Ringworm drug for dogs (Fenbendazole) might also cure cancer
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All I am saying is that people should check their supplements against what type of drugs they are taking and make sure it doesn't impact the drugs they are on. Nicole started a thread for people taking ibrance and letrozole and there are several common supplements that were found to impact the effectiveness of the drugs.
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Simone great point because some of us are talking about the supplements with certain Chemo, some of us about meds like Ibrance, some of us are hormone positive and some are not hormone positive and maybe the antioxidants wont/will effect those things differently?
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exactly, just be careful. What works for one person may not be good for another.
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You are absolutely right, the interactions with the drugs that each one takes is another subject. My previous comment was related to antioxidants versus c.a, I don't know anything about antioxidants versus oncological drugs
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Nasty CANCER!!!! It's just so evil trying to make it so confusing when we find things that may help us beat this!!! UGHHH Just gotta rebuke that nasty evil cancer!!!! AMEN
Rant over.
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May we all offer up prayers to Lita57 who has recently passed on from this reality. She's happy now and is in no pain.
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Amen 🌹
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so sorry to hear about Lita's passing. She fought hard, but I believe she was very peaceful toward the end. May she rest in the peace of God!
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I didn't know Lita.. sorry she passed. How long did she have Metastatic BC?
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Nichole dear, please be sensitive with the questions that you ask. Lita just passed away and her daughter is on these boards. I doubt they want to think about how long they battled MBC. They need positive emotions right now not negative.
If you feel the need to know simply type Lita57 in the search box and read her story.
This is not intended to offend but we need to offer compassion.
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Her daughter created a thread with a link to her story. I just finished reading it and it was very moving and sad. Cancer sucks.
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Oh my, biggest condolences to her family and everyone who knew her. My heart bleeds with every life lost because of this disease, and also for ignorance of governments and medical establishment...
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Lita's daughter Mica has created a BRILLIANT visual memorial of her mother's experience with cancer. It’s honest and beautiful, just like her mother's voice and insights were. Devoid of sentimentality and disassociations from the reality of how cancer and cancer treatments transform our lives.
Mica's work proves in no uncertain terms, how truly special and talented Lita was. May she Rest In Peace
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I remember the time she went to receive her IV with her Halloween costume, I remember that she enjoyed cooking, I remember the beautiful pine that she planted for herself, and with what care she chose it ... I have followed everything she posted since I entered these tables. I want to share the picture I've posted in her honor. She is lighting her family now from heaven...
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Sonia, Your thoughts and the photo are beautiful. A great tribute to a very great lady.
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Worth a listen--- Nothing Changes until the Emotions Shift. (talking about healing)
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We cannot hear tone when someone types I wanted to hear from you all who knew her ao to hear a little bit of her story...how you got something negative out of me asking how long she fought her battle with MBC I dont know but I'm sorry you did. I only thought it would be nice to hear about her from people that knew her so well. That was all. Sorry
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Nichole, I almost edited my post last night but, I was too tired. I would like to offer you some "motherly advice", and yes I am old enough to be your mother. I see you all over these boards asking similar questions to everyone. Asking every detail about their cancer. The fact that your cancer is stage three seems to be your current obsession. I see you with a notebook (lol) writing down questions and answers in an effort to gather info that help you KNOW how long Ibrance will work, etc. in an effort to see your future. It can't be done, even the Oncologists don't know that answer.
Honey, you just received an excellent report that your Ibrance protocol was working for you! Celebrate that! Don't anticipate the future. Your jumping from thread to thread reading the horrors of MBC is not emotionally healthy. Of course, say you develop a live met, for example, asking about that would be different.
I just don't want to see you burn out by constantly thinking about cancer. Don't let cancer control you like that. Yes, you cannot hear my tone. I wish you could because I am truly trying to help you.
If this offends you, just say so, and I will delete it.
HUGS
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Snooky I am not stage 3...I am stage 4 with bone and liver mets....
you said:
The fact that your cancer is stage three seems to be your current obsession.
I was just diagnosed in April...yea..I guess I am a little (obsessed)..I don't know that I would use that word..but I would say I am concerned and very concerned at that with my diagnosis ...maybe in a year or so I wont be but yea..it's still kind of new.
I see you say you that if I develop a liver met that would be different than you would understand me asking questions...I DO have liver mets...
