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HER2-Positive Brain Mets Respond to Enhertu
HER2-Positive Brain Mets Respond to Enhertu September 12, 2014 The targeted therapy Enhertu (chemical name: fam-trastuzumab-deruxtecan-nxki) helped control areas of metastatic HER2-positive breast cancer in the brain, according to results from the DESTINY-Breast12 study presented on Sept. 13 at ESMO 2024. Read more…
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leptomeningeal metastasis
so I have been diagnosed with them (lesions in posterior cerebral fossa on cranial nerves and in spine). chemo changed for Enhertu trying to stave off a disease while the preparations for intratecal chemo via Omaya reservoir going. Looking back in the hindsight there were symptoms of it in August, just not visible on…
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patty
Does anyone have info on Patty? Haven't seen her here for awhile.
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Pik3ca E110del mutation? it's rare
anyone have a PIK3CA E110del mutation? I do. it's rare, like 1 in 4000 Pik3ca mutation is E110del. it kept me out of a clinical trial because I didn't have one of the top 10 mutations. arghghgh. we're going to try Piqray anyways. arghagrhgargharghghhgh. Same thing happened with my ESR1 mutation as well. I guess I'm…
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Peritonial carcinomatosis - help
Hello everyone! Today I learned from the CT examination that peritoneal carcinomatosis appeared. I am desperate because things were going well! I am waiting for encouragement and opinions from those with this type of breast cancer metastasis: peritoneal carcinomatosis. Has anyone tried HIPEC therapy or PIPEC therapy? I…
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Any stage IV surviving 5+ years ?
When you look up stats for stage IV they’re dismal, yet I continue to see lots of longer term survivors on this site. Some were given a year or two. Would love to hear how many are there and how life’s is for you. I’m coming up on three years and just failed with letrozole. MO says plenty options sti
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How do you lift your spirits, even briefly...
…when you receive troubling news about your tx, health, etc.? How do you comfort yourself and make yourself feel safe in spite of troubling labs, scans, etc.? I ask because it seems lately my check ups have been disappointing and although I try not to have any expectations about any of the tx I'm getting, I have to have…
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Moving on from Ibrance to Orserdu
After 7.5 years on Ibrance & Letrozole I had slight progression. A blood biopsy was ordered and I remained on I/L. I had developed great pain in my shoulder and this was found to be cancer. Blood biopsy reported ERS1 & PIK3CA mutations. I completed 5 rounds of radiotherapy to the shoulder and 2 days later on 29th of March…
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Mammogram if metastatic
Do you gals with metastatic disease still have annual mammograms? I can't understand why they would be necessary with ct scans every 3 to 6 months. Is the Dr just drumming up business for the hospital? What does your MO say? I haven't had one since 2017 when I thought I was all clear and 2 months later found cancer in my…
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Young with MBC
This is a thread for those 45 and under who have been diagnosed with metastatic breast cancer, and facing the unique challenges associated with receiving this diagnosis at a young age. Please feel free to discuss here, share your story, and support each other! --Your Mods
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High creatinine, high ketones?
I am not sure how common these side effects are, but I've been experiencing them so I thought I'd check in and see if there's anyone who has already experienced these and can maybe shed some light on what I might expect. My meds include kisqali and letrozole. Not sure what might be causing the issues. TMI time: I noticed…
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MSM (Methylsulfonylmethane) -Sulfur supplement
Is anyone else taking MSM? I started this week because I read that it can help with joint pain, inflammation, hair loss, nail damage and diverticulosis a new issue that has come up for me. I'm taking it in powder form, dissolved in a large glass of water. So far it is vile! I can taste it in my mouth all day. I'm just…
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Rectal issues
Well if you've opened this thread you either have them too, have nothing better to do, or maybe you're just curious. Amidst all the sadness on here lately and the sisters with serious issues i am hesitant to post this comparatively trivial complaint. But being as I am in bed on my iPad with a painful hemmoroid I have…
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Ischmetic stroke
Hi, I am on Palbociclib 125mg and Exemestane since last 5 years. I have mets in the bones which are under control. I also have X-Geva once in three months and have monthly shots of goserilin. I recently had Ischmetic stroke. All the cardiac diagnosis like echo, Holter test was ok. Also brain and neck angiography is also…
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Recent diagnosis
TNBC stage 4 Ductal metastatic 6.9 cm tumor in right armpit breast tissue, 3 cm on right breast, clavicle, possibly groin left side. Palliative taxol chemo & immunotherapy since the large one in my armpit is protruding out & would grow outside of my skin. 6 mo-1.5 yrs is what they gave me. Diagnosed 6/2024. Just finished…
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Not responding to Verzenio after some months: anyone switch to Kisquali? Help please
Hi all My tumor markers dropped for the first few months on Verzenio/Fulvestrant, and now are climbing again. Scans didn't show progress last month but I'm terrified. Did anyone have better response switching to Kisquali and if so, what was it and how were the side effects compared to Verzenio? Verzenio and I are getting…
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Has Anyone Had TEMPUS Blood Testing Done?
