Ringworm drug for dogs (Fenbendazole) might also cure cancer
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JFL , sorry about being off the grid part. I know how strong you feel about being on some treatment, and they have been working well for you, because you're not suffering any major collateral damage. No chemo brain to speak of.
I admire your inner strength and certainty about the course of action you've been taking. May the unexpected happen, and similarly to Denny and Goldie, mayyou greatly and permanently benefit from the capecitabine.
I did ask my own Mo about going back on the capecitabine, the other day, he said absolutely not....
Why not add the FenBen protocol at this time? The SE are non existent, and the outcome, when it works well worth the trouble. Don't you think?
Joe and all the people that are now cancer free, have already conducted the clinical trials for us. Don't we all wish the traditional treatments had similar rate of success?
Yndorian, I second JFL, your English is not only great, but I find your contributions extremely valuable. I used to take Lugol's solution drops and eat hizijki seaweed, and that's actually what I need right now, to physically get out of my funk...when my melancholic streak predominates it blocks my creativity and only melodramatic nonsense comes out....
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Hi Frisky and all! Sorry I cannot post often, but I do follow the most part of the thread. Frisky , your frustration about hospitals and doctors sound so familiar. I don’t trust doctors at all!!!. That’s why I prefer FZ, and I believe in it. I understand you and you are allowed to feel that way, but it’s true ,it doesn’t help .
Love and hugs to all
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thank you Blueshine....it's so important to know that I'm not the only one that feels that way...
May Fenben, like a knight in shining armor, come to our rescue and free us all from our predicaments....wouldn't that be just amazing!
It's almost inconceivable, the type of happiness and freedom we would all feel...it would beat just about everything I had experienced before, that I thought was grand...to be health again!
No fatigue, no nausea, no aches and pains, no worries, no doctors, hospitals and tests...to plan and live as free individuals again. Most of all: to reap the rewards of a life well-lived....I'll drink to that on this 4th of July
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Frisy, picking our poison indeed, since we will most likely be on some sort of treatment for the rest of our lives. Glad there won't be any hair loss. I lost every bit of hair when I did chemo in 2008, entire body, and I mean entire, smooth as a baby's butt! The X pills cause lower immune system, I think most treatment does, and then thera are those the affect the heart. Had to chuckle at the deadly concentration camps and Soylent Green. As for living in the moment, it's what I do, and I'm pretty sure I will be here tomorrow, and next week even! Why is your MO so against trying X again?
Y, your English is fine and I have no trouble trying to figure out what you are trying to say. And hi! Look how beautiful you are. Always nice to put a face to a name.
Mouse, no problems. I think we all have memory issues. True story-my DH calls me Scarecrow, as in I haven't got a brain. My entire family jumped on this one. Everytime I do something or forget something, I'm asked if I need more straw. A bale? Truck load? Etc.
JFL, I don't let my MO tell me what treatment to take, he gives me options and I make the decision. He always tells me that this is my boat and I'm the captain.
Sorry to have been MIA, still not feeling well. I did FZ last week, and took my last X pill (2 weeks on/1 week off) Supposed to start my FZ today, week 6 or 7, I forgot, but I think I'm going to hold off until I get my next labs and I see my onc on the 15th, or if I notice a difference with the Milk Thistle. I'm still running a low grade fever, but not constantly, and urine still has strong odor. Will get my Milk Thistle today and crossing my fingers it helps.
OK, WHO ALL IS ON THE FZ TRAIN AND FOR HOW LONG.....if you remember...LOL.
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Hi ya, Goldie. This thurs. I start week 10!!!! Go back to the chemo chair this morning. Have not been on Taxol for four weeks because of doing Radiation.
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Goldie...It will be 2 months of FZ for me today....my MO would say that since the cancer progressed to the liver, X is no good for me....my perspective instead is that none of the medications had to have worked for a 2cm tumor to have developed...they take a while to get that size...
he said yes to Y90 down the line if Doxil fails....but we all know ALL these medications sooner or later will fail, otherwise none of us would be on these boards praying for each other...