How can anyone on here discuss SE's , medications, treatments , procedures with others if they don't even know what the other people's cancer is??? (This has nothing to do with the dear sister that just passed away on here) but everything to do with you saying "you see me all over the boards asking questions" of course I am thats what forums are for to discuss things. If you wanted to give me "motherly advice" then why not PM me about it, but ok. I don't think any of this conversation should have been had here if you had an issue with my original post you definitely could have asked me privately how I meant it or talked about with me..I would have gladly edited my post to word my question differently.
Also when I referred to not being able to hear a persons tone. I wasn't talking about your tone... I was referring to you hearing me when I originally asked about the sister that passed.
Edited..forgot to give you HUGS back. (((hugs)))
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A bit off topic, but a follow up on the post I made about high dose melatonin. My wife took 60mg upon waking, and that did not have a negative impact on her sleep, nor make her drowsy during the day. It seems for both of us, a high dose before bedtime, leads to sleeplessness. We will try adding a second high dose later in the day, and see how late in the day she can take it and still have good sleep. I am thinking around 5-6 pm would be the latest, as melatonin has a short life.
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Thanks Husband11! I am only taking 30mg at night for now, does help me sleep very well. I want to work it up to 60mg.
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Slowly incrementing the dosage might be the key. Good to hear you are ok with 30mg at bedtime. Have you tried taking it throughout the day?
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Back to my favorite topic MAGNESIUM!
Snooky, I have been reviewing in depth that article you sent me a while ago...and yes, I know for a fact that magnesium is pivotal to my well being.I was taking 400mg with breakfast and dinner, now I'm adding 400mg with lunch, since I've noticed that my energy drops precipitously and aches and pain increase after lunch. This mineral is key to hundreds of functions, and our food supply is severely depleted of this mineral. Apart from my complimentary doctors, NONE of my 3 MOs have every told me about the importance of magnesium for my overall health...and cancer management....hummm....
Magnesium deficiency and increased inflammation: current perspectives
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC57831...Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis
Magnesium is the fourth most abundant mineral in your body.
It's involved in over 600 cellular reactions, from making DNA to helping your muscles contract (1Trusted Source).
Despite its importance, up to 68% of American adults don't meet the recommended daily intake (2Trusted Source).
Low magnesium levels have been linked to many negative health outcomes, including weakness, depression, high blood pressure and heart disease. I'm adding that it promotes the development of cancer....
Look here...wonder never cease!!
Magnesium and cancer: a dangerous liason.
Author information
Abstract
A complex relationship links magnesium and cancer. The aim of this review is to revisit current knowledge concerning the contribution of magnesium to tumorigenesis, from transformed cells to animal models, and ending with data from human studies. Cultured neoplastic cells tend to accumulate magnesium. High intracellular levels of the cation seem to confer a metabolic advantage to the cells, contribute to alterations of the genome, and promote the acquisition of an immortal phenotype. In magnesium-deficient mice, low magnesium both limits and fosters tumorigenesis, since inhibition of tumor growth at its primary site is observed in the face of increased metastatic colonization. Epidemiological studies identify magnesium deficiency as a risk factor for some types of human cancers. In addition, impaired magnesium homeostasis is reported in cancer patients, and frequently complicates therapy with some anti-cancer drugs. More studies should be undertaken in order to disclose whether a simple and inexpensive intervention to optimize magnesium intake might be helpful in the prevention and treatment of cancer.
MAGNESIUM IN ONCOGENESIS AND IN ANTI-CANCER TREATMENT: INTERACTION WITH MINERALS AND VITAMINS
Mildred S. Seelig, M.D., M.P.H.
Adjunct Professor, Department of Nutrition, School of Public Health, North Carolina University Medical Center, Chapel Hill, N.C.
Magnesium (Mg) deficiency can paradoxically increase the risk of, or protect against oncogenesis.(1) Over 300 enzymes that influence the metabolism of carbohydrate, amino acids, nucleic acids and protein, and ion transport, require Mg.(2,3) Its roles in fatty acid and phospholipid acid metabolism, that affect permeability and stability of membranes, are being elucidated.(4-6) It has been proposed that Mg is central in the cell cycle, and that its deficiency is an important conditioner in precancerous cell transformation.(7-9) In addition, immunocompetence (that eliminates transformed cells) is Mg-dependent.(1,10-12) Mg supplementation of those who are Mg deficient, like chronic alcoholics, might decrease emergence of some malignancies.(13)
Magnesium and cancer: more questions than answers ( not for meee!!)
https://www.ncbi.nlm.nih.gov/books/NBK507261/
The following scenario is feasible. Low Mg promotes oxidative stress and inflammation which generate genetic instability and, therefore, increases the risk of mutations. Since Mg is an essential cofactor in almost all enzymatic systems involved in DNA synthesis and repair, under low Mg availability mutations may become permanent thus generating the so-called "initiated" cell. The persistence of oxidative stress and inflammation together might generate further mutations, which render the cell immortal and self sufficient in terms of proliferation. Some cells might also acquire an invasive, metastatic phenotype and colonize distant organs (Figure 1).