I’ve been stable on Xeloda since 2020. Recent ct/bone scans show a couple enlarged paratracheal (neck area) lymph nodes (everything else appears stable). Today I had a PET scan ordered by my onc to further investigate what might be going on. When I was at the onc last week, I also had blood drawn for TEMPUS xF testing. Has…
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Liver mets: resection, ablation, SBRT, Y-90, anything else?
I'm interested in who has had local treatment for liver mets and what was your experience and outcome. I've been talking about this with my onc, and he seems a little hesitant. I have my regular appt. for a 2-mth MRI of brain and followup with rad onc. I plan to ask him about the possibilities. I think that some of the…
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Our treatment histories
Hello, So far, I've been a silent member only, so this is my first post. I have been following many discussions regularly, and found this forum an incredibly helpful and encouraging place. I was wondering if we could have a thread to collect our treatment histories? Which drugs we've been on, how long we've been on each,…
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Tamoxifen and breast tenderness
I finished chemo (12 cycles) May 30th. IDC, Mets to liver, ER and HER2 positive. Still on herceptin and perjeta. I’ve been on tamoxifen for 3 weeks and I’ve had breast tenderness since I started. It comes and goes. Anyone else?
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Vegetarian Diet Offers Physical, Mental Benefits for Women With Metastatic Breast Cancer
Vegetarian Diet Offers Physical, Mental Benefits for Women With Metastatic Breast Cancer Jul 24, 2024 If you have metastatic breast cancer, a whole-food, plant-based diet may help you think and feel better. Read more…
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Which Type of Radiation Is Best for Painful Spots of Cancer in Spine?
Which Type of Radiation Is Best for Painful Spots of Cancer in Spine? Jul 11, 2024 Stereotactic body radiation seems best for easing pain caused by spots of metastatic cancer in the spine. Read more…
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Exercise Boosts Sexual Health in Women With Metastatic Breast Cancer
Exercise Boosts Sexual Health in Women With Metastatic Breast Cancer Jul 9, 2024 If you have metastatic disease and want better sex, exercise can help. Read more…
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Enhertu Beats Chemotherapy for HER2-Low and -Ultralow Metastatic Breast Cancer
Enhertu Beats Chemotherapy for HER2-Low and -Ultralow Metastatic Breast Cancer Jun 17, 2024 Enhertu seems better than chemotherapy for metastatic breast cancers with even the lowest detectable levels of HER2. Read more…
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Multiple Organ Mets and on Kisqali/Ribociclib (3+yrs)
I always hear amazing stories from those with dx’d with bone mets de novo on this drug. Curious to hear from those with multiple organ mets or were dx’d secondary who have done well long term on the Kisqali/Ribociclib combo. Where were your mets, and how long have you been on this treatment?
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Progression question
I have severe scanxiety right now…had scans yesterday (nuclear bone and CT). Previous insurance wouldn't pay for a PET, but since I have changed insurances recently I am going to pursue that again for the next scan. I'm told by my MO that I will have to have scans every three months. My fear, of course, is that these scans…
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Truqap experience
stage 4 Mets to lung, liver, bones and lymph On the sixth week of truqap, handling it pretty well. Some diarrhea that is unpredictable so I always have Imodium on hand. Sometimes I get nauseous and my taste is off. My concern is for the blood sugar levels. Trying to keep my diet during the four days which is no sugars but…
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Enhertu Beats Chemotherapy for HER2-Low and -Ultralow Metastatic Breast Cancer
Enhertu Beats Chemotherapy for HER2-Low and -Ultralow Metastatic Breast Cancer Jun 17, 2024 Enhertu offers better survival than chemotherapy for pre-treated, metastatic, HER2-low or -ultralow breast cancer. Read more…
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Faslodex
Just wondering if anyone has experienced this. I have been on faslodex (and Ibrance) for 3 and a half years. I am so fortunate that his combo is still working and don't want to change it. I have always had a couple of side effect days after shots but bearable. Though recently my side effects seem worse. Anyone experience…
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Trodelvy Now Approved for Hormone Receptor-Positive MBC
Trodelvy Approved for Metastatic, Hormone Receptor-Positive Breast Cancer Feb 3, 2023 Trodelvy is now approved to treat metastatic, hormone receptor-positive breast cancer, rather than only triple-negative disease. Read more...