Snooky may today's infusion be easy on you and deadly to the cancer cells....may FZ bring the enemy soon to its knees....
Goldie...do you think you might have high insulin levels? I noticed my pee started smelling lately, urine analysis indicated no infections or problems, but the blood test indicates hi uric acid in the blood. I'm not sure what's causing it, but I'm severely cutting back on my carbs, just in case
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Goldie: thank you! That picture was taken a couple of years ago. Now I look like that girl's mother. This is life!
To all of you who are in chemo or another treatment, I wish you the best result with the less SE!
HUGS
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Apparently, these are the causes of uric acid in the blood...and of course, poisons from the medications are the likely culprit...my kidney are finding it hard to excrete them..
As anyone dealt with this issue before? how? I like my kidneys....how do I keep them healthy short of not taking themedications?
- Primary hyperuricemia
- Increased production of uric acid from purine
- Your kidneys cannot get rid of the uric acid in your blood, resulting in high levels
- Secondary hyperuricemia
- Certain cancers, or chemotherapy agents may cause an increased turnover rate of cell death. This is usually due to chemotherapy, but high uric acid levels can occur before chemotherapy is administered.
- After chemotherapy, there is often a rapid amount of cellular destruction, and tumor lysis syndrome may occur. You may be at risk for tumor lysis syndrome if you receive chemotherapy for certain types of leukemia, lymphoma, or multiple myeloma, if there is a large amount of disease present.
- Kidney disease - this may cause you to not be able to clear the uric acid out of your system, thus causing hyperuricemia.
- Medications - can cause increased levels of uric acid in the blood
- Endocrine or metabolic conditions -certain forms of diabetes, or acidosis can cause hyperuricemia
- Elevated uric acid levels may produce kidney problems, or none at all. People may live many years with elevated uric acid levels, and they do not develop gout or gouty arthritis (arthritis means "joint inflammation"). Only about 20% of people with elevated uric acid levels ever develop gout, and some people with gout do not have significantly elevated uric acid levels in their blood
0 - Primary hyperuricemia
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I had kidney failure 8 years ago. I got ahead thanks to a chinese medicine treatment. Herbs, acupuncture and moxibustion. It took a few months but my kidneys returned to normal
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that’s great to hear Yndorian....I’m going to research further what those herbs are from my acupuncturist
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Hi all just checking in...nothing really to aid. (Frisky, I'll research uric acid when my brain feels like thinking again,}
So, saw Onc before my chemo. He said that my labs were good like normal (liver nothing unusual with results) He knew that I had just come from Radiation last week and was barely functioning for last three days.
Anyways, I guess he knew what" death warmed over looked like" and said would you like more time for radiation recovery, we can wait a week. It surprised me. But hey, I was right there so I said no lets get it done.
Think of all of you guys....it's a great comfort knowing you are all out there. I'm rambling. Going to try to sleep.
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Goldie, your MO has a great attitude - that you are the captain of the ship. Not everyone can say that. I have a great, open-minded MO now who thinks outside the box and listens to all of my questions and considers all of my potential ideas I throw out about future treatments. My previous MO was the opposite. Did not like to be questioned. Never went outside of the box when it came to breast cancer treatment plans. It seems to be the experts in the sub-specialty who are comfortable thinking outside the box. The non-experts don't have the confidence, comfort level or experience to veer outside the lanes of the standard of care.
I came across this abstract about a woman who developed acute hepatitis following self-administration of fenbendazole. This woman took it for lyme disease.https://www.acmt.net/_Library/2017_ASM_Abstracts/A...
Frisky, I know that high uric acid results from the kidneys being unable to properly filter the blood. However, I don't have direct experience with it. I hope you can figure out what is going on.
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JFL, it's obvious from the dates of the blood tests going back to more than 9 months ago, that the problem was created by the chemotherapy capecitabine. My kidneys were unable to clear the toxicity of that medication and months later my kidneys haven't recovered yet from that poisoning..
