Ringworm drug for dogs (Fenbendazole) might also cure cancer
Comments
-
Was this article on ivermectin previously posted?
https://www.ncbi.nlm.nih.gov/pubmed/29511601
Click on free link to full article near the bottom. Lots of information there. An excerpt below:
Though not named as ivermectin, avermectin IB1 showed the ability to reduce tumor growth in vivo by 50% at day 5 at dose of 1 mg/kg (HED 81 μg/kg) in SHK male mice bearing a solid Ehrlich carcinoma. In addition, at the same dose it inhibits the growth of the carcinoma cell line 755 (C57/BL6 male mice), and the tumor growth inhibition value reached a maximum when avermectin B1 was injected on day 3 after tumor inoculation. Based on the fact that ivermectin inhibits multidrug resistance in tumors, avermectin IB1 was tested with vincristine in the Ehrlich carcinoma, with results indicating that the antitumor effect of vincristine is greatly increased when avermectin 1B1 is administered after vincristine [40]. No further studies have exploited the anti-MDR effect of ivermectin. Nevertheless, the search for novel strategies and/or schedule optimization of MDR inhibitors continues [41], which suggests that there is still room for investigating ivermectin roles in reversing or preventing the development of the MDR phenotype.
0 -
Frisky, 18 mg seems to be a very low dosis, Husband said 149 mg/85 lts water. 18 mg can repeat 15 days after if were neccesary. 6 month to a year for maintenance
0 -
LD50 is 25mg/kg in mices. Assuming a mouse weighs 100 grams ...? about 200 mgs maybe is a dangerous dosis for human... am I right?
0 -
Above shows a 50% reduction in tumor growth when administered at a human equivalent dosage of 81ug/kg. That would work out to 5.27 mg dose for an 85kg individual. So that suggests the 6 mg dosage for parasites is in the right ballpark for 50% reduction in growth rate.
0 -
These studies show more than a 50% reduction in tumor volumes after ivermectin treatment, which varied from 10 to 42 days of treatment by either oral, intraperitoneal or intratumoral routes (more commonly intraperitoneal). The median dose employed was 5 mg/kg (2.4-40 mg/kg), which is equivalent to 0.40 mg/kg in humans, a dose below to the highest dose safely used in human subjects evaluated so far (2 mg/kg) (Table 1). Thus, the in vitro and in vivo results with ivermectin strongly suggest that its antitumor effects in cancer patients can be achieved at feasible doses.
Conclusions
The recognition that drug repositioning is a clever opportunity to accelerate the development of cancer drugs is increasing. So far, at least 235 clinically-approved, non-cancer drugs have proven antitumor activity either in vitro, in vivo, or even clinically. Among these, ivermectin, an antiparasitic compound of wide use in veterinary and human medicine, is clearly a strong candidate for repositioning, based on the fact that i) it is very safe, causing almost no side-effects other than those caused by the immune and inflammatory responses against the parasite in infected patients, and ii) it has proven antitumor activity in preclinical studies. On the other hand, it is now evident that the use of very selective "unitargeted" drugs is commonly associated to early development of resistance by cancer cells, hence the use of "dirty" or "multitargeted" drugs is important to explore. In this sense, ivermectin has this potential as it modulates several targets such as the multidrug resistance protein (MDR), the Akt/mTOR and WNT-TCF pathways, the purinergic receptors, the PAK-1 protein, certain cancer-related epigenetic deregulators such as SIN3A and SIN3B, RNA helicase activity, while stimulates chloride channel receptors leading to cell hyperpolarization, and down-regulates stemness genes to preferentially target cancer stem-cell like population, at least in breast cancer. Importantly, the in vitro and in vivo antitumor activities of ivermectin are achieved at concentrations that can be clinically reachable based on the human pharmacokinetic studies done in healthy and parasited patients. Thus, existing information on ivermectin could allow its rapid move into clinical trials for cancer patients.
0 -
So on average for someone weighing between 60 and 80 kg would be something like 1/2 tablet of 6 mgs per day for a month and evaluate results ...?
0 -
That sounds pretty plausible Yndorian.
