Metastatic Breast Cancer (MBC or Stage IV)

Help progressed to Brain Mets and fighting for the right treatment
Hi All, Been lurking on the stage 4 forum for some time. Now I need help. I live in the UK and attend UCLH where treatment seems to adopt a more cautious approach. Originally on Breast 09 trial but randomised and receive standard of care😢 6 rounds Doxetaxel and H & P. Over 2 years later and progression to Brain Mets. Upper…
Zoom Meet-up for Those With MBC: Place to keep chatting
This is a space held for our Zoom Meetup members to gather in between meetings for updates and support. Join our Virtual Meet-ups! For those with a diagnosis of metastatic breast cancer (MBC; also called stage IV) Register: Mondays at 2:00 PM EST, Tuesdays at 1:00 PM EST, and Wednesdays at 4:00 PM EST Young (45 and under)…
Dealing with Lymphedema w/o surgery?
Hi community. I'm posting since I haven't found a similar case yet. I opted out on surgery and chemo (too late), and it's been a good run for 7 years. The LE came on slowly to rt arm, dr diagnosed. Now its in both feet, then the left breast just swelled in size. No real noticeable discoloration. Has anyone else had LE…
I was just now dx with skin mets
Hi, I've not had good news since forever—since suspected recurrence in August 2023 anyway, looks like I won't be getting any either. I had some red raised places — not bumps, not nodules, that would get red, then go away, etc. that appeared Nov. 23, the same month I was dx with St. IV. PET scan didn't show this. CTs-four…
Wife is starting Xeloda soon
Hi all, My wife was diagnosed with mBC in 2023. She has been through 4-ish lines of treatment, the latest Enhertu. She has felt great with no side effects but it has stopped working after a year. This is next and I’m terrified of the side effects and what living with them will be like for us and our relationship. Can…
Now Enrolling: Cognitive Outcomes & Partner Engagement in Metastatic Breast Cancer Study
Enrollment for Cognitive Outcomes & Partner Engagement in Metastatic Breast Cancer Study at the University of Texas at Austin has started. Through this remote study, we hope to understand how individuals living with metastatic breast cancer, along with their partners, deal with cognitive symptoms during their everyday…
Wife starting Xeloda
Hi. Hope it’s okay to post as a family member/caregiver. We found out yesterday that there has been new tumor growth in my wife’s bones. Very lucky that mets are confined there. Have been reading about Xeloda side effects and now I’m scared. She’s been on Enhertu for a year and had no side effects so this feels like a…
Top Breast Cancer Research at ASCO 2025
Top Breast Cancer Research at ASCO 2025 Dr. Eleonora Teplinsky explains DESTINY-Breast09, ASCENT-04, and SERENA-6. Jun 2, 2025 The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting featured five days of presentations and educational sessions on all types of cancer. Dr. Eleonora Teplinsky, a board-certified…
The Research METAvivor Funds
The Research METAvivor Funds METAvivor President Dr. Kelly Shanahan discusses the research the organization supports. May 16, 2025 By 2030, researchers estimate that about 246,000 people will be living with metastatic breast cancer. METAvivor is the first organization dedicated to raising awareness of, and funding research…
Testing for ESR1 Mutations, Then Switching to Camizestrant Improves Outcomes for HR+ HER2- MBC
Testing for ESR1 Mutations, Then Switching to Camizestrant Improves Outcomes for Metastatic HR+ HER2- Breast Cancer May 31, 2025 After two years of follow-up, the new treatment improved survival and quality of life. Read more…
New Hormonal Therapy Vepdegestrant Promising for Some Metastatic HR+ Breast Cancers
New Hormonal Therapy Vepdegestrant Promising for Some Metastatic HR+ Breast Cancers May 30, 2025 The new medicine offered more benefits than Faslodex. Read more…
Trodelvy and Keytruda as First Treatment for Metastatic TNBC: A New Standard of Care?
Trodelvy and Keytruda as First Treatment for Metastatic TNBC: A New Standard of Care? May 30, 2025 People lived longer without the cancer growing when they received Trodelvy and Keytruda compared to the current standard treatment. Read more…
Enhertu Plus Perjeta: New First-Line Treatment for Metastatic HER2-Positive Breast Cancer?
Enhertu Plus Perjeta: New First-Line Treatment for Metastatic HER2-Positive Breast Cancer? Jun 1, 2025 The combination offered better outcomes than the THP chemo regimen. Read more…
Feeling like an Imposter
Six years ago, at age 46, I was diagnosed with Stage 1B mixed mammary carcinoma, ER+/PR+, HER2- in one breast. I had one surgery - double mastectomy plus bilateral salping-oophorectomy direct to reconstruction. I have a strong family history of breast and ovarian cancer. I did not need radiation and my Oncotype score of 18…
SSDI review with metastatic breast cancer - lose benefits?