And now I'm supposed to add more toxins with Doxil?
What's more important in my life: working kidneys or Doxil?
I think the answer is obvious, but unlike your MO's, mine won't like explaining how he plans on reconcile this problem...I will nonetheless ask him how he plans to protect my kidneys from further deterioration
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Frisky, it is scary, we are definitely in an awful catch 22 with treatments versus side effects from treatments. At the end of the day, like Goldie's doctors says, you are the captain of your ship and you can decide what you feel comfortable taking and what you do not.
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JFL, I have been tested for hepatitus, it came back negative. The other thing my mo says is that we treat the patient, not the cancer. Meaning, altho my markers continue to rise, I still feel great. I have no pain, never have.
Frisky, what dose of X were you on?
Snooky, please rest. It will make you feel so much better. I don't care if you take a 3 hour nap every day!
I had a long nap this afternoon, DH woke me up at 6 and we went to bed. So here I am at 10 pm (AZ time) wide awake.
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Goldie I was on 4/4 one week on and off but I lowered it myself to 3/3 when the fatigue became unbearable and h&f started peeling....
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Frisky, I started out on 4/4, 2 weeks on, 1 week off. I had double over cramps, explosive D. I told my DH, I am not gonna do this, I'd rather die. MO dropped it to 3/3, I got a horrible rash all over my body. So then we dropped to 4 and worked up to 5. So I have been on 5 for quite some time. He also told me that if we move on to other things, and they fail, I can try X again. I no longer have fatigue from the drug. Not sure when that wore off
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I got my Milk Thistle yesterday and have take 2 pills so far and I have to say, I feel pretty darn good. Good it really be working that quick?
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Goldie, nothing works that fast, but it will definitely help support your liver over time...I’m so very happy that capecitabine has been working for you so well for all these years. You’ve been my role model...truly!
I did a lot of reading last night and it’s all clear now. My foul smelling urine, high uric acid in the blood, and painful conditions in my right arm and shoulders that are rendering me incapacitated, all point to kidneys malfunction and gout!
There are many reasons for this condition, but the most obvious one is that I’ve been on various medications for the last 5 years and they’ve been taking a toll on my kidneys and liver.
This morning I wrote my MO and requested a postponement of my first infusion, till my kidney functions are restored. I hope he agrees....we'll see....stay tuned...I’m hoping it doesn’t turn into a bumpy ride....
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Frisky, one of the things that I think are in Goldie's favor is her diet! She's written here what she eats, and if I'm not mistaken, she's said she and DH have a garden business (she stated she canned corn) so in effect the food she eats is still brimming with goodness! Because it's so fresh. I also think that I remember she said it's all organic.
Frisky, I copied this from Joe's page.....to warm your heart thinking about one of your hero's.
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Frisky: as far as I know, doxil is metabolized mostly by the liver, not by the kidneys as taxol. I'm wondering if a few days of an enzymatic fruits diet can help you with the urea cleanning. No bananas and no oranges, because they aren't good for liver. Just green apples, pineapples, kiwis, crawnberries, you know. The acid ones
I think that your kidneys are still working but having a hard work. When I had kidneys failure my urine was clear like water, they wasn't filtering anything.
Don't forget that we are taking fb wich is a dewormer, even if we take it for another reason. Died worms releases ammonia, and the liver converts it in urea, so maybe you should take a break of fb too. Just a thought
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Thank you Yndorian for your suggestions. I have already embarked on drinking massive amounts of clean water with freshly squeezed lime juice, organic apples too...the high uric acid levels started 9 months ago, so I doubt it's the FZ simply because the dose is so small. I fear, instead, that it can't possibly work, due to the small amount indicated vs the size of my body.
in clinical trials this Chinese herb T. Bellerica standardized extracts 500mg twice daily, was 60% as effective as the prescription drugs in lowering uric acids levels, without the SE. So I ordered it.
