Ringworm drug for dogs (Fenbendazole) might also cure cancer
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I really get the need to take action and not wait for the likely never to be done double blind studies on alternative treatments. No one is offering up a cure, so what you are wagering with is the time you have left, in hopes of something much better. My wife takes maitake D extract, metformin, lactoferrin, vitamins, vitamin D, melatonin, at times chaga tea, ahcc, whole maitake, shitake, has taken oil of oregano, I3C, citrus derived pectin, curcumin, tocotrienols and I have undoubtedly forgotten many others she has taken from time to time. She used to see a Naturopath and get vitamin C infusions, along with mistletoe and a number of other expensive add on. We believe she had an allergic reaction to the mistletoe, so she quit altogether with the infusion. That and its also hard to get an IV into her. We try to balance cost, risk and reward. I really hope the dewormer works. It makes me think about the various cancer drugs that are similar to antimalarial drugs, and the work that suggest some basic antimalarial drugs like quinine and synthetic derivatives may work against cancer.
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Husband11 - Dra.Clark always said that cancer is caused by the worm fasciola burskii. If her theory was right, it make me sence that an antimalarian would work against cancer, because malaria is also caused by a worm. All of the herbs and supplements like oregane oil, curcumine, artemisine, included mistletoe are dewormers. I think cancer is a mix of factors, but one of them are the worms, if you kill them, maybe the other factors don't be ables to produce cancer by themselves
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Miao,
Good call not to start tomorrow, but be excited!! This is a whole new drug, incredibly strong!! If it works out we will all be clamoring to get on it!!
So yes, we don't know the side effects of CDK2 inhibition. The CDK4,6i SEs we all know about.
Just remember three things:
1- the body can have a strong reaction that settles down after a month or two on the drug, for sure I had awful fatigue to I-F but then my body adjusted..
2- these are very potent inhibitors, so if its truly awful, I am sure you will be making them dose-reduce. They very probably will be testing enyzmes as you take the meds, making sure the markers in the body are responding as they predict- they want to make sure the kinases are well and truly inhibited
3- It cannot be worse than chemo, gimme a break...
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It would be interesting to know if this new drug also inhibits CDK12, because that would likely make expose your cancer cells to the immune system- will you be taking the drug alone, or with faslodex?
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Cureious.... I wish I could feel your enthusiasm for this drug...but the opposite is true. Maybe because I sense no enthusiasm or excitement in the voices or faces of the people involved either. Instead only deep concerned serious looks and somber tones usually reserved for funerals, or a plunging stock market...
Actually today I had a lovely nurse give me the list of SE, which indicates this medication is quite different from the ibrance I took two years ago, and more like an oral chemotherapy agent. NOT the improved Ibrance my mo sold me on....not at all!
What to expect? Nausea every 12 hours when I take the pills...fatigue, hair loss, inability to eat, constipation, and low hemoglobin....a suppressed immune system, you know, exactly what make my brain scream: Whaooo I really needed this! I feel so much better now! as I puke my brains out and find it hard to get the strength to get out of bed and get to the bathroom on time....
The payback you may ask? So far lowered CANCER MARKERS! For God's fkng sake!
My cancer progressed into my liver while under the best of care....need I explain more as to my lack of enthusiasm? And those dismal results were with approved drugs!!!
Cureious, I sure hope you're right...nothing would make me happier than to survive the trial and give everyone great news....but from the somber tones, the withdrawal of important, pivotal, intelligent information....the fact that I will be only the second person at MSK to join this trial, does NOT bode well...
But of course I could be completely wrong....which would be a first for me, so only time will tell....I truly hope to be completely off track on this one...
I will be positive and bless this effort and everyone's part! Meanwhile...God help us all...but there's no way in hell Im going to suffer for months on end...at the first sign of dangers to my health, I'm out of there...
Wait it gets better...When I asked if I would be able to take less pills in the case of severe sickness, they said that I should call the hospital, and they would call The Pfizer guy—try to reach him on the golf course, while dining at Morimoto, or while in bed with his wife—to ask him, what I should do...
now, I ask you folks....do you think I'm the kind of woman that has EVER waited for someone else to make an executive decision? Especially about my body? What the heck would he know what I'm experiencing from where he is? And why would he care about my wellbeing, which could undermine his priorities?
The Faslodex is to be added to part b of the trial...no mention of blocking CDK12 at this stage of the game....
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well, life is an adventure! your trial is also being offered at UCSF and MD Anderson, so there must be some hope somewhere in Pfizer about this- OTOH, they have more money than god to spend at the moment, based on the haul they are getting from Ibrance...
What I meant about CDK12 is that many of these drugs have cross-inhibition of other CDKs, and therefore the drug you will be taking may also be inhibiting CDK12. If they haven't tested for that specifically, then nobody knows, and certainly not anybody on the team doling it out, for sure, so I would not assume they know the drug is a bust, not nearly enough people have taken it.
