Treating estrogen responsive cancer naturally
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cole slaw is the bomb.
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Blueberries!Pterostilbene is a compound found naturally in blueberries. It is a chemical similar to resveratrol and is available in dietary supplement form. Preliminary research suggests that pterostilbene may reduce inflammation and offer antioxidant benefits.
Due to a lack of research, little is known about the safety of long-term or regular use of dietary supplements containing pterostilbene. Keep in mind that supplements haven't been tested for safety, and dietary supplements are largely unregulated.
In some cases, the product may deliver doses that differ from the specified amount for each herb. In other cases, the product may be contaminated with other substances such as metals. Also, the safety of supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established. You can get further tips on using supplements here.
Supplements containing pterostilbene are sold in many natural-foods stores and in stores specializing in dietary supplements. They can also be found online.
Uses for Pterostilbene
In alternative medicine, pterostilbene is touted for the prevention and treatment of the following health problems:
- Alzheimer's disease
- atherosclerosis
- diabetes
- high blood pressure
- high cholesterol
- insulin resistance
It's also said to protect against certain forms of cancer and preserve memory as you age.
Health Benefits of Pterostilbene
Although there is currently a lack of clinical trials testing the effects of pterostilbene, a number of preliminary studies indicate that pterostilbene may offer several health benefits.
Here's a look at several key findings from the available research:
1. Heart Health
Pterostilbene shows promise for protection against atherosclerosis, or hardening of the arteries, according to a 2012 study published in Apoptosis. In tests on human cells and on mice, scientists demonstrated that pterostilbene may inhibit the buildup of LDL cholesterol, or bad cholesterol.
The study also found that pterostilbene may help fight oxidative stress, a destructive biological process thought to be a key factor in the development of heart disease.
2. Alzheimer's Disease
Pterostilbene may help protect against Alzheimer's disease and aging-related cognitive decline, according to an animal-based study published in Neurobiology of Aging in 2012. In tests on mice, the study's authors determined that pterostilbene may help preserve cognitive function, in part by reducing inflammation.
3. Cancer
A number of preliminary studies suggest that pterostilbene may offer anti-cancer benefits. In a 2012 report published in the Journal of Surgical Research, scientists reviewed the available research on pterostilbene as an anti-cancer agent and found that pterostilbene may hinder cancer growth by altering cancer cell cycles, inducing apoptosis (a type of programmed cell death essential for stopping the proliferation of cancer cells) and inhibiting metastasis (the spread of cancer from one part of the body to another). The review also determined that pterostilbene's antioxidant effects may play a key role in cancer protection.
What's more, several recent animal-based studies and studies on human cells have found that pterostilbene may be effective for protection against breast cancer, prostate cancer, and colon cancer.
Using Pterostilbene for Health
It's too soon to recommend the use of pterostilbene supplements as a standard treatment for any condition, however, increasing your intake of pterostilbene by consuming blueberries on a regular basis may help enhance your health. Research suggests that a diet high in berries may help fight cognitive decline and protect cardiovascular health.
It's also important to note that self-treating a chronic condition such as diabetes with pterostilbene and avoiding or delaying standard care may have serious consequences. If you're considering the use of pterostilbene in treatment of a chronic condition, make sure to consult your physician.
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Chef, yes, garlic and beets are great together. I often roast beets, skins and all, along with garlic.
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dtad, I was just thinking life is not near as fun alone, congratulations on your son's marriage. That's all we want is for our kids to be happy
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Thanks so much! Very grateful that I was healthy enough to be there. When it was planned a year and a half ago I wasn't sure! Yes all we want is for our kids to be happy. Good luck to all...
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VITAMIN C is up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, according to scientists in Salford, UK.
The research, published in Oncotarget, is the first evidence that Vitamin C (ascorbic acid) can be used to target and kill cancer stem cells (CSCs), the cells responsible for fuelling fatal tumours.
Dr Michael P. Lisanti, Professor of Translational Medicine at the University of Salford, said: "We have been looking at how to target cancer stem cells with a range of natural substances including silibinin (milk thistle) and CAPE, a honey-bee derivative, but by far the most exciting are the results with Vitamin C.