A nurse called me to discuss the situation, I tried to make my case for a week's postponement while I worked hard at eliminating some of the poisons already there. I'm not sure how it will turn out...I might have to accept to be infused on Monday
But I'll be packing and leaving for a small cabin up in the Catskills mountains tomorrow morning...will continue detoxing fromover there...
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Frisky, the Catskill Mountains sounds lovely to get a good time away from all this sh%@$t. Have fun! HUGS
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Frisky, my urine doesn't smell as bad as it has been. Enjoy your trip!
Not sure how much I will be posting. Without going into a bunch of detail, my DD has 75%-80% chance of having Renal Cell Carcinoma. In March, she went into ER, she lives in the Virgin Islands. She had ectopic pregnancy, huge fibroids pressing on her fallopian tubes, which cased internal bleeding. I had to fly out there the day after she had surgery and stay until she was well enough to manage without me, about 10 days. Surgery in the VI is not the best place! They literally cut her from the top of her pubic bone, up and around her belly button. Then she was allergic to adhesive on the tape, which blistered and was very hard to remove. She went to Michigan to get the rest of the fibroids removed and during her surgery in VI, surgeon told her there was a spot on her kidney. She has been in Michigan since 6/1, and missing so much work and she also missed about 6 weeks of work in March. So my heart is just breaking.
Sorry to go off topic
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Goldie I am so sorry to read the news about your daughter. It’s really heart wrenching to look at that big scar...I can feel how much you've suffered and been dealing with.
May all those medical projections prove to be wrong. May she heal quickly and with the best outcome.
Big, warmhugs to both of you....
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Goldie, there are no words! I'll be praying for your DD and for you. Not our kids, it is simply too much! My hearth is with you, hoping this is just a bad moment. HUGHS
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Goldie, my thoughts and prayers are with your DD. Just heart breaking to have to see a child of yours go through this. Harder than dealing with your own situaton, I imagine.
I think "hepatitis" in the article was used in a more general sense. People think of hepatitis in terms of the kind caused by a virus or perhaps alcohol. However, hepatitis simply means inflammation of the liver, regardless of the cause.
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Great article find, thanks. After reading, it appears there's a possibility of hepatotoxicity with fenben, however two things give pause to this conclusion. For one she was taking at least 10 times the potency and two, shealso admitted to taking other unnamed supplements. Also, she denied taking anything when first asked, so one has to wonder what she may also have lied about.
Still, it seems there is the possibility of liver toxicity if a very high dosage is taken, and/or one's liver is especially compromised (perhaps from rapid cancer dieoff that the liver has to clear), and/or the Fenben is combined with other substances known to compromise the liver.
"Two weeks prior, she switched to a formulation with ten times the potency."
After two days of antihistimines and being off the high dose, she was discharged when it returned to normal.
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Sending you and your daughter the best of wishes for a swift recovery. You sure could use some good news and good times. Hopefully the care in MI is much better.
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FYI; A promising new study shows effectiveness of Fenben with melanoma and breast cancer ...was just published this June.
Article
Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells. Molecules 2019, 24(11), 2152. Mrkvova, Z. et al."Our findings have several important implications. Benzimidazole derivatives ABZ and FBZ (Fenben) stimulate the activity of p53 in malignant melanoma and breast cancer cells overexpressing MdmX. Our data provide the first evidence that this enhancement occurs, at least in part, through MdmX and Mdm2 downregulation. This points out the significance of MdmX in p53 regulation in tumors that overexpress this essential negative p53 regulator, such as the majority of malignant melanomas. Both ABZ and FBZ induce a disruption of microtubules, DNA damage, cell cycle arrest in G2/M, and morphological features of mitotic catastrophe. These findings could lead to new perspectives for the repurposing of these anthelmintics, which are already approved for human treatment, for example, for therapy of the tumors overexpressing the negative p53 regulators Mdm2 and MdmX, including malignant melanoma."
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