-
Important links about Genetic Testing
These Breastcancer.org links may offer helpful information: All about Genetic Testing: Genetics as a Risk Factor Genetic Testing as part of your Pathology Report What to do with your genetic test results Variants of Unknown Significance (VUS) Learning about your family background Genetic testing facilities and cost…
-
Tert variant p.E652k aka c1954G>A
I just received my genetic test results and I have the above variant which is known to cause all different types of cancers the most concerning as a micro papillary form of breast cancer. Has anyone else received this and also had multiple biopsies and scans due to an area of concern?
-
CHEK2 Mutation
I was at my gastroenterologist last week. He passed on the following news adding that this is the first time (praticing over 30 years) that he has ever seen a risk being removed from guidelines. In August of this year, the National Comprehensive Cancer Network (NCCN) guidelines removed the warning that a CHEK2 mutation…
-
BRCA2 negative and now positive
Hello, I was first diagnosed in 2015 with early stage IIb. I had genetic testing done at the time and was negative for all mutations including BRCA1 and 2. I had a recurrence in 2022 and I had the Caris test done on the tumor and again no BRCA found. Just within the last month I had a PET scan turn up some swollen lymph…
-
BRCA2 but no family history of breast cancer
So my Mum had peritoneal cancer and found out she had the BRCA2 alteration. That's how I have just found out that I have inherited it through genetic testing. We have no history of breast cancer in the family as far as we know, however the Dr's told my mum that they could see that her cancer had developed from her ovaries…
-
Not Sharing Genetic Risk
Hello I am new here, Our 45-year-old daughter died on May 14th of this year from triple negative breast cancer that metastasized to her brain and though a tumor was removed, it came back immediately and killed her. Unfortunately, family members knew back in 2020 that she should be tested for the RAD51D variant that had…
-
Breast cell line
Hi, I keep reading studies online that refere to "brest cell lines", for example: MDA-MB-231, MDA-MB-468, MCF-7, and T-47D I can't understand what that really mean...if they actually matter, how do i know what cell line i have, if it is even important to know for the therapy choice. Do anybody know what I'm talking about…
-
Breast Cancer After Childbirth and Survival in Women With BRCA Mutation
Breast Cancer After Childbirth and Survival in Women With BRCA Mutation Jul 15, 2024 Does being diagnosed with breast cancer after giving birth affect survival? Read more…
-
Gene BLM pathogenic variant
Anyone with stage 1, grade 1 HR+, HER2- Invasive Ductal Carcinoma with a pathogenic BLM variant? Still waiting for final pathology after lumpectomy. With this genetic variant, a history of eczema & atopic dermatitis and numerous allergies, sensitive skin and hypermobility (connective tissue disorder), I am leaning towards…
-
Genetic Testing Saved My Life
Genetic Testing Saved My Life May 31, 2024 Dr. Brooklyn Olumba explains how discovering she had a BRCA2 mutation led to earlier breast cancer screening and detection. At the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, Dr. Brooklyn Olumba was part of ASCO Voices, a program that gives people in the…
-
Genetic Mutations More Likely in Breast Cancer Found Between Mammograms
Genetic Mutations More Likely in Breast Cancer Found Between Mammograms May 15, 2024 Having a family history of breast cancer and a mutation in any of the five main breast cancer genes may increase the chance that you may discover breast cancer between your routine mammograms. Read more…
-
Lynparza Approved To Treat High-Risk, Early-Stage, HER2-, BRCA+
Lynparza Approved To Treat High-Risk, Early-Stage, HER2-Negative Breast Cancer With BRCA Mutation Mar 13, 2022 The FDA approved Lynparza to treat early-stage, HER2-negative breast cancer with a BRCA1 or BRCA2 mutation and a high risk of recurrence, which also has been previously treated with chemotherapy — either before or…
-
ASCO and SSO Update Genetic Testing Guidelines for People With Breast Cancer
ASCO and SSO Update Genetic Testing Guidelines for People With Breast Cancer Apr 8, 2024 Updated guidelines say anyone age 65 or younger diagnosed with breast cancer should have genetic testing for BRCA1 and BRCA2 mutations. Read more…
-
NBN Genetic Mutation...anyone else?
Hello, I was diagnosed with breast cancer at age 29. Genetic testing was brought up shortly after my diagnosis. I decided against it, at the time, for several reasons...the cancer institute in the city I live does not have a genetic counselor so I would have had to travel 5+ hours for this, no family history of breast…
-
Chemo Sensitivity test
Hi, I’m in NZ - stage 4 lobular snd looking at the tests that tell you what chemo will work. I’ve done Foundation One which my oncologist recommended. I’ve just found out about the Geonostics Exacta Test - snd the Gradient test I’m confused so just wondering if anyone knows what the differences are - or which one is best.…
-
PALB2 mutation
Anyone else get tested for PALB2 gene mutation?