"Vitamin C is cheap, natural, non-toxic and readily available so to have it as a potential weapon in the fight against cancer would be a significant step."
Seven substances
Cancer stem-like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and the triggers of tumour recurrence and metastasis (regrowth).
The Salford team set out to assess the bioenergetics of cancer stem cells – the processes which allow the cells to live and thrive – with a view to disrupting their metabolism.
Focusing on energy-transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically-approved drug stiripentol, 3 natural products – caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid – and experimental pharmaceuticals, such as actinonin, FK866 and 2-DG.
While they found that natural antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with Vitamin C, outperforming 2-DG by tenfold in terms of potency.
Evidence growing
Vitamin C has previously been shown to be effective as a non-toxic anti-cancer agent in studies by Nobel Prize winner Linus Pauling and was recently shown to reduce mortality by 25% on breast cancer patients in Japan. However, its effects on CSC activity have not been previously evaluated and in this context, it behaves as an inhibitor of glycolysis, which fuels energy production in mitochondria, the "powerhouse" of the cell.
Dr Gloria Bonuccelli, lead author and another member of the Salford team added: "This is further evidence that Vitamin C and other non-toxic compounds may have a role to play in the fight against cancer.
"Our results indicate it is a promising agent for clinical trials, and a as an add-on to more conventional therapies, to prevent tumour recurrence, further disease progression and metastasis."
Authors:
Gloria Bonuccelli, Ernestina Marianna De Francesco, Rianne de Boer, Herbert B. Tanowitz and Michael P. Lisanti.
Title:
NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting "stemness".
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Very interested in IV Vitamin C infusions. However one thing for sure is that it is not cheap!
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Dark chocolate supplementation for one week results in reduced abdominal circumference and improved cardiovascular disease markers.- GreenMedInfo Summary
0 0 0 New 0 0Google + Article Publish Status: FREEClick here to read the complete article.
Abstract Title:Effects of dark chocolate in a population of Normal Weight Obese women: a pilot study.
Abstract Source:Eur Rev Med Pharmacol Sci. 2013 Aug ;17(16):2257-66. PMID: 23893195
Abstract Author(s):L Di Renzo, M Rizzo, F Sarlo, C Colica, L Iacopino, E Domino, D Sergi, A De Lorenzo
Article Affiliation:Department of Neuroscience, Division of Human Nutrition, University of Tor Vergata, Rome, Italy. delorenzo@uniroma2.it.
Abstract:BACKGROUND: Normal weight obese (NWO) syndrome is defined as an excessive body fat associated with a normal body mass index and characterized by a higher risk for cardiovascular morbidity and mortality. Recent studies have demonstrated that dark chocolate (DC) has beneficial effects in the prevention of cardiovascular diseases (CVD) due to its anti-inflammatory and antioxidant properties.
AIM: The aim of the present study was to investigate the effects of DC consumption on lipid profile, inflammatory markers, biochemical parameters, and blood pressure, in NWO women.
MATERIALS AND METHODS: 15 women affected by NWO syndrome, aged 20-40 years, were included in the study. After a DC-free washout period, subjects received DC (100 g/die) containing 70% cocoa for 7-days. Body composition by Dual energy-X-ray absorptiometry (DXA) was performed at baseline. Blood pressure, anthropometric measurements, biochemical parameters and plasma levels of some cytokines were measured before and after DC consumption.
RESULTS: After DC consumption, we observed a significant increase in the HDL cholesterol level (Delta% = +10.41±13,53; p ≤ 0.05), a significant decrease of total cholesterol/HDL cholesterol ratio (Delta %= -11.45±7.03; p ≤ 0.05), LDL/HDL cholesterol ratio (Delta % = -11.70±8.91; p ≤ 0.05), and interleukin-1 receptor antagonist (IL-1Ra) (Delta % = -32.99±3.84; p ≤ 0.05). In addition, a reduction in abdomen circumference was observed. We also found a positive correlation between changes in atherogenic indices, and IL-1Ra, abdomen reduction.
CONCLUSIONS: Our findings suggest that regular consumption of DC could be useful in maintaining a good atherogenic profile, due to the favourable effects on HDL cholesterol, lipoprotein ratios and inflammation markers.