I'm currently taking 30mcg of melatonin one hour before going to bed, I usually wake up around 5am. Have not adjusted yet to daily activities while taking melatonin....it's good to read about your experiences during the day.
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Nichole, I realize that you are stage 4, I meant to type "grade" 3. I appreciate your opinions and perhaps you're right I could've pm'd you. I see that I have offended you. I will delete the post but I do hope that you take some of what I said to heart. I had your well-being in mind.
Friends?
HUGS
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Frisky, what you posted about magnesium is fabulous. I still haven't found a kind of magnesium that doesn't make me run to the bathroom ... I have read that our intestine has a quantity x of magnesium receptors (I suppose it is different for each one) so if we take too much in one shot, what cannot be absorbed goes away in the form of diarrhea. Assuming the receptors are available again to receive more magnesium in an hour or two, the solution is small amount several times per day. At the end of the day you will have more magnesium in your system than if you made 2 large shots.
Thank you for remind me about the importance of magnesium. I will give it a try again. We are lucky to have each other in this thread
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Frisky,
That was an interesting article. The cancer center had me bump up my CA intake. I wonder if I also need to supplement with mg. My mg level is currently normal.
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Sonia and Simone, you might not be depleted as much as I am...so use as much as your body needs. There's an unmistakable increased sense of well-being if your body needs it You're right about ingesting smaller doses. I use magnesium citrate, but magnesium chloride is better. Another way of absorbing magnesium is through the skin. I apply oil of magnesium, obtained from the Dead Sea, to my lower back when the pain increases usually after physical activities, and voila....it dissipates...
My stool is usually perfectly formed, but I supplement also with calcium and vitamin D3 etc etc. I think the conventional ratio of 2CA to 1MG is what's wrong....plus cancer and cancer medications deplete our reserves, but of course this disease presents itself in unique ways.
I only know that today when I took the additional Mg with lunch I was suddenly breathing normally, had more energy, less aches and pains, and managed to prepare a baked pasta casserole with a large variety of roasted vegetables and ragù sauce—that takes forever to put together—effortlessly. Only yesterday, this task would have exhausted me...
Here's updated information on the role Fenbendazole plays.
Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature
https://www.mdpi.com/2072-6694/11/9/1284
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https://www.nature.com/articles/s41598-019-42282-y
Direct and indirect associations between dietary magnesium intake and breast cancer risk.
This study aimed to explore the effect of dietary magnesium intake on breast cancer risk both directly and indirectly via its effect on inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). This case-control study recruited 1050 case patients and 1229 control subjects. Inflammatory marker levels of 322 cases and 322 controls, randomly selected, were measured using ELISA, and data on dietary magnesium intake were collected using a food frequency questionnaire. Multivariable logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI), and path analysis was used to investigate the mediating effect. A higher magnesium intake was associated with a lower breast cancer risk (adjusted OR = 0.80, 95% CI = 0.65, 0.99). A positive association was found between the CRP level and breast cancer risk (adjusted OR = 1.43, 95% CI = 1.02–2.01). However, IL-6 was not found to be associated with breast cancer risk. Path analysis revealed that dietary magnesium affected breast cancer risk both directly and indirectly by influencing the CRP level. The results indicate that a direct negative association and an indirect association through influencing the CRP level were observed between dietary magnesium intake and breast cancer risk.
Associations of intakes of magnesium and calcium and survival among women with breast cancer: results from Western New York Exposures and Breast Cancer (WEB) Study
Meng-Hua Tao,1 Qi Dai,2 Amy E Millen,3 Jing Nie,3 Stephen B Edge,4 Maurizio Trevisan,5 Peter G Shields,6and Jo L Freudenheim3Author information Article notes Copyright and License information DisclaimerThis article has been cited by other articles in PMC.