0 -
Husband, Sonia...you amaze me! While I was entertaining my friend and neighbor with snacks of steamed Japanese Kabocha squash ( that tastes like chestnuts) and chick peas in spicy tomatoes sauce, you were outdoing yourself with all this useful information about the proper dosage.
Thanks! We're quite a team...and thanks everyone else that's contributing additional info about this medication...together we are unbeatable! Dream team
0 -
What is the reasoning for taking it daily Sonia? I thought it was a one shot story...it that what's recommended for infected people, or is that the protocol recommended as a cancer treatment? She asks as she eats a handful of walnuts....
0 -
It seems most of the research on the agent against cancer used sustained dosages for 10-42 days.
0 -
thanks husband, Sonia, now I understand....
0 -
Frisky, This time it will be trial-error until we find the way that works best for us ... Unfortunately we don't have a Joe Tippens of ivermectin 😊
0 -
Yes...you're absolutely right...Sonia, no established protocol....I wonder is there's a FB group that's been successfully using ivermectin...and what's been working for them
I found these guidelines On Drugs.com, for a single dose...the maximum is 15mg taken once...this is obviously for parasitic treatment, not cancer...
Usual Adult Dose for Onchocerciasis
0.15 mg/kg orally once every 12 months
Patients with heavy ocular infection may require retreatment every 6 months. Retreatment may be considered at intervals as short as 3 months.
Dosage guidelines based on body weight:
45 to 64 kg: 9 mg orally one time
65 to 84 kg: 12 mg orally one time
85 kg or more: 0.15 mg/kg orally one timeUsual Adult Dose for Strongyloidiasis
0.2 mg/kg orally once
In immunocompromised (including HIV) patients, the treatment of strongyloidiasis may be refractory requiring repeated treatment (i.e., every 2 weeks) and suppressive therapy (i.e., once a month), although well-controlled studies are not available. Cure may not be achievable in these patients.
Dosage guidelines based on body weight:
36 to 50 kg: 9 mg orally one time
51 to 65 kg: 12 mg orally one time
66 to 79 kg: 15 mg orally one time
80 kg or more: 0.2 mg/kg orally one timeA generous soul named Roberta, send me these specifications....which seem to match the ones above...
Hi Mina and I've copied the dosage information for different usages below. Not sure now whether this is actually useful but hopefully it helps.
Chronic Strongyloides infection
By mouth
- For Adult
200 micrograms/kg daily for 2 days.
Onchocerciasis
By mouth
- For Adult
150 micrograms/kg for 1 dose, retreatment at intervals of 6 to 12 months, depending on symptoms, must be given until the adult worms die out.
Scabies, in combination with topical drugs, for the treatment of hyperkeratotic (crusted or 'Norwegian') scabies that does not respond to topical treatment alone
By mouth
- For Adult
200 micrograms/kg for 1 dose, further doses of 200 micrograms/kg may be required.
0 - For Adult
-
When that woman told me that in Paraguay they take this drug for cancer, it didn't occur to me to ask her the dose ... Silly of me!
0 -
Ivermectin looks very interesting. I read a couple of the links posted here and one said that it acts upon the parasites by making the cell membrane permeable - and I think that would make sense as to why it is powerful when combined with chemo. But it also seems to have anti-tumor properties on its own.
I also found this link in Google, a caution about overdoing the dosage: "ENCEPHALOPATHY DUE TO PROLONGED MISUSE OF IVERMECTIN (STROMECTOL ®) AFTER SCABIES INFECTION."
https://www.antigifcentrum.be/sites/default/files/imce/Poster_Ivermectin_vs03b_2014.pdf
santabarbarian - I have about the same outlook about "my cancer". They are my own cells misbehaving (or, behaving like a parasite without actually being one). I even talk to them like you do! When I first got my biopsy results, I "talked" to them like I would a child and said "Now, you have to stop doing this, it is not healthy for any of us. I need you to calm down." Now, sometimes I get very stern and say I DO NOT CONSENT TO THIS CANCER :-D or in a mellow mood I just visualize them exploding and disappearing but in a sort of pleasant way like a fireworks display. I don't want them to fear death, I want them to embrace it (only their own, not mine, of course). Glad to not be the only one feeling this way.