Article Published Date : Jul 31, 2013Study Type : Human Study
Additional Links
Substances : Chocolate : CK(681) : AC(98)Diseases : Abdominal Obesity (Midsection Fat) : CK(458) : AC(66), Cholesterol: LDL/HDL ratio : CK(484) : AC(61), HDL: Low : CK(305) : AC(50), Normal weight obese (NWO) syndrome : CK(10) : AC(1), Overweight : CK(3643) : AC(612)
Pharmacological Actions : Hypolipidemic : CK(1288) : AC(265)
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Thanks so much for posting these articles.
Dtad, congratulations on your son's marriage! May they have a long and happy life together!
I have been reading these posting with interest as I finally saw the main MO at a major university center (different from my usual MO) and I have made the decision to not take AI's. It has been a long time in coming and I am happy to be at this point. I struggled mightily with the decision, so I am glad to follow this thread! Now I just await being through some of this radical pain (joint pain from Herceptin, and PMPS from my BMX, and ocular shingles) so that I can get out and exercise!
Marijen, I look forward to hearing how the Vit C from Amazon feels once you are on it for a bit. Please do let us know.
Sending everyone my very best!
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Will do and I'm excited to find out if my waistshrinks in 7 days too! Although I can only have a small piece each dayas chocolate gives me headaches.
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Dadt uses a product call DIM. I must be super sensitive to anything that can effect hormones. I had tried it when I first stopped the Als and had a bunch of side effects. I tried it again starting on Friday, By last night I had horrible hip and back pain like I did on Femara. My mood is awful. Everything is triggering rages. This morning was really bad. It is getting better but not quite there yet. I even cut the amount back this time, taking one 5th of the recommended dose. Thought I would start it gradually.
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marijen....intersting product. Let us know how you do with it. I'm definitely going to do the vitamin C infusions. I found a doctor and Im having a consultation soon. From what research I have done the benefit of IV Vitamin C is that it does not have to be digested. I have Celiac Disease and this is a concern of mine. Good luck and keep us posted.
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Brutersrmom...interesting that you had the same SES on DIM that you had with Femera. I guess that means its working but the whole point of taking it is to reduce the SEs of an anti hormone. Maybe you should try a lesser dose of it. I'm now taking a supplement called Breast Health instead of the DIM. It does contain DIM but a slightly lower dose. My hot flashes are definitely less on the new supplement but I am concerned it might not be working as well. Going to go back to the standard DIM to see if it makes a difference. Good luck to all.
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Dadt I had to stop. I don't think I can lower it anymore. I had on capsule divide into 7 days. I am almost back to normal. I might look into breast health but right now I am working on weight management.
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Good luck and keep us posted...
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Plant substance inhibits cancer stem cells
Lab experiments show that the chemical compound damsin found in the plant Ambrosia arborescens inhibits the growth and spread of cancer stem cells. The similar but synthetically produced ambrosin has the same positive effect, according to researchers at Lund University and University Major of San Andrés in La Paz, Bolivia.
Photo: Rodrigo VillagomezPublished on Sep, 27, 2017 The plant Ambrosia arborescens grows at a high elevation in large parts of South America, and is traditionally used as a medicinal plant. The researchers have isolated the sesquiterpene lactone damsin from the plant and studied its effect on cancer stem cells in three different breast cancer cell lines. They have also performed similar studies using what is known as an analogue called ambrosin – a substance similar to damsin, but produced synthetically. The results show that they both have an effect on cancer stem cells.
"Both the natural and the synthetic substances inhibit the growth and spread of cancer stem cells in breast cancer cell lines. This is the first time that it has been successfully proven by research", says Stina Oredsson, professor at Lund University.
Already at low concentrations, the two substances inhibit the division and mobility of the cancer cells. This means that the tumour becomes smaller as cell proliferation decreases. In the present study, the researchers show that the actual number of cancer stem cells decreases.
Stina Oredsson emphasises that this is basic research and that the results are based on lab experiments involving cell cultures. However, she argues that the results are a breakthrough in cancer research as it may be the first step towards effective treatment of cancer stem cells, i.e. the cells believed to cause metastases.