We found that magnesium intake alone may improve overall survival following breast cancer, and the association may be stronger among those with high Ca:Mg intake ratio.
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For clarity - I am stage 2 by a 1mm only - have been treated as 3. I have been following this thread. Please scroll over if my head summary is of no use to you. To be honest I thought of Lita this morning and here I am writing.
In Australia our oncologists ( well at least those on the GC) have no issue with adding parts of this protocol to both BC and lung cancer. You have to ask them if you can take it - and the answers have been yes sure ( both BC and lung - I dont know benefit). I guess they are on the sideline waiting for numbers to come in.
In terms of getting metformin and statins - those drugs get prescribed on fasting blood sugar levels and lipids - if an error was made for example and the patient was not fasting, but was thought to be fasted for that blood test the levels would be higher and those drugs theoretically would be prescribed. In the face of that and all current evidence doctors here do write up those for BC if asked.
The evidence is sketchy so I may not make much sense. We seem to have
fenbendazole et al vit e and CBD
doxycycline
metformin
statins
celebrex aspirin
as repurposed drugs ( there a few other butvless on them) and they are various trials around them.
Some are clearly working better around key therapies such as radiation in TN and doxy or immunotherapy and fenbendazole. Metformin decreases DNA glycolation the anti ageing industry is all over it. Whether the effects of celebrex and aspirin are different in BC is foggy - aspirin blocks the cyclo-oxygenase pathway high up and it has an effect on platelets non reversible so those with bone marrow issues/and liver issues can not take. Celebrex does not affect platelets but can be prothrombotic long term. Both cause GI upsets - so if are on them take them at full meals. Both block prostaglandins and this where the beneficial effect might be. Some debate around how well is a baby aspirin absorbed.
Then a whole soup of supp. Some are simple supp - not sure they would help unless you have a particular defiency - the problem is few of us get tested - and a western diet is often full of deficiencies - so a quality multivitamin with low or no iron component makes sense. Follow adaptogenic supp from ayuverdic or chinese medicine - curcumin and ashwangandha being ones I like. Follow flavonoids and antioxidants. For my money a lot of the antioxidants are better in natural form than tablets - I think absorption is higher and they are often eaten/prepared to complement each other.
I saw Bergo response with interest. Thank you Salius! My question to him would be - are antioxidantsdetrimental all the time or during a critical period - and what is that critical time? The converse being does he think antioxidants might be of benefit during a particular phase of treatment?
I think one of the many reasons we struggle with treatments is that not only does the drug we use have to be right for the hugely heteregenous BC disease but for that life phase of the disease. The f...ing thing changes and adapts so what we do needs to keep changing. And at the moment we are one step behind because we change on progression. The science world is looking for markers that will allow to change before progression - because we are kinda of just playing catch up. That is why Salius " get to nead and find a way to stay there " was instinctively accurate - find a way to stay ahead. Not easy.
on a lighter note🙂
I like green tea, lemons and mandarins, home made pesto or tapenade or hummus, cabbage, saur kraut, green smoothies, berries, onions of any type,fish. I avoid sugar, bread, dairy that is not cheese, meat, and yes alcohol.
( as an aside someone asked if one could get cancer from a blood transfusion - highly unlikely. we have had a very few world reported (compared to how often it happens) cases of cancer following needle stick injuries but the tumour transfer load there is huge because the intrument had been in the tumour - we ALL have some cancer cells in our bodies - they just get mopped up by the immune system in "cancer free" people - we are now pretty convinced that malignancies are multifactorial but an immunity that fails to guard is one of the main components. Having said we have strong evidence particularly in bowel ca that blood transfusions are immunosuppressive - so best avoided if you can, so are some of the drugs we treat pain with - opioids)
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Wildplaces, great post.
I agree probably multiple factors are needed to grow a cancer.
I have a mutation "of unknown significance" on my TP53. The one they know about that's horrible on TP53 is a mutation that causes Li Fraumeni Syndrome (multiple cancers beginning at a young age), which is why they test for it.
TP53 is related to tumor suppression... possibly my mutation could have a relevance that is not yet known. About 75% of all BC tumors have some ind of TP53 mutation. Obviously if the "brakes" for cancer are not working, then it accelerates.
We all have different cancers, AND our bodies have different genes and mutations, AND different organs are affected (if metastatic) which cause different 'downstream' issues in the body. AND we eat and move around differently. We have different stressors and histories, and different underlying medical conditions.
All this changes the "terrain" of the body.
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