-
Preventive Removal of Ovaries, Fallopian Tubes Linked to Better Survival in BRCA+ Breast Cancer
Preventive Removal of Ovaries, Fallopian Tubes Linked to Better Survival in BRCA-Positive Breast Cancer Oct 25, 2023 Removing the healthy ovaries and fallopian tubes improved survival in women with a BRCA mutation who were diagnosed with breast cancer. Read more…
-
Share your story of Genetic Testing
Dear Members, Would you be willing to share your story about genetic testing? (no pressure, only if you are inspired!) We are interested in the following questions: What led you to doing the testing? What were your results, and what choices have you made based on the findings? Was payment an issue? How have you discussed…
-
BCO Content: Variants of Unknown Significants (VUS)
Check out our new content on Variants of Unknown Significants (VUS)!
-
At-Home Genetic Tests Miss Many Mutations
At-Home Genetic Tests Miss Many Mutations Aug 15, 2023 Genetic tests that you can take at home miss more than 90% of BRCA mutations linked to cancer in people without Ashkenazi Jewish heritage. Read more…
-
CHEK2 Mutations Linked to Hormone Receptor-Positive Cancer Treatment Resistance in Younger Women
-
Has anyone had a VUS for VHL ended up with BC ?
Hi Friends ~ While waiting for my BC diagnostic & pathology reports, I paid to have BRCA 1&2 testing done through Life Labs here in 🇨🇦 which use INVITAE in California (I tested negative for both BRCA 1&2) I then had an additional panel evaluate 47 genes & received the following result. "A VUS, identified in VHL. VHL, Exon…
-
Anyone repeat BRCA2 gene mutation test
I learned through genetic testing after getting diagnosed with IDC that I had the BRCA2 mutation. The genetics counselor said it had to have been passed down from my father or mother and they would have had it passed to them through their parents. My dad died at 47 of a heart attack but my mom died in her 80’s of a…
-
Obesity May Increase Risk Even More for BRCA+
Obesity May Increase Breast Cancer Risk Even More in Women With BRCA Mutations Mar 22, 2023 Obesity may increase breast cancer risk even more in women with a BRCA mutation, who are already a high-risk group. Read more...
-
Breast Cancer Risk Remains High for BRCA+ Women After Age 50
Breast Cancer Risk Remains High for Women With BRCA Mutations After Age 50 Mar 2, 2023 Women with BRCA mutations continue to have a higher risk of breast cancer after age 50. Read more...
-
Anyone with ATM gene variant that decided to have a mastectomy?
Hello everyone. I finished chemo today and now trying to decide between a lumpectomy with radiation or a bilateral mastectomy. I'm seriously thinking about a mastectomy. Would anyone in a similar situation as me be willing to share their feedback on what helped you decide to go for a bilateral mastectomy? How are you…
-
ATM gene mutation and mastectomy?
Hi all, My name is Silvia , I'm 28 years old and I'm from Italy and I was diagnosed with breast cancer HER2+ stage 2 grade 3 Ki67 30% in March 2022. I'm now under treatment with neoadjuvant chemotherapy and my surgery will schedule in October 2022. I was diagnosed last week with ATM gene mutation. Before the genetic test…
-
Certain Gene Mutations Increase Risk in Opposite Breast
Women With Certain Genetic Mutations Have Higher Risk of Cancer in Opposite Breast Jan 31, 2023 Mutations in four genes linked to breast cancer greatly increase cancer risk in the opposite breast. Read more...
-
Medicare and genetic testing
I just was assessed at the high risk breast clinic and one of the recommendations was genetic testing. I'm all for that but I can't find anywhere whether Medicare covers it or now. I'm just wondering if anyone here has experience with that situation? Thank you!
-
Possible BRIP1 mutation, any help is appreciated.
Hi! I hope it's ok I post here, I am very new so apologies if I do this wrong. I know nobody here is a doctor but I'm looking for any advice I can get right now: I semi recently learned my mother has the BRIP1 mutation, her and her cousin got tested after her cousins brother passed from lymphoma (unrelated) I am very…
-
Genetic Testing Decision Making & Barriers Youve Faced?
Hi all, We're looking for members to share their experiences with making decisions regarding getting genetic testing and any barriers you have faced in doing so. If you'd be willing to share your story, could you please post here or send us a PM? Thanks in advance!