Basically the bigger question with this or any drug, nowadays, is it doing anything to the tumor immunosuppresive environment? We know that Ibrance does help, but we havent heard anything from trials meant to determine if it allows immunotherapy to work better for MBC. Adding in yet another CDK, in a different formulation, what can this drug do to help that , more important, part of the equation?
Enjoy your week off!!!!
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also CDK2 inhibitors are reported to protect against the heart damage and hearing loss observed with doxycline and cisplatin, so that's a plus..
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Miao, maybe the personnel at the trial are that way because they are not supposed to be all happy and give patients false hope. They may be instructed to do that. And you have little Miss Sunshine here (Cure-ious) to boost your spirits.
During the trial, wouldn't you have support from the trial people for help 24/7? Even my MO's office has that. Even on a long holiday weekend. I'm glad you are not starting this weekend but still.
I follow this thread because I love your attitude toward big pharma and medicine in general. I lived in NYC for ten years. I miss the sass. Doesn't go over so well here.
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Miaomix thanks for your post - it all makes more sense to me now, where you are coming from and your experiences with your doctors. And the Pfizer person who is probably out golfing or getting laid, ugh!!! very scary!!!
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Jaycee...I have a very personal, respectful, and intimate relationship with everyone that takes care of me at the hospital. These are very generous, intelligent, and sensitive people that give me great attention when I'm there. I never have to wait, for example... because they know that greatly annoys me, I honestly left my previous hospital because of the long delays...and that was a walking distance from my home...now it takes an hour to get uptown....I live west on fifth near union square...as an ex New Yorker you understand the geography
I know that in their heart, they are doing their very best with what they have...so when the tone is different it is noticeable.
But like you said, this is probably routine and the nurses are new to me—I've never participated in a clinical trial before—but no promises were made regarding benefits...instead, posted on the agreement it clearly states to not expect any benefits from the medications, those would be reserved for future generations.
I'm sure once I get going and I really assess how much it affects my normal well-being, I'll hopefully be able to play ball like I'm supposed to...and deliver good tidings to our great community, especially our indomitable Cureious that will help me ride the waves, and make me appreciate, like she does, what the heck it’s going on....
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Husband....thank you for sharing that comprehensive list of complimentary medicines that have been so helpful to your wife. I have to still order some of the Japanese medicinal mushrooms, so far I’ve been making Chaga long extracted teas and Turkey tails pills. They are both excellent at lowering blood sugar levels, and in view of what I read in the McLelland book, blocking the glycemic pathway is very important. She mentions Metformin and Berberine a lot, which I use, but the effect of the mushrooms is astounding!
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Jaycee- Ha!!! I was wondering when someone would finally tire of my peppy attitude!!
Just happy to be here and feeling good, way beyond what I'd expected...
But it won't last if something big doesn't break soon & pull my fanny out of the fryer,
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Hi everyone, just want to let you know that you can get Safeguard from Amazon, which is fenben liquid. It's a 1000 ml bottle. I figured it out to a quarter tsp which is about 225 mg. Last I checked it was $137. I will contribute more after I start it. Idk why I keep putting it off. I'm on a break from chemo and taking nothing right now.
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Best of luck on the trial Miaomix! You’re doing good work for everyone in the community—on behalf of my family thank you!
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hi skyfly and thank you for your support...i wish you and your mom the best!
Lets keep hope alive, and NOT settle for the usual three month's extension over nothing...
HLB....perfect timing for trying this protocol...I'm off treatments too and I feel better than ever...a few acupuncture sessions so far have been amazing in restoring my strength and overall balance.
Maybe this is the reason why I find it so hard to accept future fatigue, nausea, a compromised immune system and an impaired or destroyed digestive system. In the real world, this scenario would make a great plot for a horror movie....would be the stuff of nightmares....definitely NOT associated with a healing modality.
How did we get so far from logic and reason??
Probably desperation....and lack of successful alternatives...but now that I see the light at the end of the tunnel....Reason and Hope have made a strong comeback...and I'm finding it really hard to dissociate and sleepwalk through this nightmare again.
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Snooky how are you girl? Thinking about you and your arm...has it healed properly? Are you Okay? Sending you good vibes....
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Cure-ious - Just wanted to say I think most of us that are interested in new developments/treatments etc owe what we know to you and your inquisitive nature! Please don't lose an inch of your curiosity! We're counting on you to decipher the jargon ... Hopefully we can reciprocate at times
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Mio? is that you? Frisky I like that handle. Thanks for asking about me. Chemo was Mon. and this steroid crash was a difficult one. About my arm, since I don't know what healing is suppose to be like well...……my entire forearm is red like a light sun burn and the skin feels tight.
So, I've been hibernating in my bed for last couple of days. I truly do not understand about the scans we take. Allow me to recap. My Nuc Bone scan on 5/3 concerned my ONC becaue of the amount of cancer at the T10. So apt with Radiology, on this past Tues. Three different radiologist looked at my scans for last 9 mos. AND their opinion was "little to no cancer in that area" the Nuc Bone scan was showing healing bone from a compression fracture. Conclusion lets get an MRI and settle this.