Not sure how well they "hear" me but it feels like doing affirmations. It also feels like I have some control - this is MY body not something from outside attacking me, so maybe by owning it, I can influence the process this way, even if just a little. Not that I reasoned this out at first, it was just how I felt - like, they are my cells, they are just confused or got on the wrong track.
Anyway...got a phone call today with good news about my scan! As I posted elsewhere - all clear with just a note about my thyroid being enlarged (but no uptake). MO wants an ultrasound so I'll be going for that, but given my history, I'm not too worried.
Hoping for good news for everyone waiting and that all of us find the path to effective treatment and (dare I say it) the CURE, may it come soon.
0 -
Congrats Olma! That is great news.
0 -
Olma, congratulations on the great scan results!
Both you and Santa intuitive understanding and relationship with your bodies is actually correct...cancer cells are part of us, because our bodies are in reality made mostly of non human material...our so called immune system is made out pounds and pounds of batteria...there are no real barriers between the inside and outside...because we eat, drink, and breathe what's out there...its just a balancing act between good and bad influences that create an environment in which various disease like conditions may thrive. Parasites, yeast and fungi are a part of us, as well, but kept in check under the right conditions...
However, it seems that our lifestyles are making us increasingly sick. Right now, 1in 2 will be diagnosed in their lifetime..I venture to say that the other half are also sick but might never find out before they die of other causes such as heart disease...
Here's How Many Cells in Your Body Aren't Actually Human
They found that for a man between 20 and 30 years old, with a weight of about 70 kg (154 pounds) and a height of 170 cm (about 5'7) - they call him the 'reference man' - there would be about 39 trillion bacterial cells living among 30 trillion human cells.
This gives us a ratio of about 1.3:1 - almost equal parts human to microbe.
There are other scientists that believe that microbial cells outnumber human cells in your body by a ratio of around 10:1.
So, there you have it...the human body in all it's glory! She says as she drink a glass of longbrewed, dark as the night, chaga tea...
PS: this could be a trick of my imagination, BUT, since I started taking the 4mg packets of the FZ—today was my second day—I’m feeling “normal” more energy and stamina than usual...you guys are the only one that would know what I mean...
0 -
Congratulations Olma for you good scan results.. I had my brain MRI yesterday and I've heard NOTHING. Amazing. Has anyone gone back to the facility where they had the scans and demand (nicely) their scan results?
You can purchase ivermectin on Amazon
0 -
snooky - no, never done that. In fact, I always ask radiology to mail me a copy of the report and they never do. I have to get the copies from my onc. In April it was 2 weeks before i saw the onc and I just put it out of mind until I saw her. Was less anxious then, than I was this time. This time, she made sure our appt was right after the scan. I think I only got the call today because of the thyroid issue.
Frisky, very interesting article there. Food for thought.
0 -
Yay Olma!!! Wonderful news!
Snooky, I did. I called the MRI place and asked for them to send me the report, politely reminding them that legally I have the right to it.\.
If they would have hesitated, I would have become less nice, but they did not object. We ALL have a legal right to our results upon demand. Now I ask to speak to the MD in the house before I leave my mammo for the instant result.
0 -
Snooky,
I routinely go back the next day and ask for a copy of the report. Within 24 hrs, they should have it. Never had a problem getting it.
0 -
A while back, I saved the article linked below -- why, I don't know, but interestingly, it's another veterinary drug that seems to have some effect on breast cancer stem cells. Passing it along for what it's worth --
https://www.spandidos-publications.com/ijo/48/3/11...
Bev
0 -
OLMA CONGRATS!!!!! So happy for you.
The WNT pathway is blocked with Dipyridamole, Niclosamide and Asprin. The WNT pathway encourages bone mets in Breast Cancer>>> or some have said that are making metro maps for ER+ HER2- breast cancer...yet in the article bev posted it says
exhibited a potent antitumor activity against several cancers including myeloma (17), glioblastoma (15), colon cancer (18) and lung cancer (19) as a selective WNT pathway inhibitor.