"Different cancer cells have different abilities to survive chemotherapy. Cancer stem cells can be considered the most dangerous type of cancer cells, as they appear to have an inherent resistance to the chemotherapeutic drugs used today. Our results can contribute to the development of new drugs against cancer stem cells but, unfortunately, it takes a long time to get from basic research to usable drugs", says Stina Oredsson.
She and her colleagues continue to study damsin and ambrosin. They have also developed other analogues that show very good inhibitory effects on cancer stem cells. These results have not yet been published.
The collaboration project between Lund University and the University Major of San Andrés in La Paz, Bolivia, is funded by the Swedish International Development Cooperation Agency (SIDA).
Publication: Anti-cancer stem cell activity of a sesquiterpene lactone isolated from Ambrosia arborescens and of a synthetic derivative
Contact:
Stina Oredsson, professor
Department of Biology, Lund University
+46 46 222 94 97
+46 70 377 13 93
stina.oredsson@biol.lu.se0 -
Cool! Let's hope it leads to actual treatment. Sounds very similar to how the taxol drugs were discovered.
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How about progesterone? I don't see any information about high progesterone levels. I had 60/90 estrogen and progesterone levels. Is there natural treatment for high progesterone
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I intend to read through the entire thread, and I apologize in advance if this study has been mentioned, but I came across this yesterday and I thought I would share! Read through it carefully, it's very VERY interesting!
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Bosombuddy1, I have read everywhere that Flax is a good thing. I have flax cereal, flax muffins, flax oil, and intend to get a bag of flax seed. Also read it's good to grind up the flax seed. It was on my list yesterday and darn, I forgot. Thank you for the link. Good to see you!
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scaredashell -- This linked thread is in the Complementary and Holistic Medicine and Treatment section.
https://community.breastcancer.org/forum/79/topics/855475?page=1
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Back on the thread - 5 yr survivor here! - I am taking an Aromatase Inhibitor for ER + pathology. Onc says he wants to keep me on 10 years - I asked why and he said HEr2+ patients he keeps on 10 years as HER2 can have a late re=ocurrence. I have some bone loss and do not want to stay on this drug! What are you ladies doing alternatively for ER+ pathologies vs the Aromatase Inhibitor. I am a huge believe in alternative medicine and am open to your suggestions. Thank you.
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Hi dventi...I take DIM in leu of an aromatase inhibitor. I also do several other things to lower my estrogen naturally. Let me know if you want to talk more.
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Dtad,
What is DIM and would you share more as to how you lower your estrogen?
Thank you.
Coach Vicky
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Hi Dtad - Yes!! would love to talk more - looks like Coach Vicky has questions too - Look forward to learning more about what DIM is and your other approaches to lowering estrogen.
Coach Vicky - As I am , you are Her2+ - my Onc mentioned that the reason to extend me to 10 yrs is because my pathology is Her2+ -does not make sense to me.
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Artist,
Nearly everything you wrote aligns with what I understand. However, for other reasons, I eat as organic as possible. That's how it was in my grandmother's time..
Exercise as prevention of recurrence has as much research supporting it as Tamoxifen does.
UCSF was my hospital long, long ago. Dr. Don Abrams is there. He is chief of hematology oncology and directs the Osher Center for Integrative Medicine. He is a leader in the world of medical cannabis.
Thanks for the notes..
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Hi everyone...I would be happy to share. To start I lost 30 pounds and try to exercise daily. This alone had been shown to lower recurrence rates by 40 percent. DIM is a supplement made of crucerifous vegetables which lowers the bad estrogen that causes BC but not the good estrogen that we all need for our vital organs. I take a supplement called Breast Defend which contains DIM and other supplements that promote breast health. In addition I take melatonin, baby aspirin, mushroom extract and berberine to regulate my blood sugar. I also believe it helped me lose the weight. It mimics the drug Metformin. So far so good! Hope this helps. Good luck to all.
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Yes. Thank you DTAB!
I lost weight also and exercise daily. I had to accept exercise would be part of my life forever if I wanted to beat this.
Coach Vicky
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