Well, imagine my surprise when I went I for results this past Thurs. The MRI showed cancer in the T10 and the Radiologist wants to do 10 sessions on me. There is danger of it eating right thru my spine.
Taxol while shrinking soft tissue is letting bone mets run amuck! The ONC is now talking about a port. which I'm starting to give serious consideration to . (Thx Jay)
But, I'm trying to remain positive, and believe and trust in Joe's protocol. Lost my mojo this week, but I'll find it.
Update I'm in week 3, this will be third day, of Joe's Protocol. Only doing it with Vit. E
Good vibes and best wishes to everyone on this thread! Hugs
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dear Snooky...I can see why you would want to chill after the emotional roller coaster ride you’ve been on. I sensed you had a lot on your mind..I’m sorry about the inconsistent reports. Unfortunately, it’s a common problem, and we are the ones that are left to wonder and worry about what any of this means. It rubs us of our trust in our doctors, their therapies, and the system in general.
The radiations will stop progression and reduce the cancer load and pains you might feel....it was helpful to me. So it might be exactly what you need in view of taxol lack of success in that area.
May this therapy put an end of your roller coaster ride, that unfortunately we all understand too well. May your arm heal quickly....and yes, at times such as this, Joe’s protocol keeps our hope alive.
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FenBen can be ordered at
I just order 4gram/3packs for 12.52 and then got a Memorial Day 12% off.
This place was recommended on Joe's FB
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Snooky, so if I'm thinking right, 1 packet would last for 4 days?
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Can I ask-- how long people do this protocol? Is there a point at which you stop or is it indefinite?
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Santa, it's all new, but the guy in the blog is doing it continuously. I guess it's your call!
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Lucia- Thanks but this site more than pays for the cost of admission (well, which is free anyway) with SO much info that is not available anywhere else!! Just in 2019 we learned about the immunotherapy trial-EP4 combo from kattysmith, the Super-Ibrance-CDK2 inhibitor Miao is going to be taking, the CAR-T trial from BlainJen, and how to handle the rash and blood sugar problems of PiqRay/Alpelisib from SusaninSF. And we're gearing up for our own clinical trial of dog dewormer (and probably will get more than the 20 or so people that make up most phase 1 trials). Ain't none of that info to be found anywhere else, even in the science literature. I love it here!!
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I just ordered from the website above www.bestvetcare.com. FYI-They ship from the UK!
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Santa...I can't wait to see what the pet scan will reveal, couple months from now...that's the only objective way of knowing how and if the therapy is working...a part from the unreliable cancer markers.
However even if there are no change, or negative changes I will continue to take the FZ but in different combinations, such as taking it everyday, or taking it on an empty stomach for maximum effect...
Also, I would add all the off-labels medications that block the various pathways simultaneously
I wonder why, our MOs don't constantly rotate the various treatments on a monthly basis. This would preclude the cancer cells from adapting, mutating and metastasizing, because they wouldn't know what pathway would be blocked next. In this way we would never run out of TXs options since we would be recycling them at infinatum...
What say yee.?
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yes Frisky. I was just asking that at the ibrance thread. And of course it was Cure-ious that pointed me in the direction of the website that mentions adaptive therapy. Developed by a radiologist. Didnt read too much yet, but what you're saying is what I'm asking. Damn. These drs can't even see what they are treating half the time. If you're stage 4 you would think they would be open to try more of these options be it therapy like you suggest or using older drugs off label or whatever the patient asks for. Never mind the double blind studies. . . Just feeling frustrated today. I'll blame all the rain.
GAILMARY
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gailmary....being a Copycat, I was inspired by your previous post and the solution offered by the McLelland survival story....
....i have so many unopened boxes of medications from past treatments, received right before a pet scan showed progression, that I might end up doing my own personal experiment for several months when and if my situation gets precarious.....
I would rather do it under medical supervision, but like you, I also fear that our MOs are just too conservative to think outside the box....
Right now, I just hope that Joe's protocol saves the day...but we also have the MacLelland modality we can use.
we must turn our focus on surviving this disease...unfortunately, if we blindly follow traditional therapies, we can only expect traditional outcomes
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Our MOs are not allowed to think outside the box, they are in risk to loose they're PhD
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Goldie, Yes they ship from UK. For free if you want them to.. But, I paid the 4.95 so the package could be traced. Normally, I wouldn't order from a company across the pond but this company was recommended on Joe's page. Sorry, I never answered your question, yes....each package is 4 doses.
Frisky, when I was first diagnosed in 7/17 after tests I was sent right to a surgeon. That woman, well, you had to be there. I left her office with my son and his wife never to go back.
Came home read everything about alternatives that I could find. My breast tumor did not grow a lot (like 1mm) for 7 months. Since my eating habits totally changed I had numerous benefits from my life style and lots of alternative treatments.
The problem, (I say that lovingly) was my three sons. They intervened and begged me to go traditional medicine. So here I am alive, but...…..well you know the rest. Plus, there's no way that I can know whether I could've kept the cancer at bay for any length of time. But my mental/emotional reactions to cancer was so different. I was in control of my body not my cancer.
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