And as far as for breast cancer:
Although the WNT signaling pathway is important for cell proliferation and differentiation, cell movement and polarity, and maintenance of self-renewal in CSCs (20), whether pharmacologic blocking of the WNT signaling pathway with PP in breast cancer could provide therapeutic possibility by inhibiting breast cancer stem cells (BCSCs) remains to be elucidated.
So we have to wonder do we need to block this pathway?
The other thing that I find curious...is that Joe Tippens and Jane both had Lung Cancer.....I am wondering if that is just easier to treat than breast cancer? I feel like BC seems to have so many more variables.
0 -
NY Times...what timing....can't make this sht up!! THIS IS MAJOR NEWS FOLKS!! For years they've been jailing the oncologists that were curing people based on the fungal understanding of the causes of cancer....my buddy MO Simoncini must be laughing his head off...it looks as if, some researchers are finally waking up, coming out of their deep sleep, and seeing things as they are...
In the Pancreas, Common Fungi May Drive Cancer
A new study found that certain fungi can settle in the pancreas, where they spur the growth of tumors.
By now, you've probably heard that your body is teeming with bacteria. Some 100 trillion of them live on your skin, in your mouth and in the coils of your intestines. Some protect against infections and help you digest food, while others can make you seriously ill.
Fungi, viruses and protozoa call your body their home, too. Your fungal residents are less numerous than your bacteria by orders of magnitude, but as researchers are learning, these overlooked organisms play an important physiological role — and when their numbers get out of whack, they can modify your immune system and even influence the development of cancer.
A new study, published Wednesday in the journal Nature, found that fungi can make their way deep into the pancreas, which sits behind your stomach and secretes digestive enzymes into your small intestine. Etc etc...( actually, there's no place where a fungus can't penetrate and thrive, including our brains)
The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL
Here we show that fungi migrate from the gut lumen
to the pancreas, and that this is implicated in the pathogenesis
of PDA. PDA tumours in humansand mouse models of this
cancerdisplayed an increase in fungi of about 3,000-fold compared
to normal pancreatic tissue. The composition of the mycobiome of
PDA tumours was distinct from that of the gut or normal pancreas
on the basis of alpha- and beta-diversity indices. Specifically, the
fungal community that infiltrated PDA tumours was markedly
enriched for Malassezia spp. in both mice and humans. Ablation
of the mycobiome was protective against tumour growth in slowly
progressive and invasive models of PDA, and repopulation with
a Malassezia species—but not species in the genera Candida,
Saccharomyces or Aspergillus—accelerated oncogenesis. ( which means we're all fkd because our food supply is contaminated with these mycotoxins, have you ever asked yourself why no one wants to import our food? )
0 -
Good morning everyone. First, Olma, huge congratulations, you are on a very good path! Secondly, dear Snooky, call them. When I wait for MRI results I call 2-3 times a day. Usually they have results very quickly but do not hurry to send them.
As I log-in only from time to time, it is hard for me to catch up regarding FenBen and "probably-to-be-taken-ivermectin"... has anyone already a "summary" in their heads how to combine these two protocols? Are they compatible? I mean for FenBen we know it is 220 mg/day/3-times-a-week or more, as it does not load organs too much and we have a lot of good examples (many Joes), and for ivermectin we know only dosages for parasites but anti-C dosage is not quite clear, but now we think it is 6 mg/day for one month? I am sorry, I know such questions are annoying... but I love summaries.
Saulius
0 -
Dear Saulius,
Because we lack a protocol, and in view of what my gut tells me, I'm going to start taking this medication as an anti-parasitic treatment. Then wait for results, if none are seen, I would than consider a longer approach. My compromised liver is the main reason for this sensible approach.
But first, I'm going to continue the FZ at a higher dose, and concurrently the COC protocol, as I'm doing, and give that a chance to work. Because, like you've wisely stated, we don't have a clear idea of how to use the invermectin.
I've done a lot of studying on how mycotoxins affect us and control our environment. Now, the results of that study published in Nature are confirming my worst fears...so I have to rethink my whole strategy.Powerful, anti fungal medication would be in order, but like chemo, those meds are extremely toxic...and not effective when the contamination is systemic, thus the idea of “starving” cancer starts to make a lot of sense...but will the COC protocol be enough? I think it depends on how big is the infestation and the organs involved.
