaxed.
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Thanks for your advices guys. All that you said makes a lot of sense to me.
Frisky, you're right. The common point is taxol. I ended up with taxol just over 2 months ago, and my body probably didn't have enough time to regenerate.
Husband, I don't think your wife repeats the neuropathy, it's been many years since her infusion.
Looking on the bright side ... this reaffirms that fenben really works like chemotherapy!
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Hi Goldie,
So glad your daughter is getting better. FYI, I took Serrapeptase (an enzyme that digests tough proteins) to reduce some scar tissue a while back. It helps dissolve stubborn scar tissue and reduce inflammation, backed with scientific studies. Also works on biofilms. Nattokinase also helps with the biofilms though not as good for scar tissues. Not sure about its interaction with other drugs and supplements, so something to make sure about.
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Frisky, it sounds like your PET is not too far off from where you were before and that your liver mets are somewhat slow growing. I think there needs to be a change of 20% or so to even be considered "progression" based on RECIST standards. Is the minor ascites new? The omentum and peritoneal involvement is pretty common for ILC. Is that new? Interesting but not surprising that you feel more relaxed on round-the-clock melatonin. So far, it has not completely knocked you out as far as sleepiness is concerned? Have you had any sleeping issues (such as insomnia at night) given that round-the-clock melatonin may not permit the body to go through its daily sleep/wake cycle as far as melatonin levels are concerned? Very curious about the tolerability of this protocol. I believe I read that Husband said his wife has tolerated it pretty well so far.
Santabarbarian, you are not only NED but early stage, right? I am not surprised your MO is saying he/she won't recommend mebendazole. It is hard enough to get an MO to recommend it for someone stage 4 with active mets and few alternatives left. I get frustrated when doctors are resistant to prescribe things that are unproven by standard clinical trials but at the same time, do get it to some extent - first and foremost, they take an oath to do no harm. How can they in good conscience prescribe something that that they have no idea whether or not it will work or cause harm (or in your case, whether it is necessary). Regardless, I do think that some MOs have to say "no" to things all the while knowing that patients will do them on their own (and possibly in some cases, hoping patients will do them on their own). Some of it is a CYA thing. I don't share all of my complementary treatment wanderings with my MO, even though he is more open than most, so long as I am also taking traditional therapies. Usually, I only mention it in hindsight when he notices an improvement in my labs and I tell him what recent changes I have made.
Goldie, I am glad your daughter is past the surgery stage and doing a bit better. Her belly will continue to shrink from the swelling. The scar will heal over time. The scar is big but she is beautiful and the scar does not change that. It just makes her a bad ass
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Hi JFL, The omentum and peritoneal involvement is new...no symptoms except for slight pains in the liver area. That's the part that's the most troublesome to me.
I'm adjusting to the melatonin. It doesn't make me sleepy but it does relax me a great deal, and like a good Italian, I do tend to want to take a nap in the afternoon anyway. However, I'm not taking the amount prescribed. I'm going to have to work my way up slowly to that amount.
I appreciate my sharp mental faculties and wouldn't want to dull them too much. I'll let you know how my body adjusts to this additional protocol.
So happy to read your current treatment is working so well for you!
This afternoon I'll be getting my second Doxil infusion, the full amount this time. I hope it works on the lesions in the liver. Was that the case for you? I know you did the Y90, so I'm wondering if any chemotherapy actually gets to the liver or only makes the liver more toxic. What has been your experience?? Thank you
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so...do you remember how I was on that new and improved ibrance drug clinical trial?
Well, people have died and the trial has been revised to much lower doses....the nurse read a long list of side effects a few women suffered including death...I am horrified at what we put ourselves through to survive this terrible disease,
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Hi, I hope everyone is well today
Frisky, good luck with Doxil.
Some time ago, someone published a list of analgesics with anticancer action... I can't find it, today my head doesn't work ...
If anyone has an idea ... can you pass me the link? Thank you!
Santabarbarian, if you are reading this ... how was the radiation? Was it more tolerable than chemotherapy? I would appreciate your experience, if you want to send me pm. I don't want to hijack this thread ... Thank you!
Edited to say: Frisky, what you published about Ibrance trial is scary. Luckily you're fine ... How sad for those women ...
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