I just got a packet of mail from my state disability determination services office, saying that they are reviewing my disability status. I was diagnosed with unnumberable bone-only mets in Feb 2020. I was on Kiquali/letrozole for about 4 years, and now I've sped through Orserdu, piqray, and now, Truqap just in this year.…
Just diagnosed with ILC mets
Hi, all I had ILC back in 2008. Had radical mastectomy on the right breast and prophylactic on the left. Chemo AC→T, radiation and 7 years of Arimidex. 16 years later I am back in the game. Still in discovery phase. Had FDG Pet Scan that shows liver uptake, had endoscopy that shows little spot in the stomach consistent…
De Novo Stage IV
I'm wondering if there is a topic just for de novo Stage IV. I'd like to know how people found out. Did you have symptoms that led you to the doctor for an answer? Was it found out of the blue when you had another issue and how was it found? Are there others like me who have never shown it in your breast but only where it…
Important Stage IV Topics and Links for Stage IV Newbies
Here are some helpful resources if you've just been diagnosed with stage IV breast cancer, also known as metastatic or MBC. Join our free Virtual Support Groups for MBC! All with Metastatic Breast Cancer (MBC; also called stage IV) Register: Mondays at 2:00 PM EST, Tuesdays at 8:30 PM EST and Wednesdays at 4:00 PM EST…
17 years out - Now possible brain mets?
Hi everyone, this site was such a tremendous source of support during my previous experience, but I have not been here in quite a while. I thought I put this part of my life away. I was diagnosed at 38 with TNBC, Stage 2 in 2008. Underwent lumpectomy, chemo and radiation. My port tried to kill me… got infected and put me…
Are you dealing with infections or bandaging during palliative care??
Hi everyone. I'm starting this topic because I haven't found a similar one to help answer questions and offer me advice. I know I'm a rare case managing my own palliative care, in Asia, while under the care of a great doctor who's using both eastern and western medical traditions. I'm on hormone therapy (Tamoxifen then…
Chemo sensitivity test
Hi, I’m in NZ - stage 4 lobular and looking at the tests that tell you what chemo will work. I’ve done Foundation One which my oncologist recommended. I’ve just found out about the Geonostics Exacta Test - snd the Gradient test I’m confused so just wondering if anyone knows what the differences are - or which one is best.…
Should Doctors Regularly Screen for Breast Cancer Brain Metastases?
Should Doctors Regularly Screen for Breast Cancer Brain Metastases? Mar 5, 2025 Research suggests current screening guidelines for brain mets need updating. Read more…
Traveling with MBC - Inspire others with your vacation experiences and tips!
Hi everyone! We have a new content highlight on Traveling With Breast Cancer, and would love you to share your tips, experiences, memories, and advice for those with metastatic breast cancer who are considering traveling, but might not feel well enough, think they don't have the energy, are concerned about risks of travel,…
Beautiful home hospice care story
Hi everyone. I just read this beautiful story written by a daughter whose parent decided to have hospice care at his home. It seems that sharing it would be a positive contribution to those like myself who are nearing the end of their experience with cancer, and thinking about hospice care at home. Here's the link :…
FDA Approves Dato-DXd for advanced-stage HR+, HER2- breast cancer
Psychological reactions to aromatase inhibitors.
I'm sure this has been discussed on other pages but I want to start a thread specifically for this discussion. For the second time, I have had a severe neurological response to Aromatase inhibitors. The first time I was told there is nothing that would help so I quit taking the meds That was 6.5 years ago. I recently had a…
Our treatment histories
Hello, So far, I've been a silent member only, so this is my first post. I have been following many discussions regularly, and found this forum an incredibly helpful and encouraging place. I was wondering if we could have a thread to collect our treatment histories? Which drugs we've been on, how long we've been on each,…
CHEK2 Mutation
I was at my gastroenterologist last week. He passed on the following news adding that this is the first time (praticing over 30 years) that he has ever seen a risk being removed from guidelines. In August of this year, the National Comprehensive Cancer Network (NCCN) guidelines removed the warning that a CHEK2 mutation…
It's OK - No Surgery, No Chemo
Hi Community I haven't found this topic yet, so here's a start (if it's too long, I apologise in advance): I'm in Stg IV with the HER2 cancer growing from the right breast, and first discovered a grape-size lump in Aug 2018. I couldn't get a biopsy until June 2019 (SSA had cut SSI funds), directly before which my PCN said…

Metastatic Breast Cancer (MBC or Stage IV)

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