0 -
I was searching for alternative treatments for my Mother-in-law and discovered Joe Tippen's fenben protocol, Jane McLelland's "How to Starve Cancer", the COC protocol, and many articles/studies about repurposing drugs. I came across this thread and joined the site to see how others are implementing and doing with adding the dewormer plus any alternatives as a part of their treatment. This is my first post.
My Mother-in-law has stage IV breast cancer which spread to her lymph nodes, rib bone, hip bone, her pelvis, and her liver. She is on taxol and letrozole and I convinced her to try Joe's treatment.
However, as I read more, we decided to swap out the products he uses for others and to add more medications, supplements, and to change her diet.
She is now taking:
-Happy Healing Trio 4 days a week and taking three days off. It has 500 mg fenbendazole, 144 mg pyrantel pamoate, and 50 mg praziquantel (I have read that this enhances taxol). I am looking into having her alternate between this and Doxycycline. I am also reading about Vitamin C infusions during the Doxy cycle. We must learn more.
-1 Rootology soy-free vitamin E every day.
-2 Theracumin HP every day.
-EPA/DHA every day.
-25 mg Bluebird Botanics THC free CBD oil sublingually every day.
-1000 mg Metformin which she recently began to take every day. I have read that it can be increased and she will talk to her doctors about this.
-500 mg Berberine every day. We have read that she should take a break every two months?
-81 mg Aspirin every day.
-1020 mg Best Naturals IP-6 + 4000 mg myo-inositol every day.
-1 Nutracology Super Artemisinin (180 artemisinin, 20 mg sweet wormwood oil) every day.
She has switched to a low carb (but not keto) diet and she is now drinking green tea throughout the day. She has also added more cinnamon, saffron, turmeric, ginger, garlic, onion, various mushrooms, fresh lemon, raw ACV, fermented foods, avocado, berries, greens and non-starchy veggies, some legumes and starches such as kabocha, MCT oil, more eggs and fish over other meat in her diet.
Recently, I have been reading about hydroxychloroquine, it blocking the autophagy pathway, and how it works synergistically with Artemisinin. I am looking for interactions with her medications and supplements. If there are none, we will ask her doctor to prescribe that too.
We also want to add a statin but will talk to her doctors to make sure that they do not negatively interact with her conventional treatments or any of the supplements and repurposed drugs.
We have also discovered Ivermectin from this thread and she may add it in the future.
I will report back as she continues with this, if she makes any changes, if she makes progress, and I will also return to learn more from everyone. I wish everyone on here well. I thank you for sharing what you learn, your experiences and feelings, and for providing a supportive community for women with breast cancer and their loved ones.
0 -
Dear Frisky, I beliefe FenBen+COC+Ivermectin should at least do something. Your next scans will be very interesting, maybe you already should be packing for round-the-world trip (just want to cheer you up and to encourage)! And... so you have already decided to go for Ivermectin 6 mg/day for 30 days before next scan? Or you will go for one dose/month (what dose?) approach also before next scan? I try to have the whole picture as I also consider everything very carefully but "if something" we might be trying these protocols too... Thank you a lot for all your and other's input. The study that you cited from NYT is scandalous (in a way that everyone was laughing at such things), to say the least. I want to see what other "serious" guys have to comment on that...
0 -
Good morning everyone!
iulia: Thank you for sharing your protocol! It seems to be a great plan. We will be waiting for news of how your MIL is doing. Hugs!
Frisky, I guess it shouldn't be so hard for a doctor to prescribe an antifungal ...
I'll comment later on something that I have in mind, now I don't have time ... 😊
0 -
Julia welcome so nice you doing that research for your mother in law.
You mentioned she is on Letrozole...some of the things she is taking interact with that (not in a good way) you should pop over to the https://community.breastcancer.org/forum/8/topics/... thread and check it out.
I am wondering why she takes Metformin and Berberine? Berberine is basically the same thing?
Also I see that she is taking 3 different types of de-worming medications...has she checked her liver enzyme numbers since she has been taking all that?? If she has tumors in liver her liver is already compromised all de-worming meds can be taxing on our liver.
0
